Skip to main content

Rheumatoid Arthritis

  • Chapter
  • First Online:
Rheumatology for Primary Care Providers

Abstract

Rheumatoid arthritis (RA) is a systemic chronic autoinflammatory disease that eventually leads to a progressive destruction of cartilage and bone tissue of the joints. Early diagnosis of RA based on the clinical presentation and laboratory findings is of utmost importance to initiate adequate therapy. Therapeutic options have dramatically improved during the last 20 years due to the rise of biological and synthetic targeted therapies. Nevertheless, several unmet needs still exist that require further insights from basic research to uncover the cause(s) of RA.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 129.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

References

  1. Smolen JS, et al. Rheumatoid arthritis. Nat Rev Dis Primers. 2018;4:1–23.

    Article  Google Scholar 

  2. Nell V, et al. Autoantibody profiling as early diagnostic and prognostic tool for rheumatoid arthritis. Ann Rheum Dis. 2005;64:1731–6.

    Article  CAS  Google Scholar 

  3. Scott DL, Wolfe F, Huizinga TW. Rheumatoid arthritis. Lancet. 2010;376:1094–108.

    Article  Google Scholar 

  4. Aletaha D, et al. 2010 rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Ann Rheum Dis. 2010;69:1580–8.

    Article  Google Scholar 

  5. Quinn M, Green M, Conaghan P, Emery P. How do you diagnose rheumatoid arthritis early? Best Pract Res Clin Rheumatol. 2001;15:49–66.

    Article  CAS  Google Scholar 

  6. Young A, Koduri G. Extra-articular manifestations and complications of rheumatoid arthritis. Best Pract Res Clin Rheumatol. 2007;21:907–27.

    Article  Google Scholar 

  7. Kvien TK, et al. Considerations for improving quality of care of patients with rheumatoid arthritis and associated comorbidities. RMD Open. 2020;6:e001211.

    Article  Google Scholar 

  8. Colebatch AN, et al. EULAR recommendations for the use of imaging of the joints in the clinical management of rheumatoid arthritis. Ann Rheum Dis. 2013;72(6):804–14.

    Article  Google Scholar 

  9. Smolen JS, et al. EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2019 update. Ann Rheum Dis. 2020;79(6):685–99.

    Article  CAS  Google Scholar 

  10. Shea B, et al. Folic acid and folinic acid for reducing side effects in patients receiving methotrexate for rheumatoid arthritis. Cochrane Database Syst Rev. 2013;13(5):CD000951.

    Google Scholar 

  11. Doevendans E, Schellekens H. Immunogenicity of innovative and biosimilar monoclonal antibodies. Antibodies. 2019;8:21–10.

    Article  CAS  Google Scholar 

  12. Mertens M, Singh JA. Anakinra for rheumatoid arthritis. Cochrane Database Syst Rev. 2009;41:CD005121.

    Google Scholar 

  13. Schwartz DM, et al. JAK inhibition as a therapeutic strategy for immune and inflammatory diseases. Nat Rev Drug Discov. 2017;16:843–62.

    Article  CAS  Google Scholar 

  14. Vlieland TPMV, Pattison D. Non-drug therapies in early rheumatoid arthritis. Best Pract Res Clin Rheumatol. 2009;23:103–16.

    Article  Google Scholar 

  15. Hagen K, Byfuglien M, Falzon L, Olsen S, Smedslund G. Dietary interventions for rheumatoid arthritis. Cochrane Database Syst Rev. 2009:CD006400.

    Google Scholar 

  16. Burmester G-R, et al. Evolving the comprehensive management of rheumatoid arthritis: identification of unmet needs and development of practical and educational tools. Clin Exp Rheumatol. 2020;38(6):1056–67.

    PubMed  Google Scholar 

  17. Wong PKK, Hanrahan P. Management of vaccination in rheumatic disease. Best Pract Res Clin Rheumatol. 2019;32:720–34.

    Article  Google Scholar 

  18. Smeele HTW, Dolhain RJEM. Current perspectives on fertility, pregnancy and childbirth in patients with Rheumatoid Arthritis. Semin Arthritis Rheu. 2019;49:S32–5.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Clemens Scheinecker .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2022 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Scheinecker, C., Aletaha, D. (2022). Rheumatoid Arthritis. In: Ali, Y. (eds) Rheumatology for Primary Care Providers. Springer, Cham. https://doi.org/10.1007/978-3-030-80699-6_3

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-80699-6_3

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-80698-9

  • Online ISBN: 978-3-030-80699-6

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics