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Adipokines and Thyroid Malignancies

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Thyroid, Obesity and Metabolism

Abstract

Thyroid cancer (TC) is the most frequent endocrine tumor, and its incidence is increasing worldwide. Differentiated thyroid cancer (DTC) prognosis is excellent in the majority of cases, with a 10-year overall relative survival rates of about 90% for DTCs, but a few thyroid tumors are aggressive and refractory to conventional therapies.

There are several known risk factors for TC as previous exposure to ionizing radiation, but other unknown risk factors are still being investigated.

The increased incidence rates of TCs recorded over the last decades appear in parallel with the increased incidence in obesity and metabolic disorders, since interesting studies suggested an epidemiological link between TC and metabolic imbalance.

There are some epidemiological data to support that obesity is independently associated with an increased incidence of various solid tumors, including TC. Some hypotheses have been formulated to suggest potential mechanisms, implicating factors such as inflammation and adipokines, obesity, hyperinsulinemia and insulin resistance, but data are still scanty and controversial.

As currently metabolic disorders are becoming more prevalent in daily clinical activity, it is interesting to expand these studies to confirm the potential correlation between metabolic disorders and thyroid carcinoma.

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Authors and Affiliations

  1. Division of Endocrine and Metabolic Diseases, Istituto Auxologico Italiano IRCCS, Milan, Italy

    Carla Colombo & Laura Fugazzola

  2. Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy

    Carla Colombo & Laura Fugazzola

Authors
  1. Carla Colombo
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  2. Laura Fugazzola
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Correspondence to Laura Fugazzola .

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Editors and Affiliations

  1. Department of Endocrinology, Nutrition and Metabolic Diseases, IRCCS MultiMedica, Sesto San Giovanni and Ospedale San Giuseppe, Milano, Italy

    Livio Luzi

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Colombo, C., Fugazzola, L. (2021). Adipokines and Thyroid Malignancies. In: Luzi, L. (eds) Thyroid, Obesity and Metabolism. Springer, Cham. https://doi.org/10.1007/978-3-030-80267-7_15

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  • DOI: https://doi.org/10.1007/978-3-030-80267-7_15

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-80266-0

  • Online ISBN: 978-3-030-80267-7

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