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Polymer-Based Swimming Nanorobots Driven by Chemical Fuels

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Field-Driven Micro and Nanorobots for Biology and Medicine

Abstract

Field-driven biomedical micro-/nanorobots have attracted significant attention over the past decades because of their potential promises to be controlled toward hard-to-reach tissues for various biological and medical usages including active targeted drug/gene delivery, detoxification, and nanosurgery. Learning from biological molecular motors such as kinesin, which exert the autonomous motion though spontaneous hydrolysis of adenosine triphosphate into mechanic movement. Substantial efforts toward the development of chemically powered swimming micro-/nanorobots have recently demonstrated the capability of converting chemical energy into mechanical motion based on a fuel solution. In spite of the great promise, the major materials of the past chemical swimming micro-/nanorobots are primarily based on metals or metallic oxide with poor biocompatibility and biodegradability. With the envision of Richard Feynman, who imagined the fabrication of micro- and nanoscale machines by rearranging atoms and molecules, considerable efforts were devoted toward the chemical micro-/nanorobotics based on polymers with bottom-up techniques such as layer-by-layer molecular assembly and supramolecular assembly. In this chapter, we summarize the recent advances on investigating the fabrication of polymer-based micro-/nanorobots using bottom-up approaches and various aspects of their chemically powered propulsion including the propulsion mechanism, movement guidance, and chemotaxis. We also highlight the emerging technological approaches to enhance the navigation performances of micro-/nanorobots. The recent demonstrations of autonomous self-seeking motion and biomedical applications of such micro-/nanorobots are introduced. We conceive that perpetual polymer and fabrication innovations with interdisciplinary efforts can drive us closer to the fantasy of “swallowing surgeons.”

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References

  1. (a) Ozin, G. A., Manners, I., Fournier-Bidoz, S., & Arsenault, A. (2005). Advanced Materials, 17, 3011–3018; (b) Wang, J. (2013). Nanotechnology; (c) Sitti, M. J. N. R. M. (2018). Nature Reviews Materials, 3, 74–75; (d) Gao, C., Wang, Y., Ye, Z., Lin, Z., Ma, X., & He, Q. (2020). Advanced Materials, e2000512.

    Google Scholar 

  2. Purcell, E. M. (1977). American Journal of Physics, 45, 3–11.

    Article  Google Scholar 

  3. He, Q., Duan, L., Qi, W., Wang, K., Cui, Y., Yan, X., & Li, J. (2008). Advanced Materials, 20, 2933–2937.

    Article  Google Scholar 

  4. Wu, Z., Lin, X., Si, T., & He, Q. (2016). Small, 12, 3080–3093.

    Article  Google Scholar 

  5. Lin, X., Wu, Z., Wu, Y., Xuan, M., & He, Q. (2016). Advanced Materials, 28, 1060–1072.

    Article  Google Scholar 

  6. Ariga, K., Ji, Q., Hill, J. P., Bando, Y., & Aono, M. (2012). NPG Asia Materials, 4, e17.

    Article  Google Scholar 

  7. Ai, S., Lu, G., He, Q., & Li, J. (2003). Journal of the American Chemical Society, 125, 11140.

    Article  Google Scholar 

  8. Zhang, X., Chen, H., & Zhang, H. (2007). Chemical Communications, 14, 1395–1405.

    Article  Google Scholar 

  9. Wu, Y., Wu, Z., Lin, X., He, Q., & Li, J. (2012). ACS Nano, 6, 10910–10916.

    Article  Google Scholar 

  10. Wu, Y., Si, T., Lin, X., & He, Q. (2014). Chemical Communications, 51, 511–514.

    Article  Google Scholar 

  11. Del Mercato, L., Carraro, M., Zizzari, A., Bianco, M., Miglietta, R., Arima, V., Viola, I., Nobile, C., Sorarù, A., & Vilona, D. (2014). Chemistry – A European Journal, 20, 10910–10914.

    Article  Google Scholar 

  12. Wu, Z., Wu, Y., He, W., Lin, X., Sun, J., & He, Q. (2013). Angewandte Chemie, International Edition, 52, 7000–7003.

    Article  Google Scholar 

  13. Li, J., Huang, G., Ye, M., Li, M., Liu, R., & Mei, Y. (2011). Nanoscale, 3, 5083–5089.

    Article  Google Scholar 

  14. Wilson, D. A., Nolte, R. J. M., & van Hest, J. C. M. (2012). Nature Chemistry, 4, 268–274.

    Article  Google Scholar 

  15. Wu, Z., Li, J., Estebanfernandez De Avila, B., Li, T., Gao, W., He, Q., Zhang, L., & Wang, J. (2015). Advanced Functional Materials, 25, 7497–7501.

    Article  Google Scholar 

  16. Gao, C., Lin, Z., Jurado-Sánchez, B., Lin, X., Wu, Z., & He, Q. (2016). Small, 12, 4056–4062.

    Article  Google Scholar 

  17. Gao, C., Lin, Z., Wu, Z., Lin, X., & He, Q. (2016). ACS Applied Materials & Interfaces, 8, 34252–34260.

    Article  Google Scholar 

  18. Chen, C., Chang, X., Angsantikul, P., Li, J., Estebanfernandez De Avila, B., Karshalev, E., Liu, W., Mou, F., He, S., Castillo, R., Liang, Y., Guan, J., Zhang, L., & Wang, J. (2018). Advanced Biosystems, 2, 1700160.

    Article  Google Scholar 

  19. Deng, Z., Mou, F., Tang, S., Xu, L., Luo, M., & Guan, J. (2018). Applied Materials Today, 13, 45–53.

    Article  Google Scholar 

  20. Kline, T., Paxton, W., Mallouk, T., & Sen, A. (2004). Angewandte Chemie, International Edition, 44, 744–746.

    Article  Google Scholar 

  21. Burdick, J., Laocharoensuk, R., Wheat, P. M., Posner, J. D., Wang, J., & Am, J. (2008). Chemical Society, 130, 8164–8165.

    Article  Google Scholar 

  22. Tu, Y., Peng, F., Sui, X., Men, Y., White, P. B., van Hest, J. C. M., & Wilson, D. A. (2016). Nature Chemistry, 9, 480–486.

    Article  Google Scholar 

  23. Wu, Z., Lin, X., Wu, Y., Si, T., Sun, J., & He, Q. (2014). ACS Nano, 8, 6097–6105.

    Article  Google Scholar 

  24. Balasubramanian, S., Kagan, D., Manesh, K. M., Calvomarzal, P., Flechsig, G., & Wang, J. (2009). Small, 5, 1569–1574.

    Article  Google Scholar 

  25. Ionov, L. (2010). Journal of Materials Chemistry, 20, 3382–3390.

    Article  Google Scholar 

  26. Magdanz, V., Stoychev, G., Ionov, L., Sanchez, S., & Schmidt, O. (2014). Angewandte Chemie, International Edition, 53, 2673–2677.

    Article  Google Scholar 

  27. Gennes, P. G. D. (2010). Angewandte Chemie, International Edition, 104, 856–859.

    Article  Google Scholar 

  28. Calvomarzal, P., Manesh, K. M., Kagan, D., Balasubramanian, S., Cardona, M., Flechsig, G., Posner, J. D., & Wang, J. (2009). Chemical Communications, 4509–4511.

    Google Scholar 

  29. Qin, L., Banholzer, M. J., Xu, X., Huang, L., & Mirkin, C. A. (2007). Journal of the American Chemical Society, 129, 14870–14871.

    Article  Google Scholar 

  30. Ji, Y., Lin, X., Wu, Z., Wu, Y., Gao, W., & He, Q. (2019). Angewandte Chemie, International Edition, 58, 12200–12205.

    Article  Google Scholar 

  31. Hong, Y., Blackman, N. M. K., Kopp, N. D., Sen, A., & Velegol, D. (2007). Physical Review Letters, 99, 178103.

    Article  Google Scholar 

  32. Baraban, L., Harazim, S., Sanchez, S., & Schmidt, O. G. (2013). Angewandte Chemie, International Edition, 52, 5552–5556.

    Article  Google Scholar 

  33. Peng, F., Tu, Y., van Hest, J. C. M., & Wilson, D. A. (2015). Angewandte Chemie, International Edition, 54, 11662–11665.

    Article  Google Scholar 

  34. Shao, J., Xuan, M., Dai, L., Si, T., Li, J., & He, Q. (2015). Angewandte Chemie, International Edition, 54, 12782–12787.

    Article  Google Scholar 

  35. Ji, Y., Lin, X., Wang, D., Zhou, C., Wu, Y., & He, Q. (2019). Chemistry, an Asian Journal, 14, 2450–2455.

    Article  Google Scholar 

  36. Ji, Y., Lin, X., Zhang, H., Wu, Y., Li, J., & He, Q. (2019). Angewandte Chemie, International Edition, 58, 4184–4188.

    Article  Google Scholar 

  37. Tang, S., Zhang, F., Gong, H., Wei, F., Zhuang, J., Karshalev, E., Ávila, B. E. F., Huang, C., Zhou, Z., Li, Z., Yin, L., Dong, H., Fang, R. H., Zhang, X., Zhang, L., & Wang, J. (2020). Science Robotics, 5, eaba6137.

    Article  Google Scholar 

  38. Karshalev, E., Esteban-Fernández de Ávila, B., Beltrán-Gastélum, M., Angsantikul, P., Tang, S., Mundaca-Uribe, R., Zhang, F., Zhao, J., Zhang, L., & Wang, J. (2018). ACS Nano, 12, 8397–8405.

    Article  Google Scholar 

  39. Li, J., Esteban-Fernández de Ávila, B., Gao, W., Zhang, L., & Wang, J. (2017). Science Robotics, 2, eaam6431.

    Article  Google Scholar 

  40. Xu, Z., Chen, M., Lee, H., Feng, S., & Yeon, J. (2019). ACS Applied Materials & Interfaces, 11, 15727–15732.

    Article  Google Scholar 

  41. Vilela, D., Cossío, U., Parmar, J., Gómez-Vallejo, V., Martínez, A. M., Llop, J., & Sanchez, S. (2018). ACS Nano, 12, 1220–1227.

    Article  Google Scholar 

  42. Yu, J., Jin, D., Chan, K. F., Wang, Q., & Zhang, L. (2019). Nature Communications, 10, 5631.

    Article  Google Scholar 

  43. Wu, Z., Li, L., Yang, Y., Hu, P., Li, Y., Yang, S.-Y., Wang, L. V., & Gao, W. (2019). Science Robotics, 4, eaax0613.

    Article  Google Scholar 

  44. Wan, M., Chen, H., Wang, Q., Niu, Q., Xu, P., Yu, Y., Zhu, T., Mao, C., & Shen, J. (2019). Nature Communications, 10, 966.

    Article  Google Scholar 

  45. Baylis, J. R., Yeon, J. H., Thomson, M. H., Kazerooni, A., Wang, X., John, A. E. S., Lim, E. B., Chien, D., Lee, A., Zhang, J. Q., Piret, J. M., Machan, L. S., Burke, T. F., White, N. J., & Kastrup, C. J. (2015). Science Advances, 1, e1500379.

    Article  Google Scholar 

  46. Gao, W., Dong, R., Thamphiwatana, S., Li, J., & Wang, J. (2015). ACS Nano, 9, 117–123.

    Article  Google Scholar 

  47. de Avila, B. E., Angsantikul, P., Li, J., Lopezramirez, M. A., Ramirezherrera, D. E., Thamphiwatana, S., Chen, C., Delezuk, J., Samakapiruk, R., Ramez, V., Obonyo, M., Zhang, L., & Wang, J.(2017). Nature Communications, 8, 272.

    Article  Google Scholar 

  48. Li, J., Thamphiwatana, S., Liu, W., Estebanfernandez De Avila, B., Angsantikul, P., Sandraz, E., Wang, J., Xu, T., Soto, F., Ramez, V., Wang, X., Gao, W., Zhang, L., & Wang, J. (2016). ACS Nano, 10, 9536–9542.

    Article  Google Scholar 

  49. Li, J., Angsantikul, P., Liu, W., De Avila, B. E., Thamphiwatana, S., Xu, M., Sandraz, E., Wang, X., Delezuk, J., & Gao, W. (2017). Angewandte Chemie, International Edition, 56, 2156–2161.

    Article  Google Scholar 

  50. Wei, X., Beltrán-Gastélum, M., Karshalev, E., Esteban-Fernández de Ávila, B., Zhou, J., Ran, D., Angsantikul, P., Fang, R. H., Wang, J., & Zhang, L. (2019). Nano Letters, 19, 4760–4769.

    Article  Google Scholar 

  51. He, W., Frueh, J., Hu, N., Liu, L., Gai, M., & He, Q. (2016). Advancement of Science, 3, 1600206.

    Google Scholar 

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Authors and Affiliations

  1. Key Laboratory of Micro-systems and Micro-structures Manufacturing (Ministry of Education), Harbin Institute of Technology, Harbin, China

    Zhiguang Wu, Tingxin Yang & Qiang He

Authors
  1. Zhiguang Wu
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  2. Tingxin Yang
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  3. Qiang He
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Corresponding author

Correspondence to Qiang He .

Editor information

Editors and Affiliations

  1. Robotics Institute, University of Toronto, Toronto, ON, Canada

    Yu Sun

  2. Program in Developmental and Stem Cell Biology, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada

    Xian Wang

  3. Shenzhen Institute of Artificial Intelligence and Robotics for Society, The Chinese University of Hong Kong, Shenzhen, Shenzhen, Guangdong, China

    Jiangfan Yu

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Wu, Z., Yang, T., He, Q. (2022). Polymer-Based Swimming Nanorobots Driven by Chemical Fuels. In: Sun, Y., Wang, X., Yu, J. (eds) Field-Driven Micro and Nanorobots for Biology and Medicine. Springer, Cham. https://doi.org/10.1007/978-3-030-80197-7_15

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  • DOI: https://doi.org/10.1007/978-3-030-80197-7_15

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  • Publisher Name: Springer, Cham

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  • Online ISBN: 978-3-030-80197-7

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