Skip to main content

Towards the Localisation of Lesions in Diabetic Retinopathy

  • Conference paper
  • First Online:
Intelligent Computing

Part of the book series: Lecture Notes in Networks and Systems ((LNNS,volume 285))

Abstract

Convolutional Neural Networks (CNNs) have successfully been used to classify diabetic retinopathy (DR) fundus images in recent times. However, deeper representations in CNNs may capture higher-level semantics at the expense of spatial resolution. To make predictions usable for ophthalmologists, we use a post-attention technique called Gradient-weighted Class Activation Mapping (Grad-CAM) on the penultimate layer of deep learning models to produce coarse localisation maps on DR fundus images. This is to help identify discriminative regions in the images, consequently providing evidence for ophthalmologists to make a diagnosis and potentially save lives by early diagnosis. Specifically, this study uses pre-trained weights from four state-of-the-art deep learning models to produce and compare localisation maps of DR fundus images. The models used include VGG16, ResNet50, InceptionV3, and InceptionResNetV2. We find that InceptionV3 achieves the best performance with a test classification accuracy of 96.07%, and localise lesions better and faster than the other models.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 259.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 329.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Notes

  1. 1.

    https://asiateleophth.org/.

References

  1. American Academy of Ophthalmology: International Clinical Diabetic Retinopathy Disease Severity Scale Detailed Table (2002)

    Google Scholar 

  2. Beede, E., et al.: A human-centered evaluation of a deep learning system deployed in clinics for the detection of diabetic retinopathy. In: Proceedings of the 2020 CHI Conference on Human Factors in Computing Systems, pp. 1–12 (2020)

    Google Scholar 

  3. Buda, M., Maki, A., Mazurowski, M.A.: A systematic study of the class imbalance problem in convolutional neural networks. Neural Netw. 106, 249–259 (2018)

    Article  Google Scholar 

  4. Gondal, W.M., Köhler, J.M., Grzeszick, R., Fink, G.A., Hirsch, M.: Weakly-supervised localization of diabetic retinopathy lesions in retinal fundus images. In: 2017 IEEE International Conference on Image Processing (ICIP), pp. 2069–2073 (2017)

    Google Scholar 

  5. Gulshan, V., et al.: Development and validation of a deep learning algorithm for detection of diabetic retinopathy in retinal fundus photographs. J. Am. Med. Assoc. (JAMA) 316(22), 2402–2410 (2016)

    Article  Google Scholar 

  6. He, K., Zhang, X., Ren, S., Sun, J.: Deep residual learning for image recognition. In: Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, pp. 770–778 (2016)

    Google Scholar 

  7. Johnson, J.M., Khoshgoftaar, T.M.: Survey on deep learning with class imbalance. J. Big Data 6(1), 27 (2019)

    Article  Google Scholar 

  8. Raghu, M., Zhang, C., Kleinberg, J., Bengio, S.: Transfusion: understanding transfer learning for medical imaging. In: Advances in Neural Information Processing Systems, pp. 3347–3357 (2019)

    Google Scholar 

  9. Ramachandran, P., Parmar, N., Vaswani, A., Bello, I., Levskaya, A. Shlens, J.: Stand-alone self-attention in vision models. arXiv preprint arXiv:1906.05909 (2019)

  10. Sahu, S., Singh, A.K., Ghrera, S.P., Elhoseny, M.: An approach for de-noising and contrast enhancement of retinal fundus image using CLAHE. Opt. Laser Technol. 110, 87–98 (2019)

    Article  Google Scholar 

  11. Selvaraju, R.R., Cogswell, M., Das, A., Vedantam, R., Parikh, D., Batra, D.: Grad-CAM: visual explanations from deep networks via gradient-based localization. In: Proceedings of the IEEE International Conference on Computer Vision, pp. 618–626 (2017)

    Google Scholar 

  12. Simonyan, K., Zisserman, A.: Very deep convolutional networks for large-scale image recognition. arXiv preprint arXiv:1409.1556 (2014)

  13. Szegedy, C., et al.: Going deeper with convolutions. In: Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, pp. 1–9 (2015)

    Google Scholar 

  14. Szegedy, C., Ioffe, S., Vanhoucke, V., Alemi, A.: Inception-v4, inception-resnet and the impact of residual connections on learning. arXiv preprint arXiv:1602.07261 (2016)

  15. Tan, C., Sun, F., Kong, T., Zhang, W., Yang, C., Liu, C.: A survey on deep transfer learning. In: Kurková, V., Manolopoulos, Y., Hammer, B., Iliadis, L., Maglogiannis, I. (eds.) International Conference on Artificial Neural Networks. ICANN 2018. Lecture Notes in Computer Science, vol. 11141, pp. 270–279. Springer, Cham (2018). https://doi.org/10.1007/978-3-030-01424-7_27

    Chapter  Google Scholar 

  16. Zhou, B., Khosla, A., Lapedriza, A., Oliva, A., Torralba, A.: Learning deep features for discriminative localization. In: Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, pp. 2921–2929 (2016)

    Google Scholar 

  17. Zuiderveld, K.: Contrast limited adaptive histogram equalization. In: Heckbert, P.S. (ed.) Graphics Gems, pp. 474–485. Academic Press, Boston (1994)

    Chapter  Google Scholar 

Download references

Acknowledgement

We would like to thank the German Academic Exchange Service (DAAD) for kindly offering financial support for this research. Also, we thank the Centre for High Performance Computing (CHPC) for providing us with computing resource for this research.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Samuel Ofosu Mensah .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2021 The Author(s), under exclusive license to Springer Nature Switzerland AG

About this paper

Check for updates. Verify currency and authenticity via CrossMark

Cite this paper

Mensah, S.O., Bah, B., Brink, W. (2021). Towards the Localisation of Lesions in Diabetic Retinopathy. In: Arai, K. (eds) Intelligent Computing. Lecture Notes in Networks and Systems, vol 285. Springer, Cham. https://doi.org/10.1007/978-3-030-80129-8_8

Download citation

Publish with us

Policies and ethics