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Circadian Regulation of Autophagy in the Heart Via the mTOR Pathway

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Biochemistry of Apoptosis and Autophagy

Part of the book series: Advances in Biochemistry in Health and Disease ((ABHD,volume 18))

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Abstract

Disruption of the normal circadian clock has been associated with greater incidence of cardiovascular disease in shift workers. While the underlying mechanisms for this phenomenon are poorly understood, recent evidence from our laboratory has identified a novel signalling axis that functionally connects the mechanistic target of rapamycin (mTOR) to circadian biology in cardiac myocytes. The mTOR pathway regulates several processes such as cell growth, metabolism, and homeostasis throughout the body. mTOR has been linked to the cardiovascular systems through its regulation of both physiological and pathological processes, making it a desirable suspect for the investigating of its role in cardiovascular disease emanating from circadian dysfunction. Herein, we review the relevant literature highlighting the interworking of circadian interaction with metabolism including nutrient stress and autophagy within the cardiovascular system. We hope to use this information to spark interest in the potential for circadian intervened therapies designed for improving cardiovascular metabolism.

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Acknowledgements

This work was supported by a Foundation grant to L.A.K from the Canadian Institute for Health Research (CIHR) and Heart and Stroke Foundation of Canada, L.A.K. holds a Canada Research Chair in Molecular Cardiology. I.R.N received CIHR fellowship, M.L. Holds a University of Manitoba Graduate Studentship Award.

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  1. Department of Physiology and Pathophysiology, The Institute of Cardiovascular Sciences, St. Boniface Hospital Albrechtsen Research Centre, Winnipeg, MB, R2H2A6, Canada

    Matthew Love, Inna Rabinovich-Nikitin & Lorrie A. Kirshenbaum

  2. Department of Pharmacology and Therapeutics, Rady College of Medicine, Max Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, R2H2A6, Canada

    Lorrie A. Kirshenbaum

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    Lorrie A. Kirshenbaum

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Love, M., Rabinovich-Nikitin, I., Kirshenbaum, L.A. (2022). Circadian Regulation of Autophagy in the Heart Via the mTOR Pathway. In: Kirshenbaum, L.A. (eds) Biochemistry of Apoptosis and Autophagy. Advances in Biochemistry in Health and Disease, vol 18. Springer, Cham. https://doi.org/10.1007/978-3-030-78799-8_9

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