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Caspase Signaling Pathways as Convenors of Stress Adaptation

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Biochemistry of Apoptosis and Autophagy

Part of the book series: Advances in Biochemistry in Health and Disease ((ABHD,volume 18))

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Abstract

Caspase proteins are a group of proteases that manage intermediate and late stages of programmed cell death/apoptosis. Despite the core cell death function inherent to caspases, these proteins also maintain distinct nonapoptotic functions across most metazoan organisms. Here, we review the role of caspases in cell differentiation and stress adaptation, and the evolution of nonapoptotic activity of these proteases and related factors. We also discuss how caspases integrate other cell death signaling pathways to manage and guide stress response in the mammalian heart, independent of cell death.

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Authors and Affiliations

  1. Ottawa Hospital Research Institute, Sprott Centre for Stem Cell Research, Regenerative Medicine Program, Ottawa Hospital, Ottawa, ON, K18L6, Canada

    Charis Putinski & Lynn A. Megeney

  2. Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, K18M5, Canada

    Charis Putinski & Lynn A. Megeney

  3. Department of Medicine, University of Ottawa, Ottawa, ON, K18M5, Canada

    Lynn A. Megeney

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  1. Charis Putinski
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  2. Lynn A. Megeney
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Correspondence to Lynn A. Megeney .

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Editors and Affiliations

  1. University of Manitoba, Winnipeg, MB, Canada

    Lorrie A. Kirshenbaum

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Putinski, C., Megeney, L.A. (2022). Caspase Signaling Pathways as Convenors of Stress Adaptation. In: Kirshenbaum, L.A. (eds) Biochemistry of Apoptosis and Autophagy. Advances in Biochemistry in Health and Disease, vol 18. Springer, Cham. https://doi.org/10.1007/978-3-030-78799-8_5

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