Abstract
In humans, there is a well-established relationship between atrial fibrillation (AF), blood flow abnormalities and thrombus formation, even if there is no clear consensus on the role of left atrial appendage (LAA) morphologies. Cats can also suffer heart diseases, often leading to an enlargement of the left atrium that promotes stagnant blood flow, activating the clotting process and promoting feline aortic thromboembolism. The majority of pathological feline hearts have echocardiographic evidence of abnormal left ventricular filling, usually assessed with 2D and Doppler echocardiography and standard imaging tools. Actually, veterinary professionals have limited access to advanced computational techniques that would enable a better understanding of feline heart pathologies with improved morphological and haemodynamic descriptors. In this work, we applied state-of-the-art image processing and computational fluid simulations based on micro-computed tomography images acquired in 24 cases, including normal cats and cats with varying severity of cardiomyopathy. The main goal of the study was to identify differences in the LA/LAA morphologies and blood flow patterns in the analysed cohorts with respect to thrombus formation and cardiac pathology. The obtained results show significant differences between normal and pathological feline hearts, as well as in thrombus vs non-thrombus cases and asymptomatic vs symptomatic cases, while it was not possible to discern in congestive heart failure with thrombus and from non-thrombus cases. Additionally, in-silico fluid simulations demonstrated lower LAA blood flow velocities and higher thrombotic risk in the thrombus cases.
Keywords
- Feline hearts
- Thrombus formation
- Congestive heart failure
- Left atrial appendage
- Computational fluid dynamics
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Note that two cases had both congestive heart failure and thrombus.
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References
Kiatsilapanan, A., et al.: Assessment of left atrial function in feline hypertrophic cardiomyopathy by using two-dimensional speckle tracking echocardiography. BMC Vet. Res. 3, 1–10 (2020)
Schober, K.E., et al.: Echocardiographic evaluation of left ventricular diastolic function in cats: Hemodynamic determinants and pattern recognition. J. Vet. Cardiol. 17, 102–133 (2015)
Spalla, I., et al.: Prognostic value of mitral annular systolic plane excursion and tricuspid annular plane systolic excursion in cats with hypertrophic cardiomyopathy. J. Vet. Cardiol. 20, 154–167 (2018)
Johns, S.M., et al.: Left atrial function in cats with left-sided cardiac disease and pleural effusion or pulmonary edema. J. Vet. Intern. Med. 26, 1134–1139 (2012)
Duler, L., et al.: Left atrial size and volume in cats with primary cardiomyopathy with and without congestive heart failure. J. Vet. Cardiol. 24, 36–47 (2019)
Genua, I., et al.: Centreline-based shape descriptors of the left atrial appendage in relation with thrombus formation. In: Pop, M., et al. (eds.) STACOM 2018. LNCS, vol. 11395, pp. 200–208. Springer, Cham (2019). https://doi.org/10.1007/978-3-030-12029-0_22
Aguado, A.M., et al.: In silico optimization of left atrial appendage occluder implantation using interactive and modeling tools. Front. Physiol. 10, 237 (2019)
Mill, J., et al.: Impact of flow dynamics on device-related thrombosis after left atrial appendage occlusion. Can. J. Cardiol. 36, 968-e13 (2020)
Simcock, I.C., et al.: Investigation of optimal sample preparation conditions with potassium triiodide and optimal imaging settings for microfocus computed tomography of excised cat hearts. Am. J. Vet. Res. 81, 326–333 (2020)
Lee, Y., et al.: Comparison of morphologic features and flow velocity of the left atrial appendage among patients with atrial fibrillation alone, transient ischemic attack, and cardioembolic stroke. Am. J. Cardiol. 119, 1596–1604 (2017)
Khurram, I.M., et al.: Relationship between left atrial appendage morphology and stroke in patients with atrial fibrillation. Heart Rhythm 10(12), 1843–1849 (2013)
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Olivares, A.L. et al. (2021). Shape Analysis and Computational Fluid Simulations to Assess Feline Left Atrial Function and Thrombogenesis. In: Ennis, D.B., Perotti, L.E., Wang, V.Y. (eds) Functional Imaging and Modeling of the Heart. FIMH 2021. Lecture Notes in Computer Science(), vol 12738. Springer, Cham. https://doi.org/10.1007/978-3-030-78710-3_59
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DOI: https://doi.org/10.1007/978-3-030-78710-3_59
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