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Multifaceted Effects of Ligand on Nuclear Receptor Mobility

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Nuclear Receptors

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Abstract

Members of the nuclear receptor superfamily function as both intracellular receptors and transcription factors, modulating transcription of target genes in response to hormone. In the classical model of steroid hormone action, after crossing the plasma membrane hormone binds to cytoplasmic pools of receptor that are then rapidly translocated to the nucleus to facilitate gene transcription. Extensive studies since then have revealed a far more complicated story. The nuclear receptors are remarkably dynamic proteins that can undergo rapid nucleocytoplasmic shuttling in the presence or absence of hormone. They display a diversity of distributions within the cell, showing variation in transport mechanisms between the cytoplasmic and nuclear compartments and in their intranuclear dynamics. This chapter highlights key features of three main categories of intracellular localization into which the nuclear receptors can be roughly sorted: ligand-dependent nuclear accumulation, ligand-dependent intranuclear localization, and ligand-independent trafficking.

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Acknowledgments

Research in the Allison lab is supported in part by Grant 2R15DK058028 from the National Institutes of Health to L.A.A.

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    Lizabeth A. Allison & Vincent R. Roggero

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  1. School of Pharmacy, University of Missouri-Kansas City, Kansas City, MO, USA

    Mostafa Z. Badr

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Allison, L.A., Roggero, V.R. (2021). Multifaceted Effects of Ligand on Nuclear Receptor Mobility. In: Badr, M.Z. (eds) Nuclear Receptors. Springer, Cham. https://doi.org/10.1007/978-3-030-78315-0_3

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