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Use of Nanotechnology to Improve 15d-PGJ2 Immunomodulatory Activities

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Nuclear Receptors

Abstract

A growing body of evidence demonstrates that 15-deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) which is an endogenous ligand of peroxisome proliferator-activated receptor gamma (PPAR-γ) has multiple physiological properties. It has been demonstrated the efficacy at low doses even lower when combined with nanotechnology, as a promising therapeutic approach as immunoresolvents and some of them present long-lasting anti-inflammatory effects. In this chapter, we focus on how 15d-PGJ2 is involved in the resolution of inflammatory responses and as potential analgesic molecule. Importantly, we will present evidences that nanotechnology (nanocarriers) is a helpful tool to improve its action and bioavailability.

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Authors and Affiliations

  1. Faculdade São Leopoldo Mandic, Instituto São Leopoldo Mandic, Laboratory of Neuro-Immune Interface of Pain Research, Campinas, SP, Brazil

    Marcelo H. Napimoga, Henrique B. Abdalla & Juliana T. Clemente-Napimoga

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  2. Henrique B. Abdalla
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  3. Juliana T. Clemente-Napimoga
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Correspondence to Marcelo H. Napimoga .

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  1. School of Pharmacy, University of Missouri-Kansas City, Kansas City, MO, USA

    Mostafa Z. Badr

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Napimoga, M.H., Abdalla, H.B., Clemente-Napimoga, J.T. (2021). Use of Nanotechnology to Improve 15d-PGJ2 Immunomodulatory Activities. In: Badr, M.Z. (eds) Nuclear Receptors. Springer, Cham. https://doi.org/10.1007/978-3-030-78315-0_19

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