Abstract
The discovery of PPARα led to a global explosion of scientific research in both academia and pharmaceutical companies. Almost 30 years later, this nuclear receptor remains an enigma. Here, I focus on the ligand-binding domain (LBD) of PPARα and chart a trajectory of landmark bioassays for receptor activation and ligand binding. What were the hurdles? And how were they addressed? The LBD facet is just a small part of the PPARα protein, but it plays a pivotal role in the functional machinations. It arguably symbolizes how the interplay of competition and collaboration between research groups is required to fuel discovery toward safe and effective medicines. Perhaps in reflection, we can bring some light to how the LBD of PPARα forms functions to direct dynamic fate.
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Acknowledgments
P.R.D. was funded in part by the K.A.S.H. Research Scientist in Preventative Medicine, the Leducq Foundation and NIH (AR002218).
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Devchand, P.R. (2021). Functional Bioassays Lithograph Ligand Reflections in the PPARα Sphere. In: Badr, M.Z. (eds) Nuclear Receptors. Springer, Cham. https://doi.org/10.1007/978-3-030-78315-0_11
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