Skip to main content

Is Segmentation Uncertainty Useful?

  • Conference paper
  • First Online:
Information Processing in Medical Imaging (IPMI 2021)

Part of the book series: Lecture Notes in Computer Science ((LNIP,volume 12729))

Included in the following conference series:

Abstract

Probabilistic image segmentation encodes varying prediction confidence and inherent ambiguity in the segmentation problem. While different probabilistic segmentation models are designed to capture different aspects of segmentation uncertainty and ambiguity, these modelling differences are rarely discussed in the context of applications of uncertainty. We consider two common use cases of segmentation uncertainty, namely assessment of segmentation quality and active learning. We consider four established strategies for probabilistic segmentation, discuss their modelling capabilities, and investigate their performance in these two tasks. We find that for all models and both tasks, returned uncertainty correlates positively with segmentation error, but does not prove to be useful for active learning.

Code available at github.com/SteffenCzolbe/probabilistic_segmentation.

S. Czolbe and K. Arnavaz—contributed equally.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 89.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Notes

  1. 1.

    For simplicity, we consider binary segmentation; the generalization to multi-class segmentation is straightforward.

References

  1. Armato III, S.G., et al.: The lung image database consortium (LIDC) and image database resource initiative (IDRI): a completed reference database of lung nodules on CT scans. Med. Phys. 38(2), 915–931 (2011)

    Article  Google Scholar 

  2. Clark, K., et al.: The cancer imaging archive (TCIA): maintaining and operating a public information repository. J. Digit. Imaging 26(6), 1045–1057 (2013)

    Article  Google Scholar 

  3. Codella, N.C., et al.: Skin lesion analysis toward melanoma detection: a challenge at the 2017 international symposium on biomedical imaging (ISBI), hosted by the international skin imaging collaboration (ISIC). In: 2018 IEEE 15th International Symposium on Biomedical Imaging, pp. 168–172 (2018)

    Google Scholar 

  4. Gal, Y., Ghahramani, Z.: Dropout as a Bayesian approximation: representing model uncertainty in deep learning. In: International Conference on Machine Learning, pp. 1050–1059 (2016)

    Google Scholar 

  5. Jungo, A., Reyes, M.: Assessing reliability and challenges of uncertainty estimations for medical image segmentation. In: Shen, D., et al. (eds.) MICCAI 2019. LNCS, vol. 11765, pp. 48–56. Springer, Cham (2019). https://doi.org/10.1007/978-3-030-32245-8_6

    Chapter  Google Scholar 

  6. Kohl, S., et al.: A probabilistic u-net for segmentation of ambiguous images. Adv. Neural Inf. Process. Syst. 31, 6965–6975 (2018)

    Google Scholar 

  7. Lewis, D.D., Catlett, J.: Heterogeneous uncertainty sampling for supervised learning. In: Machine Learning Proceedings 1994, pp. 148–156. Elsevier (1994)

    Google Scholar 

  8. Loog, M., Yang, Y.: An empirical investigation into the inconsistency of sequential active learning. In: 2016 23rd International Conference on Pattern Recognition (ICPR), pp. 210–215. IEEE (2016)

    Google Scholar 

  9. MacKay, D.J.: The evidence framework applied to classification networks. Neural Comput. 4(5), 720–736 (1992)

    Article  Google Scholar 

  10. MacKay, D.J.: Information-based objective functions for active data selection. Neural Comput. 4(4), 590–604 (1992)

    Article  Google Scholar 

  11. Monteiro, M., et al.: Stochastic segmentation networks: modelling spatially correlated aleatoric uncertainty. In: Larochelle, H., Ranzato, M., Hadsell, R., Balcan, M.F., Lin, H. (eds.) Advances in Neural Information Processing Systems, vol. 33, pp. 12756–12767 (2020)

    Google Scholar 

  12. Ronneberger, O., Fischer, P., Brox, T.: U-net: convolutional networks for biomedical image segmentation. In: Navab, N., Hornegger, J., Wells, W.M., Frangi, A.F. (eds.) MICCAI 2015. LNCS, vol. 9351, pp. 234–241. Springer, Cham (2015). https://doi.org/10.1007/978-3-319-24574-4_28

    Chapter  Google Scholar 

  13. Settles, B.: Active learning literature survey. University of Wisconsin-Madison Department of Computer Sciences. Technical report (2009)

    Google Scholar 

  14. Székely, G.J., Rizzo, M.L.: Energy statistics: a class of statistics based on distances. J. Stat. Plan. Infer. 143(8), 1249–1272 (2013)

    Article  MathSciNet  Google Scholar 

  15. Tschandl, P., Rosendahl, C., Kittler, H.: The HAM10000 dataset, a large collection of multi-source dermatoscopic images of common pigmented skin lesions. Sci. Data 5, 180161 (2018)

    Article  Google Scholar 

  16. Yang, Y., Loog, M.: A benchmark and comparison of active learning for logistic regression. Pattern Recogn. 83, 401–415 (2018)

    Article  Google Scholar 

Download references

Acknowledgements

Our data was extracted from the “ISIC 2018: Skin Lesion Analysis Towards Melanoma Detection” grand challenge datasets [3, 15]. The authors acknowledge the National Cancer Institute and the Foundation for the National Institutes of Health, and their critical role in the creation of the free publicly available LIDC/IDRI Database used here. This work was funded in part by the Novo Nordisk Foundation (grants no. NNF20OC0062606 and NNF17OC0028360) and the Lundbeck Foundation (grant no. R218-2016-883).

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Steffen Czolbe .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2021 Springer Nature Switzerland AG

About this paper

Check for updates. Verify currency and authenticity via CrossMark

Cite this paper

Czolbe, S., Arnavaz, K., Krause, O., Feragen, A. (2021). Is Segmentation Uncertainty Useful?. In: Feragen, A., Sommer, S., Schnabel, J., Nielsen, M. (eds) Information Processing in Medical Imaging. IPMI 2021. Lecture Notes in Computer Science(), vol 12729. Springer, Cham. https://doi.org/10.1007/978-3-030-78191-0_55

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-78191-0_55

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-78190-3

  • Online ISBN: 978-3-030-78191-0

  • eBook Packages: Computer ScienceComputer Science (R0)

Publish with us

Policies and ethics