Abstract
Type 1 diabetes (T1D) is an autoimmune disease that usually occurs in children and reduces their pancreatic islet beta cells and thereby limits insulin production. Millions of individuals worldwide have T1D, and the number of children with diagnosed or undiagnosed T1D is increasing annually. Insulin supplementation is not a cure. It does not halt the persistent autoimmune response nor can it reliably prevent devastating complications such as neuronal and cardiovascular diseases, blindness, and kidney failure. A true cure has proven elusive despite intensive research pressure over the past 25 years. Notably, Dr. Zhao and his team have successfully developed a groundbreaking technology, namely, stem cell educator therapy (Zhao Y, et al. BMC Medicine 2011, 2012). To date, clinical trials in adult patients have demonstrated the safety and efficacy of stem cell educator therapy for the treatment of T1D and other autoimmune-associated diseases. Here, the investigators will evaluate the safety and efficacy of stem cell educator therapy in children with type 1 diabetes.
The Second Xiangya Hospital, Changsha, Hunan, China
ClinicalTrials.gov Identifier: NCT01996228
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Weiss, J.N. (2022). Reversal of Type 1 Diabetes in Children by Stem Cell Educator Therapy. In: Stem Cell Surgery Trials in Heart Failure and Diabetes. Springer, Cham. https://doi.org/10.1007/978-3-030-78010-4_22
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DOI: https://doi.org/10.1007/978-3-030-78010-4_22
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