Skip to main content
  • 204 Accesses

Abstract

The concept of tissue regeneration and growth from a small subset of cell population has often been thought of as the gold standard for restoration of normal or pre-morbid tissue. Dating back to 1800s, scientists and surgeons alike have attempted to optimize not just autologous transfer of tissue, but autologous tissue expansion, growth, and regeneration. This chapter will briefly review the history of autologous fat transfer and subsequent discovery of adipose derived stem cells (ADSCs). It will broadly review current understanding of adipose derived stem cell differentiation as well as current utilization techniques and future applications.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 189.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 249.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 329.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Neuber GA. Fettransplantation. Chir Kongr Verhandl Deutsche Gesellschaft für Chir. 1893. p. 22.

    Google Scholar 

  2. Hollander E, Veriag von Velt JM. Cosmetic surgery. In: Josheph M, editor. Handbuch der Kosmetik. Germany: Leipzig, Veit & Co.; 1912. p. 690–1.

    Google Scholar 

  3. Lexer E. Freie fett transplantation. Dtsch Med Wochenschr. 1910;36:640.

    Google Scholar 

  4. Brunning P. Contribution à l’étude des greffes adipeuses. Bull Mem Acad R Med Belg. 1919.

    Google Scholar 

  5. Miller C. Cannula implants and review of implantation techniques in esthetic surgery. Am J Opthalmol. 1926;9(11):855.

    Google Scholar 

  6. Coleman SR. Long-term survival of fat transplant: controlled demonstrations. Aesthet Plast Surg. 1995;19:421–5.

    Article  CAS  Google Scholar 

  7. Coleman SR. Facial recontouring with lipostructure. Clin Plast Surg. 1997;24:347–67.

    Article  CAS  Google Scholar 

  8. Mazzola R. The fascinating history of fat grafting. J Craniofac Surg. 2013;24(4):1069–71.

    Article  Google Scholar 

  9. Zuk PA, Zhu M, Mizuno H, et al. Multilineage cells from human adipose tissue: implications for cell-based therapies. Tissue Eng. 2001;7:211–28.

    Article  CAS  Google Scholar 

  10. De Ugarte DA, Alfonso Z, Zuk PA, et al. Differential expression of stem cell mobilization-associated molecules on multi-lineage cells from adipose tissue and bone marrow. Immunol Lett. 2003;89(2–3):267–70.

    Article  Google Scholar 

  11. Glass GE, Ferretti P. Adipose-derived stem cells in aesthetic surgery. Aesthet Surg J. 2019;39(4):423–38.

    Article  Google Scholar 

  12. de Boer M, van Leeuwen FE, Hauptmann M, et al. Breast implants and the risk of anaplastic large-cell lymphoma in the breast. JAMA Oncol. 2018;4(3):335–41.

    Article  Google Scholar 

  13. Tonnard P. Nanofat grafting: basic research and clinical applications. Plast Reconstr Surg. 2013;132:1017–26.

    Article  CAS  Google Scholar 

  14. Wakako T. An animal model of local breast cancer recurrence in the setting of autologous fat grafting for breast reconstruction. Stem Cells Transl Med. 2018;7(1):125–1324.

    Article  Google Scholar 

  15. Park BS, Jang KA, Sung JH, et al. Adipose-derived stem cells and their secretory factors as a promising therapy for skin aging. Dermatol Surg. 2008;34(10):1323–6.

    CAS  PubMed  Google Scholar 

  16. Shin H, Ryu HH, Kwon O, Park BS, Jo SJ. Clinical use of conditioned media of adipose tissue-derived stem cells in female pattern hair loss: a retrospective case series study. Int J Dermatol. 2015;54(6):730–5.

    Article  Google Scholar 

  17. Borrelli MR. Radiation-induced skin fibrosis: pathogenesis, current treatment options, and emerging therapeutics. Ann Plast Surg. 2019;83(1):S59–64.

    Article  CAS  Google Scholar 

  18. Haas E. One-year outcomes of intraarticular fat transplantation for thumb carpometacarpal osteoarthritis. Plastic and Reconstructive Surgery. 2020;145(1):151–159.

    Google Scholar 

  19. Verhoekx J. Adipose-derived stem cells inhibit the contractile myofibroblast in Dupuytren’s disease. Plast Reconstr Surg J. 2013;132(5):1139–48.

    Article  CAS  Google Scholar 

  20. Erickson GR. Chondrogenic potential of adipose tissue-derived stromal cells in vitro and in vivo. Biochem Biophys Res Commun. 2002;290(2):763–9.

    Article  CAS  Google Scholar 

  21. Sowa Y. Adipose-derived stem cells promote peripheral nerve regeneration in vivo without differentiation into Schwann-like lineage. Plast Reconstr Surg. 2016;137(2):318e–30e.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2022 Springer Nature Switzerland AG

About this chapter

Cite this chapter

Burke, R.S., Nahai, F. (2022). The Era of Regenerative Surgery. In: Kalaaji, A. (eds) Plastic and Aesthetic Regenerative Surgery and Fat Grafting. Springer, Cham. https://doi.org/10.1007/978-3-030-77455-4_1

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-77455-4_1

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-77454-7

  • Online ISBN: 978-3-030-77455-4

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics