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Monitoring of Opioid Analgesic Use and Its Effects in Acute Care

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Opioid Use in Critical Care

Abstract

There has been a dramatic rise in deaths attributed to opioid use in the last decade, and with the recognition of prescription opioids as a significant contributor, the use of opioids in healthcare has become heavily scrutinized. However, despite a renewed interest in opioid sparing multimodal pain management strategies, opioids remain the most effective pain modality for severe acute pain. Also, with national guidelines emphasizing analgo-sedation (treat pain first), opioids are the cornerstone of sedation and analgesia practices in intensive care units. However, in the absence of appropriate cardiorespiratory monitoring, the side-effect profile of opioids can have dire consequences. Over the past decade, opioid consumption and adverse event prevention have been studied extensively with new technologies emerging to assist clinical decision making. Algorithms and protocols have been standardized taking many factors into consideration prior to subjectively determining if a verbal or nonverbal patient has adequate pain control. We here present an overview of the technology available to monitor opioid use and overdose, algorithms for various grades of sedation, personnel expertise, and certification required to safely administer opioids in acute care setting and methods to identify at-risk patient groups.

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Notes

  1. 1.

    Excerpted from Statement of Granting Privileges for Administration of Moderate Sedation to Practitioners, 2016, of the American Society of Anesthesiologists. A copy of the full text can be obtained from ASA, 1061 American Lane Schaumburg, IL 60173–4973 or online at www.asahq.org

  2. 2.

    Excerpted from Advisory on Granting Privileges for Deep Sedation to Non-Anesthesiologist Physicians, 2017, of the American Society of Anesthesiologists. A copy of the full text can be obtained from ASA, 1061 American Lane Schaumburg, IL 60173–4973 or online at www.asahq.org

References

  1. WHO Guidelines for the pharmacological and radiotherapeutic management of cancer pain in adults and adolescents. WHO Guidelines Approved by the Guidelines Review Committee. Geneva. 2018.

    Google Scholar 

  2. Practice Guidelines for Acute Pain Management in the Perioperative Setting. An updated report by the American Society of Anesthesiologists Task Force on acute pain management. Anesthe J Am Soc Anesthe. 2012;116(2):248–73.

    Google Scholar 

  3. Puntillo KA, Max A, Timsit J-F, Vignoud L, Chanques G, Robleda G, et al. Determinants of procedural pain intensity in the intensive care unit. The Europain® study. Am J Respir Crit Care Med. 2014;189(1):39–47.

    PubMed  Google Scholar 

  4. Gupta RK, Edwards DA. Monitoring for opioid-induced respiratory depression. Anesthe Pat Saf Found Newsl. 2018:(32)70–2.

    Google Scholar 

  5. Ayad S, Khanna AK, Iqbal SU, Singla N. Characterisation and monitoring of postoperative respiratory depression: current approaches and future considerations. Br J Anaesth. 2019;123(3):378–91.

    Article  Google Scholar 

  6. Anesthesiologists ASo. Continuum of depth of sedation: definition of general anesthesia and levels of sedation/analgesia. Approved by ASA House of Delegates on October 13, 1999, and last amended on October 15, 2014. 2014.

    Google Scholar 

  7. Sedation ASoATFo, Non-Anesthesiologists Ab. Practice guidelines for sedation and analgesia by non-anesthesiologists. Anesthesiology. 2002;96(4):1004–17.

    Article  Google Scholar 

  8. Care DMA. From moderate sedation/Analgesia (Conscious Sedation). Approved by the ASA House of Delegates on October. 2004;27.

    Google Scholar 

  9. Credentialing AHCo. Statement of granting privileges for Administration of moderate sedation to practitioners. In: Anesthesiologists ASo, editor. ; 2016.

    Google Scholar 

  10. Administration CoQMaD. In: Anesthesiologists ASo, editor. Advisory on granting privileges for deep sedation to non-anesthesiologist physicians; 2017.

    Google Scholar 

  11. Hjermstad MJ, Fayers PM, Haugen DF, Caraceni A, Hanks GW, Loge JH, et al. Studies comparing numerical rating scales, verbal rating scales, and visual analogue scales for assessment of pain intensity in adults: a systematic literature review. J Pain Symptom Manag. 2011;41(6):1073–93.

    Article  Google Scholar 

  12. Brochard L, Martin GS, Blanch L, Pelosi P, Belda FJ, Jubran A, et al. Clinical review: respiratory monitoring in the ICU-a consensus of 16. Crit Care. 2012;16(2):219.

    Article  Google Scholar 

  13. Barr J, Fraser GL, Puntillo K, Ely EW, Gelinas C, Dasta JF, et al. Clinical practice guidelines for the management of pain, agitation, and delirium in adult patients in the intensive care unit. Crit Care Med. 2013;41(1):263–306.

    Article  Google Scholar 

  14. Severgnini P, Pelosi P, Contino E, Serafinelli E, Novario R, Chiaranda M. Accuracy of critical care pain observation tool and behavioral pain scale to assess pain in critically ill conscious and unconscious patients: prospective, observational study. J Intensive Care. 2016;4(1):68.

    Article  Google Scholar 

  15. Puntillo K, Pasero C, Li D, Mularski RA, Grap MJ, Erstad BL, et al. Evaluation of pain in ICU patients. Chest. 2009;135(4):1069–74.

    Article  Google Scholar 

  16. Overdyk FJ, Dowling O, Marino J, Qiu J, Chien H-L, Erslon M, et al. Association of opioids and sedatives with increased risk of in-hospital cardiopulmonary arrest from an administrative database. PLoS One. 2016;11(2):e0150214.

    Article  Google Scholar 

  17. Rijkenberg S, Stilma W, Bosman RJ, van der Meer NJ, van der Voort PHJ. Pain measurement in mechanically ventilated patients after cardiac surgery: comparison of the behavioral pain scale (BPS) and the critical-care pain observation tool (CPOT). J Cardiothorac Vasc Anesth. 2017;31(4):1227–34.

    Article  Google Scholar 

  18. Apfelbaum JL, Horlocker TT, Agarkar M, Connis RT, Hebl JR, Nickinovich DG, et al. Practice guidelines for the prevention, detection, and Management of Respiratory Depression Associated with Neuraxialn Opioid Administration: an updated report by the American Society of Anesthesiologists Task Force on Neuraxial opioids and the American Society of Regional Anesthesia and Pain Medicine. Obstet Anesth Dig. 2017;37(1):11.

    Article  Google Scholar 

  19. Imhoff M, Kuhls S. Alarm algorithms in critical care monitoring. Anesth Analg. 2006;102(5):1525–37.

    Article  Google Scholar 

  20. Sjoding MW, Dickson RP, Iwashyna TJ, Gay SE, Valley TS. Racial Bias in pulse Oximetry measurement. N Engl J Med. 2020;383(25):2477–8.

    Article  Google Scholar 

  21. Weinger M. Dangers of postoperative opioids: APSF work- shop and white paper address prevention of postoperative respiratory complications. 2007. p. http://www.apsf.org/newsletters/html/2007/winter/01_opioidsOverdyk.htm.

  22. Overdyk FJ, Carter R, Maddox RR, Callura J, Herrin AE, Henriquez C. Continuous oximetry/capnometry monitoring reveals frequent desaturation and bradypnea during patient-controlled analgesia. Anesth Analg. 2007;105(2):412–8.

    Article  CAS  Google Scholar 

  23. Salottolo K, Carrick M, Johnson J, Gamber M, Bar-Or D. A retrospective cohort study of the utility of the modified early warning score for interfacility transfer of patients with traumatic injury. BMJ Open. 2017;7(5):e016143.

    Article  Google Scholar 

  24. Ronen M, Weissbrod R, Overdyk F, Ajizian S. Smart respiratory monitoring: clinical development and validation of the IPI™(integrated pulmonary index) algorithm. J Clin Monit Comput. 2017;31(2):435–42.

    Article  CAS  Google Scholar 

  25. Maddox RR, Williams CK, Oglesby H, Butler B, Colclasure B. Clinical experience with patient-controlled analgesia using continuous respiratory monitoring and a smart infusion system. Am J Health Syst Pharm. 2006;63(2):157–64.

    Article  Google Scholar 

  26. Patino M, Kalin M, Griffin A, Minhajuddin A, Ding L, Williams T, et al. Comparison of postoperative respiratory monitoring by acoustic and transthoracic impedance technologies in pediatric patients at risk of respiratory depression. Anesth Analg. 2017;124(6):1937–42.

    Article  CAS  Google Scholar 

  27. Van Loon K, Breteler M, Van Wolfwinkel L, Leyssius AR, Kossen S, Kalkman C, et al. Wireless non-invasive continuous respiratory monitoring with FMCW radar: a clinical validation study. J Clin Monit Comput. 2016;30(6):797–805.

    Article  Google Scholar 

  28. Khanna AK, Overdyk FJ, Greening C, Di Stefano P, Buhre WF. Respiratory depression in low acuity hospital settings-seeking answers from the PRODIGY trial. J Crit Care. 2018;47:80–7.

    Article  Google Scholar 

  29. Sun Z, Sessler DI, Dalton JE, Devereaux P, Shahinyan A, Naylor AJ, et al. Postoperative hypoxemia is common and persistent: a prospective blinded observational study. Anesth Analg. 2015;121(3):709.

    Article  CAS  Google Scholar 

  30. Hopf HW. Preventing Opioid-Induced Postoperative Hypoxemia: No Simple Answer? Anesth Analg. 2016;123(6):1356–58. https://doi.org/10.1213/ANE.

  31. Khanna AK, Sessler D, Sun Z, Naylor A, You J, Hesler B, et al. Using the STOP-BANG questionnaire to predict hypoxaemia in patients recovering from noncardiac surgery: a prospective cohort analysis. BJA: Br J Anaesth. 2016;116(5):632–40.

    Article  CAS  Google Scholar 

  32. Izrailtyan I, Qiu J, Overdyk FJ, Erslon M, Gan TJ. Risk factors for cardiopulmonary and respiratory arrest in medical and surgical hospital patients on opioid analgesics and sedatives. PLoS One. 2018;13(3):e0194553.

    Article  Google Scholar 

  33. Andersen LW, Berg KM, Chase M, Cocchi MN, Massaro J, Donnino MW. Acute respiratory compromise on inpatient wards in the United States: incidence, outcomes, and factors associated with in-hospital mortality. Resuscitation. 2016;105:123–9.

    Article  Google Scholar 

  34. Khanna A, Buhre W, Saager L, Stefano PD, Weingarten T, Dahan A, et al. 36: derivation and validation of a novel opioid-induced respiratory depression risk prediction tool. Crit Care Med. 2019;47(1):18.

    Article  Google Scholar 

  35. Wildemeersch D, Peeters N, Saldien V, Vercauteren M, Hans G. Pain assessment by pupil dilation reflex in response to noxious stimulation in anaesthetized adults. Acta Anaesthesiol Scand. 2018;62(8):1050–6.

    Article  CAS  Google Scholar 

  36. Gupta K, Prasad A, Nagappa M, Wong J, Abrahamyan L, Chung FF. Risk factors for opioid-induced respiratory depression and failure to rescue: a review. Curr Opin Anaesthesiol. 2018;31(1):110–9.

    Article  Google Scholar 

  37. Khanna AK, Hoppe P, Saugel B. Automated continuous noninvasive ward monitoring: future directions and challenges. Crit Care. 2019;23(1):194.

    Article  Google Scholar 

  38. Sessler DI, Saugel B. Beyond ‘failure to rescue’: the time has come for continuous ward monitoring. Br J Anaesth. 2019;122(3):304–6.

    Article  Google Scholar 

  39. Rao VK, Khanna AK. Postoperative respiratory impairment is a real risk for our patients: the intensivist’s perspective. Anesth Res Pract. 2018;2018:3215923.

    Google Scholar 

  40. Saugel B, Hoppe P, Khanna A. Automated continuous noninvasive ward monitoring: validation of measurement systems is the real challenge. Anesthesiology. 2020;132(3):407–10.

    Article  Google Scholar 

  41. Marik PE. Management of pain, agitation and delirium. Evidence-based critical care. Berlin: Springer International Publishing; 2015. p. 197–212.

    Google Scholar 

  42. Gehlbach B, Kress J. Pain control, sedation, and use of muscle relaxants. Principles of critical care. 3rd ed. New York: McGraw-Hill; 2005. p. 139–63.

    Google Scholar 

  43. Oropello JM, Kvetan V, Pastores SM. Lange critical Care. New York: McGraw-Hill Education; 2016.

    Google Scholar 

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Correspondence to Ashish K. Khanna .

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Patel, A., Karamchandani, K., Khanna, A.K. (2021). Monitoring of Opioid Analgesic Use and Its Effects in Acute Care. In: Pascual, J.L., Gaulton, T.G. (eds) Opioid Use in Critical Care. Springer, Cham. https://doi.org/10.1007/978-3-030-77399-1_7

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  • DOI: https://doi.org/10.1007/978-3-030-77399-1_7

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