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Astrocytes in Bipolar Disorder

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Astrocytes in Psychiatric Disorders

Part of the book series: Advances in Neurobiology ((NEUROBIOL,volume 26))

Abstract

Bipolar disorder (BD) is a complex group of neuropsychiatric disorders, typically comprising both manic and depressive episodes. The underlying neuropathology of BD is not established, but a consistent feature is progressive thinning of cortical grey matter (GM) and white matter (WM) in specific pathways, due to loss of subpopulations of neurons and astrocytes, with accompanying disturbance of connectivity. Dysregulation of astrocyte homeostatic functions are implicated in BD, notably regulation of glutamate, calcium signalling, circadian rhythms and metabolism. Furthermore, the beneficial therapeutic effects of the frontline treatments for BD are due at least in part to their positive actions on astrocytes, notably lithium, valproic acid (VPA) and carbamazepine (CBZ), as well as antidepressants and antipsychotics that are used in the management of this disorder. Treatments for BD are ineffective in a large proportion of cases, and astrocytes represent new therapeutic targets that can also serve as biomarkers of illness progression and treatment responsiveness in BD.

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Acknowledgements

We would like to thank the support of the BBSRC and MRC (AB), and the MSCA Seal of Excellence @ UNIPD (AR).

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Authors and Affiliations

  1. School of Pharmacy and Biomedical Science, University of Portsmouth, Portsmouth, UK

    Arthur M. Butt

  2. Department of Neuroscience, Institute of Human Anatomy, University of Padua, Padua, Italy

    Andrea D. Rivera

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  1. Arthur M. Butt
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  2. Andrea D. Rivera
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Correspondence to Arthur M. Butt .

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Editors and Affiliations

  1. Department of Forensic Analytical Toxicology, School of Forensic Medicine, China Medical University, Shenyang, China

    Baoman Li

  2. Department of Neurobiology, The University of Alabama at Birmingham, Birmingham, AL, USA

    Vladimir Parpura

  3. Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK

    Alexei Verkhratsky

  4. Department of Physiology and Pharmacology “Vittorio Erspamer”, Sapienza University of Rome, Rome, Italy

    Caterina Scuderi

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Butt, A.M., Rivera, A.D. (2021). Astrocytes in Bipolar Disorder. In: Li, B., Parpura, V., Verkhratsky, A., Scuderi, C. (eds) Astrocytes in Psychiatric Disorders. Advances in Neurobiology, vol 26. Springer, Cham. https://doi.org/10.1007/978-3-030-77375-5_5

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