Abstract
This chapter introduces the study of the etiopathogenic field of depression, i.e., the study of causes and pathways through which subjects become depressed. Our goal is not without difficulties. First of all, we encounter a theoretical problem: we still do not know well what mental illness consist of, and we don’t have a precise definition of what depression is; within psychiatric conditions, depression is particularly pleomorphic. On the other hand, empirical research has described a wide range of risk factors for psychiatric illness that led to a variety of etiopathogenic models (from genetics to sociocultural models) that have tended to develop more in isolation than in an integrated manner, which has diminished their heuristic capacity. Depression is better understood as a complex behavior of a complex system that depends on multiple causes and multiple levels of organization. Nevertheless, what remains to be known are the relationships between the properties and behaviors at the different levels. The aim of this introductory chapter is to review the clinical phenomenon we call depression by critically considering the main aspects of its psychopathological diagnosis and its conceptual history as well as to understand the epistemological relationship between the clinical picture and the various causal fields in psychiatry, proposing ways, and explaining difficulties for the integration of theories and models in depression, taking into account the most relevant findings of research. Finally, we conclude that it is necessary to develop empirical studies that include integrative models that account for the dynamic interaction between the different levels of causality.
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References
Akiskal, H. S. (1996). The prevalent clinical spectrum of bipolar disorders: Beyond DSM-IV. Journal of Clinical Psychopharmacology, 16(2 Suppl 1), 4S–14S. https://doi.org/10.1097/00004714-199604001-00002
Akiskal, K. K., & Akiskal, H. S. (2005). The theoretical underpinnings of affective temperaments: Implications for evolutionary foundations of bipolar disorder and human nature. Journal of Affective Disorders, 85(1–2), 231–239. https://doi.org/10.1016/j.jad.2004.08.002
Akiskal, H. S., & Pinto, O. (1999). The evolving bipolar spectrum. Prototypes I, II, III, and IV. The Psychiatric Clinics of North America, 22(3), 517–534, vii. Retrieved from http://www.sciencedirect.com/science/article/pii/S0193953X05700939
Akiskal, H. S., Djenderedjian, A. M., Rosenthal, R. H., & Khani, M. K. (1977). Cyclothymic disorder: Validating criteria for inclusion in the bipolar affective group. The American Journal of Psychiatry, 134(11), 1227–1233. https://doi.org/10.1176/ajp.134.11.1227
Angst, J. (2007). The bipolar spectrum. The British Journal of Psychiatry: the Journal of Mental Science, 190, 189–191. https://doi.org/10.1192/bjp.bp.106.030957
Angst, J., Merikangas, K. R., Cui, L., Van Meter, A., Ajdacic-Gross, V., & Rossler, W. (2018). Bipolar spectrum in major depressive disorders. European Archives of Psychiatry and Clinical Neuroscience, 268(8), 741–748. https://doi.org/10.1007/s00406-018-0927-x
Beauchaine, T. P., & Cicchetti, D. E. (2019). Emotion dysregulation. Development and Psychopathology, 31(3). https://doi.org/10.1017/S0954579419000415
Belsky, J., Bakermans-Kranenburg, M., & van Ijzendoorn, M. (2007). For better and for worse: Differential susceptibility to environmental influences. Current Directions in Psychological Science, 16, 300–304.
Belsky, J., & Pluess, M. (2009). Beyond diathesis stress: differential susceptibility to environmental influences. Psychological Bulletin, 135(6), 885–908. https://doi.org/10.1037/a0017376
Berrios, G. (2011). La epistemología de la psiquiatría. In Hacia una nueva epistemología de la psiquiatría (pp. 27–39). Polemos.
Berrios, G., & Porter, R. (1995). A history of clinical psychiatry. The Athlone Press.
Blatt, S. (2008). Polarities of experience. Relatedness and self-definition in personality development, psychopathology, and the therapeutic process. American Psychological Association.
Blatt, S. (2015). Depression. In P. Luyten, L. Mayes, P. Fonagy, M. Target, & S. Blatt (Eds.), Handbook of psychodynamic approaches to psychopathology (pp. 131–151). The Guilford Press.
Blatt, S. J., & Luyten, P. (2009). A structural-developmental psychodynamic approach to psychopathology: Two polarities of experience across the life span. Development and Psychopathology, 21(3), 793–814. https://doi.org/10.1017/S0954579409000431
Bolton, D. (2013). Should mental disorders be regarded as brain disorders? 21st century mental health sciences and implications for research and training. World Psychiatry, 12, 24–25. https://doi.org/10.1002/wps.20004
Boyce, W. T., & Ellis, B. J. (2005). Biological sensitivity to context: I. An evolutionary-developmental theory of the origins and functions of stress reactivity. Development and psychopathology, 17(2), 271–301.
Bromet, E., Andrade, L. H., Hwang, I., Sampson, N. A., Alonso, J., de Girolamo, G., … Kessler, R. C. (2011). Cross-national epidemiology of DSM-IV major depressive episode. BMC Medicine, 9, 90. https://doi.org/10.1186/1741-7015-9-90
Brown, G., & Harris, T. (1978). Social origins of depression. A study of psychiatric disorder in women. Free Press.
Brune, M. (2012). Does the oxytocin receptor (OXTR) polymorphism (rs2254298) confer ‘vulnerability’ for psychopathology or ‘differential susceptibility’? Insights from evolution. BMC Medicine, 10, 38. https://doi.org/10.1186/1741-7015-10-38
Burns, J. (2006). The social brain hypothesis of schizophrenia. World Psychiatry, 5(2), 77–81. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/16946939
Caspi, A., Houts, R. M., Belsky, D. W., Goldman-Mellor, S. J., Harrington, H., Israel, S., … Moffitt, T. E. (2014). The p factor: One general psychopathology factor in the structure of psychiatric disorders? Clinical Psychological Science: A Journal of the Association for Psychological Science, 2(2), 119–137. https://doi.org/10.1177/2167702613497473
Cassano, G. B., Frank, E., Miniati, M., Rucci, P., Fagiolini, A., Pini, S., . . . Maser, J. D. (2002). Conceptual underpinnings and empirical support for the mood spectrum. The Psychiatric Clinics of North America, 25(4), 699–712, v. Retrieved from http://www.sciencedirect.com/science/article/pii/S0193953X02000254
Cepoiu, M., McCusker, J., Cole, M. G., Sewitch, M., Belzile, E., & Ciampi, A. (2008). Recognition of depression by non-psychiatric physicians--a systematic literature review and meta-analysis. Journal of General Internal Medicine, 23(1), 25–36. https://doi.org/10.1007/s11606-007-0428-5
Cicchetti, D., & Rogosch, F. A. (1996). Equifinality and multifinality in developmental psychopathology. Development and Psychopathology, 8, 597–600.
Cole, J., McGuffin, P., & Farmer, A. E. (2008). The classification of depression: Are we still confused? The British Journal of Psychiatry: The Journal of Mental Science, 192(2), 83–85. https://doi.org/10.1192/bjp.bp.107.039826
Cuthbert, B. N., & Insel, T. R. (2013). Toward the future of psychiatric diagnosis: The seven pillars of RDoC. BMC Medicine, 11, 126. https://doi.org/10.1186/1741-7015-11-126
Davidson, R. J., Pizzagalli, D., Nitschke, J. B., & Putnam, K. (2002). Depression: Perspectives from affective neuroscience. Annual Review of Psychology, 53, 545–574. https://doi.org/10.1146/annurev.psych.53.100901.135148
Del Giudice, M. (2016). The life history model of psychopathology explains the structure of psychiatric disorders and the emergence of the p factor: A simulation study. Clinical Psychological Science, 4(2), 299–311. https://doi.org/10.1177/2167702615583628
Dietz, D. M., & Nestler, E. J. (2012). From father to offspring: Paternal transmission of depressive-like behaviors. Neuropsychopharmacology, 37(1), 311–312. https://doi.org/10.1038/npp.2011.167
Dunbar, R. I. (2009). The social brain hypothesis and its implications for social evolution. Annals of Human Biology, 36(5), 562–572. https://doi.org/10.1080/03014460902960289
Dunbar, R. I., & Shultz, S. (2007). Evolution in the social brain. Science, 317(5843), 1344–1347. https://doi.org/10.1126/science.1145463
Ehrenberg, A. (2010). La société du malaise. Ed. Odile Jacob.
Ellis, B. J., Essex, M. J., & Boyce, W. T. (2005). Biological sensitivity to context: II. Empirical explorations of an evolutionary-developmental theory. Development and psychopathology, 17(2), 303–328.
Engel, G. L. (1977). The need for a new medical model: A challenge for biomedicine. Science, 196, 129–136.
Fonagy, P. (2003). The interpersonal interpretive mechanism: the confluence of genetics and attachment theory in development. In V. Green (Ed.), Emotional development in psychoanalysis, attachment theory and neuroscience. creating connections (pp. 107–126). Brunner-Routledge.
Fonagy, P., & Campbell, C. (2019). Supporting the social triad. A commentary on “Keeping culture in mind: A systematic review and initial conceptualization of mentalizing from a cross-cultural perspective”. Clinical Psychology: Science and Practice, 26(4), e12305. https://doi.org/10.1111/cpsp.12305
Fonagy, P., Allison, E., & Campbell, C. (2019a). Mentalizing, resilience, and epistemic trust. In A. Bateman & P. Fonagy (Eds.), Handbook of mentalizing in mental health practice (2nd ed.). American Psychiatric Publishing.
Fonagy, P., Campbell, C., & Allison, E. (2019b). Mentalizing and therapeutic models. In A. Bateman & P. Fonagy (Eds.), Handbook of Mentalizing in mental health practice (2nd ed.). American Psychiatric Publishing.
Fossion, P., Leys, C., Vandeleur, C., Kempenaers, C., Braun, S., Verbanck, P., & Linkowski, P. (2015). Transgenerational transmission of trauma in families of holocaust survivors: The consequences of extreme family functioning on resilience, sense of coherence, anxiety and depression. Journal of Affective Disorders, 171, 48–53. https://doi.org/10.1016/j.jad.2014.08.054
Freud, S. (2000). Duelo y Melancolía. In Obras Completas (pp. 235–255). Amorrortu.
Fried, E. I. (2017). The 52 symptoms of major depression: Lack of content overlap among seven common depression scales. Journal of Affective Disorders, 208, 191–197.
Fried, E. I., & Nesse, R. M. (2015). Depression is not a consistent syndrome: An investigation of unique symptom patterns in the STAR* D study. Journal of Affective Disorders, 172, 96–102.
Ghaemi, S. N., Vohringer, P. A., & Vergne, D. E. (2012). The varieties of depressive experience: Diagnosing mood disorders. The Psychiatric Clinics of North America, 35(1), 73–86. https://doi.org/10.1016/j.psc.2011.11.008
Hardeveld, F., Spijker, J., De Graaf, R., Nolen, W. A., & Beekman, A. T. (2013). Recurrence of major depressive disorder and its predictors in the general population: Results from the Netherlands Mental Health Survey and Incidence Study (NEMESIS). Psychological Medicine, 43(1), 39–48. https://doi.org/10.1017/S0033291712002395
Hirschfeld, R. M. (2013). Personality and mood disorders. In M. Keller (Ed.), Clinical guide to depression and bipolar disorder. Findings from the collaborative depression study (Vol. 1, pp. 135–140). American Psychiatric Publishing.
Ikeda, M., Tanaka, S., Saito, T., Ozaki, N., Kamatani, Y., & Iwata, N. (2018). Re-evaluating classical body type theories: Genetic correlation between psychiatric disorders and body mass index. Psychological Medicine, 48(10), 1745–1748. https://doi.org/10.1017/S0033291718000685
Insel, T. R. (2006). Beyond efficacy: The STAR*D trial. The American Journal of Psychiatry, 163(1), 5–7. https://doi.org/10.1176/appi.ajp.163.1.5
Insel, T., Cuthbert, B., Garvey, M., Heinssen, R., Pine, D. S., Quinn, K., … Wang, P. (2010). Research domain criteria (RDoC): Toward a new classification framework for research on mental disorders. The American Journal of Psychiatry, 167(7), 748–751. https://doi.org/10.1176/appi.ajp.2010.09091379
Jaspers, K. (1996). Psicopatología General. Fondo de Cultura Económica.
Karasz, A. (2005). Cultural differences in conceptual models of depression. Social Science & Medicine, 60(7), 1625–1635. https://doi.org/10.1016/j.socscimed.2004.08.011
Kendler, K. (2005). Toward a philosophical structure for psychiatry. The American Journal of Psychiatry, 162(3), 433–440. https://doi.org/10.1176/appi.ajp.162.3.433
Kendler, K. (2008). Introduction: Why does psychiatry need philosophy? In K. Kendler & J. Parnas (Eds.), Philosophical issues in psychiatry. Explanation, phenomenology, and nosology (pp. 1–16). Johns Hopkins University Press.
Kendler, K. S. (2012). Levels of explanation in psychiatric and substance use disorders: Implications for the development of an etiologically based nosology. Molecular Psychiatry, 17(1), 11–21. https://doi.org/10.1038/mp.2011.70
Kendler, K. S. (2014). The structure of psychiatric science. The American Journal of Psychiatry, 171, 931–938.
Kendler, K. S. (2016). The phenomenology of major depression and the representativeness and nature of DSM criteria. The American Journal of Psychiatry, 173(8), 771–780. https://doi.org/10.1176/appi.ajp.2016.15121509
Kendler, K. S. (2020). The origin of our modern concept of depression-the history of melancholia from 1780-1880: A review. JAMA Psychiatry. https://doi.org/10.1001/jamapsychiatry.2019.4709
Kendler, K. S., Gardner, C. O., & Prescott, C. A. (2002). Toward a comprehensive developmental model for major depression in women. The American Journal of Psychiatry, 159(7), 1133–1145. https://doi.org/10.1176/appi.ajp.159.7.1133
Kendler, K. S., Prescott, C., Myers, J., & Neale, M. C. (2003). The structure of genetic and environmental risk factors for common psychiatric and substance use disorders in men and women. Archives of General Psychiatry, 60(9), 929–937. https://doi.org/10.1001/archpsyc.60.9.929
Kleinman, A. (2004). Culture and depression. The New England Journal of Medicine, 351(10), 951–953. https://doi.org/10.1056/NEJMp048078
Kraepelin, E. (2012). La locura maníaco-depresiva. Ergon.
Krishnan, V., & Nestler, E. J. (2010). Linking molecules to mood: New insight into the biology of depression. The American Journal of Psychiatry, 167(11), 1305–1320. https://doi.org/10.1176/appi.ajp.2009.10030434
Kuhn, T. (2007). La estructura de las revoluciones científicas. Fondo de Cultura Económica.
Laceulle, O. M., Vollebergh, W. A. M., & Ormel, J. (2015). The structure of psychopathology in adolescence: Replication of a general psychopathology factor in the TRAILS study. Clinical Psychological Science, 3(6). https://doi.org/10.1177/2167702614560750
Lahey, B. B., Zald, D. H., Perkins, S. F., et al. (2018). Measuring the hierarchical general factor model of psychopathology in young adults. International Journal of Methods in Psychiatric Research, 27, e1593. https://doi.org/10.1002/mpr.1593. LAHEY ET AL. 9of9.
Layard, R. (2012). Mental health: The new frontier for the welfare state. CEP 21st Birthday Lecture Series. Given on 6 March 2012. Available here: http://cep.lse.ac.uk/_new/research/wellbeing/default.asp
Liu, R. T. (2013). Stress generation: Future directions and clinical implications. Clinical Psychology Review, 33(3), 406–416. https://doi.org/10.1016/j.cpr.2013.01.005
Luyten, P. (2012). Depression. In A. Bateman & P. Fonagy (Eds.), (Vol. 1, pp. 385–417). American Psychiatric Publishing Inc.
Luyten, P., & Blatt, S. J. (2007). Looking back towards the future: Is it time to change the DSM approach to psychiatric disorders? The case of depression. Psychiatry, 70(2), 85–99. https://doi.org/10.1521/psyc.2007.70.2.85
Luyten, P., & Fonagy, P. (2018). The stress-reward-mentalizing model of depression: An integrative developmental cascade approach to child and adolescent depressive disorder based on the Research Domain Criteria (RDoC) approach. Clinical Psychology Review, 64, 87–98.
Luyten, P., Blatt, S., & Corveleyn, J. (2005). Introduction. In J. Corveleyn, P. Luyten, & S. Blatt (Eds.), The theory and treatment of depression. Towards a dynamic interactionism model (pp. 5–15). Leuven University Press.
Lyotard, J.-F. (2008). La condición posmoderna. Cátedra.
Macdonald, A. N., Goines, K. B., Novacek, D. M., & Walker, E. F. (2016). Prefrontal mechanisms of comorbidity from a transdiagnostic and ontogenic perspective. Development and Psychopathology, 28(4pt1), 1147–1175. https://doi.org/10.1017/S0954579416000742
Maj, M. (2012). Development and validation of the current concept of major depression. Psychopathology, 45(3), 135–146. https://doi.org/10.1159/000329100
Makari, G. (2008). Revolution in mind: The creation of psychoanalysis (1st ed.). Harper.
Mann, J. J. (2010). Clinical pleomorphism of major depression as a challenge to the study of its pathophysiology. World Psychiatry, 9(3), 167–168. Retrieved from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948726/pdf/wpa030167.pdf
Markova, I. S., & Berrios, G. E. (2012). Epistemology of psychiatry. Psychopathology, 45(4), 220–227. https://doi.org/10.1159/000331599
Martel, M. M., Pan, P. M., Hoffmann, M. S., Gadelha, A., do Rosario, M. C., Mari, J. J., … Salum, G. A. (2017). A general psychopathology factor (P factor) in children: Structural model analysis and external validation through familial risk and child global executive function. Journal of Abnormal Psychology, 126(1), 137–148. https://doi.org/10.1037/abn0000205
Mayberg, H. S. (2007). Defining the neural circuitry of depression: Toward a new nosology with therapeutic implications. Biological Psychiatry, 61(6), 729–730. https://doi.org/10.1016/j.biopsych.2007.01.013
Mitchell, S. (2008). Explaining complex behavior. In K. Kendler & J. Parnas (Eds.), Philosophical issues in psychiatry (pp. 19–47). Johns Hopkins University Press.
Monroe, S. M., & Simons, A. D. (1991). Diathesis-stress theories in the context of life stress research: implications for the depressive disorders. Psychological bulletin, 110(3), 406–425.
Moras, K. (2006). Twenty-five years of psychological treatment research on unipolar depression in adult outpatients: Introduction to the special section. Psychotherapy Research, 16(5), 519–525.
Morin, E. (2011). Introducción al pensamiento complejo. Gedisa.
Murray, A. L., Eisner, M., & Ribeaud, D. (2016). The development of the general factor of psychopathology ‘p factor’ through childhood and adolescence. Journal of Abnormal Child Psychology, 44(8), 1573–1586. https://doi.org/10.1007/s10802-016-0132-1
Musalek, M., Larach-Walters, V., Lépine, J. P., Millet, B., & Gaebel, W. (2010). On behalf of the WFSBP task force on nosology and psychopathology. Psychopathology in the 21st century. The World Journal of Biological Psychiatry, 11, 844–851.
Nanni, V., Uher, R., & Danese, A. (2012). Childhood maltreatment predicts unfavorable course of illness and treatment outcome in depression: A meta-analysis. The American Journal of Psychiatry, 169(2), 141–151.
Nimnuan, C., Hotopf, M., & Wessely, S. (2001). Medically unexplained symptoms: An epidemiological study in seven specialities. Journal of Psychosomatic Research, 51, 361–367.
Olbert, C. M., Gala, G. J., & Tupler, L. A. (2014). Quantifying heterogeneity attributable to polythetic diagnostic criteria: Theoretical framework and empirical application. Journal of Abnormal Psychology, 123(2), 452.
Parker, G., Fink, M., Shorter, E., Taylor, M. A., Akiskal, H., Berrios, G., … Swartz, C. (2010). Issues for DSM-5: Whither melancholia? The case for its classification as a distinct mood disorder. The American Journal of Psychiatry, 167(7), 745–747. https://doi.org/10.1176/appi.ajp.2010.09101525
Patten, S. B. (2013). Major depression epidemiology from a diathesis-stress conceptualization. BMC psychiatry, 13, 19. https://doi.org/10.1186/1471-244X-13-19
Robins, E., & Guze, S. B. (1970). Establishment of diagnostic validity in psychiatric illness: Its application to schizophrenia. The American Journal of Psychiatry, 126(7), 983–987. https://doi.org/10.1176/ajp.126.7.983
Safford, M. M., Allison, J. J., & Kiefe, C. I. (2007). Patient complexity: More than comorbidity. The vector model of complexity. Journal of General Internal Medicine, 22(Suppl 3), 382–390. https://doi.org/10.1007/s11606-007-0307-0
Saveanu, R. V., & Nemeroff, C. B. (2012). Etiology of depression: genetic and environmental factors. The Psychiatric clinics of North America, 35(1), 51–71. https://doi.org/10.1016/j.psc.2011.12.001
Schaink, A. K., Kuluski, K., Lyons, R. F., Fortin, M., Jadad, A. R., Upshur, R., & Wodchis, W. P. (2012). A scoping review and thematic classification of patient complexity: Offering a unifying framework. Journal of Comorbidity, 2, 1–9. https://doi.org/10.15256/joc.2012.2.15
Schneider, K. (1997). Psicopatología Clínica. Fundación Archivos de Neurobiología.
Scott, K. M., McLaughlin, K. A., Smith, D. A., & Ellis, P. M. (2012). Childhood maltreatment and DSM-IV adult mental disorders: Comparison of prospective and retrospective findings. The British Journal of Psychiatry, 200(6), 469–475. https://doi.org/10.1192/bjp.bp.111.103267
Selzam, S., Coleman, J., Caspi, A., Moffitt, T., & Plomin, R. (2018). A polygenic p factor for major psychiatric disorders. Translational Psychiatry, 8(1), 205. https://doi.org/10.1038/s41398-018-0217-4
Shippee, N. D., Shah, N. D., May, C. R., Mair, F. S., & Montori, V. M. (2012). Cumulative complexity: A functional, patient-centered model of patient complexity can improve research and practice. Journal of Clinical Epidemiology, 65, 1041–1051. https://doi.org/10.1016/j.jclinepi.2012.05.005
Slavich, G. M., & Cole, S. W. (2013). The emerging field of human social genomics. Clinical Psychological Science, 1(3), 331–348. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/23853742
Starr, L. R., Conway, C. C., Hammen, C. L., & Brennan, P. A. (2014). Transdiagnostic and disorder-specific models of intergenerational transmission of internalizing pathology. Psychological Medicine, 44(1), 161–172. https://doi.org/10.1017/S003329171300055X
Sullivan, P. F., Neale, M. C., & Kendler, K. S. (2000). Genetic epidemiology of major depression: review and meta-analysis. The American Journal of Psychiatry, 157(10), 1552–1562.
Taylor, D. (2009). Consenting to be robbed so as not to be murdered. Psychoanalytic Psychotherapy, 23(3), 263–275.
Taylor, M. A., & Fink, M. (2008). Restoring melancholia in the classification of mood disorders. Journal of Affective Disorders, 105(1–3), 1–14. https://doi.org/10.1016/j.jad.2007.05.023
Teicher, M. H., & Samson, J. A. (2013). Childhood maltreatment and psychopathology: A case for ecophenotypic variants as clinically and neurobiologically distinct subtypes. The American Journal of Psychiatry, 170(10), 1114–1133.
Tellenbach, H. (1976). La Melancolía. Visión histórica del problema: endogeneidad, tipología, patogenia y clínica. Morata.
Thakker, J., & Ward, T. (1998). Culture and classification: The cross-cultural application of the DSM-IV. Clinical Psychology Review, 18(5), 501–529. https://doi.org/10.1016/s0272-7358(97)00107-4
van Loo, H. M., de Jonge, P., Romeijn, J. W., Kessler, R. C., & Schoevers, R. A. (2012). Data-driven subtypes of major depressive disorder: A systematic review. BMC Medicine, 10, 156. https://doi.org/10.1186/1741-7015-10-156
Vazquez, G. H., Tondo, L., Mazzarini, L., & Gonda, X. (2012). Affective temperaments in general population: A review and combined analysis from national studies. Journal of Affective Disorders, 139(1), 18–22. https://doi.org/10.1016/j.jad.2011.06.032
W.H.O. (2008). The Global Burden of Disease: 2004 (update).
Wurzman, R., & Giordano, J. (2012). Differential susceptibility to plasticity: A ‘missing link’ between gene-culture co-evolution and neuropsychiatric spectrum disorders? BMC Medicine, 10, 37. https://doi.org/10.1186/1741-7015-10-37
Zimmerman, M., Ellison, W., Young, D., Chelminski, I., & Dalrymple, K. (2015). How many different ways do patients meet the diagnostic criteria for major depressive disorder? Comprehensive Psychiatry, 56, 29–34.
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Jiménez, J.P., Botto, A., Fonagy, P. (2021). The Study of Depression in the Frame of the New Research Paradigm in Psychiatry. In: Jiménez, J.P., Botto, A., Fonagy, P. (eds) Etiopathogenic Theories and Models in Depression. Depression and Personality. Springer, Cham. https://doi.org/10.1007/978-3-030-77329-8_1
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