Skip to main content

Open Kyphoplasty and its Role in “Separation Surgery”

  • Chapter
  • First Online:
Vertebral Body Augmentation, Vertebroplasty and Kyphoplasty in Spine Surgery

Abstract

Different surgical options are available for the heterogeneous clinical conditions related to neoplastic spinal disorders and must be individualized to the specific needs of the single patient. Whenever excisional procedures like somatectomy, vertebrectomy, and extensive posterior stabilization are contraindicated in MSD, less invasive techniques, like percutaneous stabilization, endoscopic or minimal access surgical approaches, vertebroplasty, balloon kyphoplasty with their technical variations, may represent effective alternatives for intractable pain and/or mechanical instability. An Open Kyphoplasty (OKP), which includes a decompressive unilateral or bilateral laminectomy usually associated to a contralateral kyphoplasty, with or without a percutaneous posterior stabilization, may represent an intermediate and flexible solution which may be taken in consideration in patients with (1) a significant violation of the involved posterior vertebral wall; (2) an epidural tumor invasion; (3) an aggressive stage of disease, multiple vertebral lesions or poor prognosis; and (4) a general medical conditions precluding complex surgery. Minimal invasive techniques in conjunction with SSRS, have been recently advocated and seem very effective, even in case of significant epidural spinal cord impingement. Following the principles of “Separation Surgery,” the main goal of treatment has become to stabilize the column, to decompress the nervous structures and to create a safe distance (at least 2–3 mm), between the tumor and the cord as well as an adequate ablative target for SSRS. Reported tumor control rates of this new therapeutic strategy reach 85–90%, regardless of cancer histology.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 89.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Altaf F, Weber M, Dea N, et al. Evidence-based review and survey of expert opinion of reconstruction of metastatic spine tumors. Spine. 2016;41(20S):S254–62.

    Article  PubMed  Google Scholar 

  • Amankulor NM, Xu R, Iorgulesco JB, et al. The incidence and patterns of hardware failure after separation surgery in patients with spinal metastatic tumors. Spine J. 2014;14:1850–9.

    Article  PubMed  Google Scholar 

  • Barzilai O, Fisher CG, Bilsky MH. State of the art treatment of spinal metastatic disease. Neurosurgery. 2018a;82:757–69.

    Article  PubMed  Google Scholar 

  • Barzilai O, McLaughlin L, Amato MK, et al. Minimal access surgery for spinal metastases: prospective evaluation of a treatment algorithm using patient-reported outcomes. World Neurosurg. 2018b;120:e889–901.

    Article  PubMed  PubMed Central  Google Scholar 

  • Barzilai O, McLaughlin L, Lis E, et al. Outcome analysis of surgery for symptomatic spinal metastases in long-term cancer survivors. J Neurosurg Spine. 2019;26:1–6.

    Google Scholar 

  • Barzilai O, Bilsky M, Laufer I. The role of minimal access surgery in the treatment of spinal metastatic tumors. Global Spine J. 2020;10(2S):79S–87S.

    Article  PubMed  PubMed Central  Google Scholar 

  • Berenson J, Pflugmacher R, Jarzem P, Zonder J, Schechtman K, Tillman J, et al. Ballon kyphoplasty versus non-surgical fracture management for treatment of painful vertebral body compression fractures in patients with cancer: a multicentre, randomized controlled trial. Lancet Oncol. 2011;12:225–35.

    Article  PubMed  Google Scholar 

  • Bilsky MH, Boland P, Lis E, Raizer JJ, Healey JH. Single stage posterolateral transpedicle approach for spondylectomy, epidural decompression, and circumferential fusion for spinal metastases. Spine. 2000;25:2240–50.

    Article  CAS  PubMed  Google Scholar 

  • Bilsky MH, Laufer I, Fourney DR, Groff M, Schmidt MH, Varga PP, Vrionis FD, Yamada Y, Gerszten PC, Kuklo TR. Reliability analysis of the epidural spinal cord compression scale. J Neurosurg Spine. 2010;13(3):324–8.

    Article  PubMed  Google Scholar 

  • Boszczyk BM, Bierschneider M, Schmid K, Grillhosl A, Robert B, Jaksche H. Microsurgical interlaminary vertebro-and kyphoplasty for severe osteoporotic fractures. J Neurosurg Spine. 2004;100:32–7.

    Article  Google Scholar 

  • Bouras T, Zairi F, Arikat A, Vieillard MH, Allaoui M, Assaker R. Decision making for the surgical treatment of vertebral metastases among patients with short predicted survival. World Neurosurg. 2018;111:e573–80.

    Article  PubMed  Google Scholar 

  • Bouza C, Lopez-Cuadrado T, Cediel P, Saz-Parkinson Z, Amate JM. Ballon kyphoplasty in malignant spinal fractures: a systematic review and meta-analysis. BMC Palliat Care. 2009;8:12.

    Article  PubMed  PubMed Central  Google Scholar 

  • Burton AW, Mendoza T, Gebhardt R, Hamid B, Nouri K, Perez-Toro M, et al. Vertebral compression fracture treatment with vertebroplasty and kyphoplasty: experience in 407 patients with 1156 fracture in a tertiary cancer center. Pain Med. 2011;12:1750–7.

    Article  PubMed  Google Scholar 

  • Chang JH, Shin JH, Yamada YJ, et al. Stereotactic body radiotherapy for spinal metastases. What are the risks and how do we minimize them? Spine. 2016;41(20S):S238–45.

    Article  PubMed  PubMed Central  Google Scholar 

  • Chen I, Yang H, Tang T. Unilateral versus bilateral balloon kyphoplasty for multi-level osteoporotic vertebral compression fractures: a prospective study. Spine. 2011;36(7):534–40.

    Article  PubMed  Google Scholar 

  • Chew C, Craig L, Edwards R, Moss J, O’Dwyer PJ. Safety and efficacy of percutaneous vertebroplasty in malignancy: a systematic review. Clin Radiol. 2011;66:63–72.

    Article  CAS  PubMed  Google Scholar 

  • Choi D, Bilsky M, Fehlings M, Fisher C, Gokaslan Z. Spine oncology and metastatic spine tumors. Neurosurgery. 2017;80:S131–7.

    Article  PubMed  Google Scholar 

  • Conti A, Acker G, Kluge A, Loebel F, Kreimeier A, Budach V, Vajkoczy P, Ghetti I, Germano AF, Senger C. Decision making in patients with metastatic spine. The role of minimally invasive treatment modalities. Front Oncol. 2019;9:915.

    Article  PubMed  PubMed Central  Google Scholar 

  • Donnelly DJ, Add-El-Barr AA, Lu Y. Minimally invasive muscle sparing posterior only approach for lumbar circumferential decompression and stabilization to treat spine metastasis-technical report. World Neurosurg. 2015;84(5):1484–90.

    Article  PubMed  Google Scholar 

  • Drakhshandeh D, Miller JA, Fabiano AJ. Instrumented spinal stabilization without fusion for spinal metastatic disease. World Neurosurg. 2018;111:e403–9.

    Article  PubMed  Google Scholar 

  • Fisher CG, Di Paola CP, Ryken TC, et al. A novel classification system for spinal instability in neoplastic disease: an evidence-based approach and expert consensus from the spine oncologic study group. Spine. 2010;35:E1221–9.

    Article  PubMed  Google Scholar 

  • Fourney DR, Schomer DF, Nader R, et al. Percutaneous vertebropalsty and kyphoplasty for painful vertebral body fracture in cancer patients. J Neurosurg. 2003;98(suppl 1):21–30.

    PubMed  Google Scholar 

  • Fuentes S, Metellus P, Pech-Gourg G, Adetchessi T, Dufour H, Grisoli F. Open kypho- plasty for management of metastatic spine fracture. Neurochirurgie. 2007;53:49–53.

    Article  CAS  PubMed  Google Scholar 

  • Fuentes S, Blondel B, Metellus P, Adetchessi T, Gaudart J, Dufour H. Open kyphoplasty for management of severe osteoporotic spinal fractures. Neurosurgery. 2009;64(5 suppl 2):350–4.

    PubMed  Google Scholar 

  • Garg AK, Shiu AS, Yang J, Wang XS, Allen P, Brown BW, Grossman P, Frija EK, McAleer MF, Azeem S, Brown PD, Rhines LD, Chang EL. Phase 1/2 trial of single-session stereotactic body radiotherapy for previously unirradiated spinal metastases. Cancer. 2012;118(20):5069–77.

    Article  PubMed  Google Scholar 

  • Gerszten PC, Monaco EA. Complete percutaneous treatment of vertebral body tumors causing spinal canal compromise using transpedicular cavitation, cement augmentatio, and radiosurgical technique. Neurosurg Focus. 2009;27(6):E9.

    Article  PubMed  Google Scholar 

  • Gerszten PC, Germanwala A, Burton SA, Welch WC, Ozhasoglu C, Vogel WJ. Combination kyphoplasty and spinal radiosurgery. A new treatment paradigm for pathologial fractures. Neurosurg Focus. 2005;18(3):E8.

    Article  PubMed  Google Scholar 

  • Gerszten PC, Mendel E, Yamada Y. Radiotherapy and radiosurgery for metastatic spine disease: what are the options, indications, and outcomes? Spine. 2009;34(22 Suppl):S78–92.

    Article  PubMed  Google Scholar 

  • Gokaslan ZL, York JE, Walsh GL, McCutcheon IE, Lang FF, Putnam JB Jr, et al. Transthoracic vertebrectomy for metastatic spinal tumors. J Neurosurg. 1998;89:599–609.

    Article  CAS  PubMed  Google Scholar 

  • Hessler C, Vettorazzi E, Madert J, et al. Actual and predicted survival time of patients with spinal metastases of lung cancer: evaluation of the robustness of the Tokuhashi score. Spine. 2011;36(12):983–9.

    Article  PubMed  Google Scholar 

  • Hsiang J. An unconventional indication for open kyphoplasty. Spine J. 2003;3:520–3.

    Article  PubMed  Google Scholar 

  • Husain ZA, Sahgal A, Chang EL, Maralani PJ, Kubicky CD, Redmond KJ, Fisher C, Laufer I, Lo SS. Modern approaches to the management of metastatic epidural spinal cord compression. CNS Oncol. 2017;6(3):231–41.

    Article  CAS  PubMed Central  Google Scholar 

  • Jacobs WB, Perrin RG. Evaluation and treatment of spinal metastases: an overview. Neurosurg Focus. 2001;11(6):e10.

    Article  CAS  PubMed  Google Scholar 

  • Kasperk C, Haas A, Hillengass J, Weiss C, Neben K, Goldschmidt H, Sommer U, Nawroth P, Meeder PJ, Wiedenhöfer B, Schmidmaier G, Tanner M, Neuhof D, Nöldge G, Grafe IA. Kyphoplasty in patients with multiple myeloma a retrospective comparative pilot study. J Surg Oncol. 2012;105(7):679–86.

    Article  PubMed  Google Scholar 

  • Katagiri H, Okada R, Takagi T, et al. New prognostic factors and scoring system for patients with skeletal metastasis. Cancer Med. 2014;3(5):1359–67.

    Article  PubMed  PubMed Central  Google Scholar 

  • Klimo P Jr, Schmidt MH. Surgical management of spinal metastases. Oncologist. 2004;9:188–96.

    Article  PubMed  Google Scholar 

  • Kumar N, Malhotra R, Zaw AS, Maharajan K, Naresh N, Kumar A, et al. Evolution in treatment strategy for metastatic spine disease: presently evolving modalities. EJSO. 2017;43:1784–801.

    Article  CAS  PubMed  Google Scholar 

  • La Maida GA, Sala F, Callea G, Capitani D, Singh S. Efficacy of unipedicular balloon kyphoplasty for treatment of multiple myeloma vertebral lesions. Asian Spine J. 2011;5:162–8.

    Article  PubMed  PubMed Central  Google Scholar 

  • Laufer I, Rubin DG, Lis E, et al. The NOMS framework: approach to the treatment of spinal metastatic tumors. Oncologist. 2013;18:744–51.

    Article  PubMed  PubMed Central  Google Scholar 

  • Laufer I, Iorgulesu JB, Chapman T, et al. Local disease control for spinal metastases following “separation surgery” and adjuvant hypofractio- nated or high-dose single fraction stereotactic radiosurgery: outcome analysis of 186 patients. J Neurosurg Spine. 2014;18:207–14.

    Article  Google Scholar 

  • Lee MJ, Dumonsky M, Cahill P, Stanley T, Park D, Singh K. Percutaneous treatment of vertebral compression fractures: a meta-analysis of complications. Spine. 2009;34(11):1228–32.

    Article  Google Scholar 

  • Lee CH, Chung CK, Jahng TA, et al. Which one is a valuable surrogate for predicting survival between Tomita and Tokuhashi scores in patients with spinal metastases? A meta-analysis for diagnostic test accuracy and individual participant data analysis. J Neurooncol. 2015;123(2):267–75.

    Article  PubMed  Google Scholar 

  • Lovelock DM. Correlation of local failure with measures of dose insufficiency in the high-dose single-fraction treatment of bony metastases. Int J Radiat Oncol Biol Phys. 2010;77:1282–7.

    Article  PubMed  PubMed Central  Google Scholar 

  • Marco RAW, Meyer BC, Kushwaha VP. Thoracolumbar burst fractures treated with posterior decompression and pedicle screw instrumentation supplemented with balloon-assisted vertebroplasty and calcium phosphate reconstruction. J Bone Joint Surg Am. 2010;92(Suppl 1):67–76.

    Article  PubMed  Google Scholar 

  • McGirt MJ, Garcés-Ambrossi GL, Parker SL, Sciubba DM, Bydon A, Wolinksy JP, et al. Short-term progressive spinal deformity following laminoplasty versus laminectomy for resection of intradural spinal tumors: analysis of 238 patients. Neurosurgery. 2010;66:1005–12.

    Article  PubMed  Google Scholar 

  • Mendel E, Bourekas E, Gerszten P, et al. Percutaneous techniques in the treatment of spine tumors: what are the diagnosis and therapeutic indications and outcomes? Spine. 2009;34(22 Suppl):S93–S100.

    Article  PubMed  Google Scholar 

  • Moulding HD, Elder JB, Lis E, et al. Local disease control after decompressive surgery and adjuvant high dose single-fraction radiosurgery for spine metastases. J Neurosurg Spine. 2010;13:87–93.

    Article  PubMed  Google Scholar 

  • Moussazadeh N, Laufer I, Yamada Y, Bilsky MH. Separation surgery for spinal metastases: effect of spinal radiosurgery on surgical treatment goals. Cancer Control. 2014;21(2):168–74.

    Article  PubMed  Google Scholar 

  • Papanastassiou ID, Eleraky M, Murtagh R, et al. Comparison of unilateral versus bilateral Kyphoplasty in multiple myeloma patients and the importance of preoperative planning. Asian Spine J. 2014a;8(3):244–52.

    Article  PubMed  PubMed Central  Google Scholar 

  • Papanastassiou ID, Filis AK, Gerochristou MA. Controversial issues in kyphoplasty and vertebroplasty in malignant vertebral fractures. Cancer Control. 2014b;21:151–7.

    Article  PubMed  Google Scholar 

  • Patchell RA, Tibbs PA, Regine WF, et al. Direct decompressive surgical resection in the treatment of metastatic epidural spinal cord compression caused by metastatic cancer: a randomized trial. Lancet. 2005;366:643–8.

    Article  PubMed  Google Scholar 

  • Pompili A, Caroli F, Crispo F, Giovannetti M, Raus L, Vidiri A, Telera S. Unilateral laminectomy approach for the removal of spinal Meningiomas and schwannomas: impact on pain, spinal stability, and neurologic results. World Neurosurg. 2016;85:282–91.

    Article  PubMed  Google Scholar 

  • Rock JP, Ryu S, Shukairy MS, Yin FF, Sharif A, Schreiber F, Abdulhak M, Kim JH, Rosenblum ML. Postoperative radiosurgery for malignant spinal tumors. Neurosurgery. 2006;58(5):891–8.

    Article  PubMed  Google Scholar 

  • Ruiz Santiago F, Chinchilla AS, Alvarez LG, Abela ALP, Castellano Garcia MM, Lopez MP. Comparative review of vertebroplasty and kyphoplasty. World J Radiol. 2014;6(6):329–43.

    Article  PubMed  PubMed Central  Google Scholar 

  • Sahgal A, Roberge D, Shellenberg D, et al. The Canadian Association of Radiation Oncology scope of practice guidelines for lung, liver and spine stereotactic body radiotherapy. Clin Oncol (R Coll Radiol). 2012;24:629–39.

    Article  CAS  Google Scholar 

  • Singh K, Heller JG, Samartzis D, Scott Price J, An H, Yoon ST, Rhee J, Ledlie JT, Phillips FM. Open vertebral cement augmentation combined with lumbar decompression for the operative management of thoracolumbar stenosis secondary to osteoporotic burst fractures. J Spinal Disord Tech. 2005;18:413–9.

    Article  PubMed  Google Scholar 

  • Song CW, Kim MS, Cho LC, Dusenbery K, Sperduto PW. Radiobiological basis of SBRT and SRS. Int J Clin Oncol. 2014;19(4):570–8.

    Article  CAS  PubMed  Google Scholar 

  • Steinmann J, Tingey CT, Cruz G, Dai Q. Biomechanical comparison of unipedicular versus bipedicular kyphoplasty. Spine. 2005;2:201–5.

    Article  Google Scholar 

  • Sundaresan N, Steinberger AA, Moore F, Sachdev VP, Krol G, Hough L, Kelliher K. Indications and results of combined anterior-posterior approaches for spine tumor surgery. J Neurosurg. 1996;85(3):438–46.

    Article  CAS  PubMed  Google Scholar 

  • Tancioni F, Navarria P, Pessina F, Marcheselli S, Rognone E, Mancosu P, et al. Early surgical experience with minimally invasive percutaneous approach for patients with metastatic epidural spinal cord compression (MESCC) to poor prognoses. Ann Surg Oncol. 2012;19(1):294–300.

    Article  PubMed  Google Scholar 

  • Telera S, Gorgoglione N, Raus L, Vidiri A, Villani V, Pace A, Fabi A, Crispo F, Castiglione M, Sperduti I, Boccaletti R. Open Kyphoplasty for metastatic spine disease: a retrospective clinical series. World Neurosurg. 2019;127:e751–60.

    Article  PubMed  Google Scholar 

  • Thibault I, Chang EL, Sheehan J, et al. Response assessment after stereotactic body radiotherapy for spinal metastases: a report from the SPIne response assessment in neuro-oncology (SPINO) group. Lancet Oncol. 2015;16:e595–603.

    Article  PubMed  Google Scholar 

  • Tomeh AG, Mathis JM, Fenton DC, Levine AM, Belkogg SM. Biomechanical efficacy of unipediicular versus bipedicular vertebroplasty for the management of osteoporotic compression fractures. Spine. 1999;24:1772–6.

    Article  Google Scholar 

  • Virk MS, Han JE, Reiner AS, Mclaughlin LA, Sciubba DM, Lis E, Yamada Y, et al. Frequency of symptomatic vertebral body compression fractures requiring intervention following single-fraction stereotactic radiosurgery for spinal metastases. Neurosurg Focus. 2017;42(1):E8.

    Article  PubMed  Google Scholar 

  • Wang Z, Wang G, Yang H. Comparison of unilateral versus bilateral balloon kyphoplasty for the treatment of osteoporotic vertebral compression fractures. J Clin Neurosci. 2012;19(5):723–6.

    Article  PubMed  Google Scholar 

  • Weitao Y, Qiqing C, Songtao G, Jiaqiang W. Open vertebroplasty in the treatment of spinal metastatic disease. Clin Neurol Neurosurg. 2012;114:307–12.

    Article  PubMed  Google Scholar 

  • Wenger M, Markwalder TM. Surgically controlled, transpedicular methyl methacrylate vertebroplasty with fluoroscopic guidance. Acta Neurochir. 1999;41:625–31.

    Article  Google Scholar 

  • Wise JJ, Fischgrand JS, Herkowitz HN, et al. Complication, survival rates and risk factors of surgery for metastatic disease of the spine. Spine. 1999;24:1943–51.

    Article  CAS  PubMed  Google Scholar 

  • Yamada Y, Katsoulakis E, Laufer I, et al. The impact of histology and delivered dose on local control of spinal metastases treated with stereotactic radiosurgery. Neurosurg Focus. 2017;42:E6.

    Article  PubMed  PubMed Central  Google Scholar 

  • Zuckerman SL, Laufer I, Sahgal A, Yamada YJ, Schmidt MH, Chou D, Shin JH, Kumar N, Sciubba DM. When less is more: the indications for MIS techniques and separation surgery in metastatic spine disease. Spine (Phila Pa 1976). 2016;20(Suppl 20):S246–53.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Stefano Telera .

Rights and permissions

Reprints and permissions

Copyright information

© 2021 The Author(s), under exclusive license to Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Telera, S., Raus, L., Pipola, V., De Iure, F., Gasbarrini, A. (2021). Open Kyphoplasty and its Role in “Separation Surgery”. In: Vertebral Body Augmentation, Vertebroplasty and Kyphoplasty in Spine Surgery. Springer, Cham. https://doi.org/10.1007/978-3-030-76555-2_12

Download citation

Publish with us

Policies and ethics