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Proteome and Membrane Channels

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Book cover Biosensors and Biochips

Part of the book series: Learning Materials in Biosciences ((LMB))

Abstract

In this chapter, you will learn about the methods for analyzing a proteome. After looking at the classical method of 2D electrophoresis, we will explore some concepts and challenges of protein microarrays and discuss different detection methods. Moreover, you will get an introduction to the patch-clamp method for studying the physiology of cells and its use in pharmacology.

You will be able to explain how protein chips work and their potential use in medical diagnostics. Furthermore, you will be able to describe how to assess efficacy and side effects of drugs by patch-clamping techniques.

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Notes

  1. 1.

     Human Ether-a-go-go Related Gene (hERG) encodes the Kv11.1 potassium channel, which is responsible for the repolarizing current in the cardiac action potential. The vast majority of drugs associated with acquired long QT syndrome are known to interact with the hERG potassium channel.

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Authors and Affiliations

  1. Institute of Electron Devices and Circuits; Faculty of Engineering, Computer Science and Psychology, Ulm University, Ulm, Germany

    Alberto Pasquarelli

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  1. Alberto Pasquarelli
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Pasquarelli, A. (2021). Proteome and Membrane Channels. In: Biosensors and Biochips. Learning Materials in Biosciences. Springer, Cham. https://doi.org/10.1007/978-3-030-76469-2_10

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