Abstract
Chronic kidney disease (CKD) is increasingly recognised as a public health problem. This chapter introduces how the definition for CKD was developed. Causes of CKD as known to date are discussed and include recent findings on the importance of acute kidney injury (AKI). The chapter covers key epidemiological concepts as applied to renal epidemiology including incidence, prevalence, screening and how routinely collected data may be of use.
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References
Hole B, Gilg J, Casula A, Methven S, Castledine C. UK renal registry 20th annual report: UK renal replacement therapy adult incidence in 2016. Nephron. 2018;139(suppl1):13–46.
MacNeill S, Ford D, Evans K, Medcalf. UK renal registry 20th annual report: UK renal replacement therapy adult prevalence in 2016. Nephron. 2018;139(suppl1):47–74.
Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group. KDIGO 2012 clinical practice guideline for evaluation and management of chronic kidney disease. Kidney Int. 2013;3(Suppl):1–150.
Levey AS, de Jong PE, Coresh J, El Nahas M, Astor BC, Matsushita K, et al. The definition, classification, and prognosis of chronic kidney disease: a KDIGO Controversies Conference report. Kidney Int. 2011;80(1):17–28.
Coresh J, Astor BC, Greene T, Eknoyan G, Levey AS. Prevalence of chronic kidney disease and decreased kidney function in the adult US population: Third National Health and Nutrition Examination Survey. Am J Kidney Dis. 2003;41(1):1–12.
Froissart M, Rossert J, Jacquot C, Paillard M, Houillier P. Predictive performance of the modification of diet in renal disease and Cockcroft-Gault equations for estimating renal function. J Am Soc Nephrol. 2005;16(3):763–73.
Matsushita K, Mahmoodi BK, Woodward M, Emberson JR, Jafar TH, Jee SH, et al. Comparison of risk prediction using the CKD-EPI equation and the MDRD study equation for estimated glomerular filtration rate. JAMA. 2012;307(18):1941–51.
Giles PD, Fitzmaurice DA. Formula estimation of glomerular filtration rate: have we gone wrong. BMJ. 2007;334(7605):1198–200.
Hallan SI, Coresh J, Astor BC, Asberg A, Powe NR, Romundstad S, et al. International comparison of the relationship of chronic kidney disease prevalence and ESRD risk. J Am Soc Nephrol. 2006;17(8):2275–84.
Group TEIS. Geographic, ethnic, age-related and temporal variation in the incidence of end-stage renal disease in Europe, Canada and the Asia-Pacific region, 1998–2002. Nephrol Dial Transplant. 2002;21(8):2178–83.
Landray MJ, Wheeler DC, Lip GY, Newman DJ, Blann AD, McGlynn FJ, Ball S, Townend JN, Baigent C. Prediction of ESRD and death among people with CKD: the chronic renal impairment in Birmingham (CRIB) prospective cohort study - American Journal of Kidney Diseases (ajkd.org). Am J Kidney Dis. 2004;43(2):244–53.
Xue JL, Daniels F, Star RA, Kimmel PL, Eggers PW, Molitoris BA, Himmelfarb J, Collins AJ. Incidence and mortality of acute renal failure in Medicare beneficiaries, 1992 to 2001. J Am Soc Nephrol. 2006;17(4):1135–42.
Prescott GJ, Metcalfe W, Baharani J, Khan IH, Simpson K, Smith WC, MacLeod AM. A prospective national study of acute renal failure treated with RRT: incidence, aetiology and outcomes. Nephrol Dial Transplant. 2007;22(9):2513–9.
Coca SG, Yusuf B, Shlipak MG, Garg AX, Parikh CR. Long-term risk of mortality and other adverse outcomes after acute kidney injury: a systematic review and meta-analysis. Am J Kidney Dis. 2009;53(6):961–73. https://doi.org/10.1053/j.ajkd.2008.11.034.
Gale DP, de Jorge EG, Cook HT, Martinez-Barricarte R, Hadjisavvas A, et al. Identification of a mutation in complement factor H-related protein 5 in patients of Cypriot origin with glomerulonephritis. Lancet. 2010;376(9743):794–801.
Gonzalez-Quiroz M, Pearce N, Caplin B, Nitsch D. What do epidemiological studies tell us about chronic kidney disease of undetermined cause in Meso-America? A systematic review and meta-analysis. Clin Kidney J. 2018;11(4):496–506.
Caplin B, Jakobsson K, Glaser J, Nitsch D, Jha V, Singh A, Correa-Rotter R, Pearce N. International collaboration for the epidemiology of eGFR in low and middle income populations – rationale and core protocol for the disadvantaged populations eGFR epidemiology study (DEGREE). BMC Nephrol. 2017;18(1):1.
Luyckx VA, Brenner BM, Luyckx VA, Brenner BM. Birth weight, malnutrition and kidney-associated outcomes—a global concern. Nat Rev Nephrol. 2015;11:135–49.
Silverwood RJ, Pierce M, Hardy R, Sattar N, Whincup P, Ferro C, Savage C, Kuh D, Nitsch D. Low birth weight, later renal function, and the roles of adulthood blood pressure, diabetes, and obesity in a British birth cohort. Kidney Int. 2013;84(6):1262–70. https://doi.org/10.1038/ki.2013.223.
The SPRINT Research Group. A randomized trial of intensive versus standard blood-pressure control. New Engl J Med. 2015;373:2103–16.
Black C, Sharma P, Scotland G, McCullough K, et al. Early referral strategies for management of people with markers of renal disease: a systematic review of evidence of clinical effectiveness, cost-effectiveness and economic analysis. Health Technol Assess. 2010;14(21):1–184.
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Abro, A., Greenhall, G.H.B., Nitsch, D. (2022). Chronic Kidney Disease: Epidemiology and Causes. In: Harber, M. (eds) Primer on Nephrology. Springer, Cham. https://doi.org/10.1007/978-3-030-76419-7_65
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DOI: https://doi.org/10.1007/978-3-030-76419-7_65
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