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Non-collagenous ECM Matrix Components Growth Factors and Cytokines Involved in Matrix Mineralization

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Extracellular Matrix Biomineralization of Dental Tissue Structures

Part of the book series: Biology of Extracellular Matrix ((BEM,volume 10))

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Abstract

Biomineralization is a widespread process in living organisms to form minerals to harden tissues via hierarchically structured organic−inorganic composites. These processes are very diverse and complex. However, the site-specific location, size, and morphology of the crystals formed are specifically controlled by various cellular activities that vary between organisms. In vertebrates, bone, cartilage, and teeth are calcified tissues that are essential for the functional and structural integrity of the organism. The composition, crystal morphology, and materials properties of these structural elements are intriguing to multidisciplinary scientists. Further, the simplicity of biomineralization process with low energy costs, high quality, and formation under ambient conditions are impossible to reproduce in a bio-free system. Studies have implicated that the organic component of the mineralized tissues which include collagen and non-collagenous proteins (NCPs) play a critical role in mineral nucleation and growth. In this review, we highlight recent developments in dentin biomineralization process with respect to matrix proteins and growth factors.

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Acknowledgements

We are pleased to acknowledge the support from the National Institutes of Health. A.G has been supported by Grants DE011657, DE 028531and the Brodie Endowment Fund; A.M has been supported by NIDCR F30 DE027601: E.G by NIDCR F30 DE028193.

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  1. Annette Merkel and Elizabeth Guirado contributed equally with all other contributors.

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  1. Brodie Tooth Development Genetics & Regenerative Medicine Research Laboratory, Department of Oral Biology, University of Illinois at Chicago, Chicago, IL, USA

    Annette Merkel, Elizabeth Guirado, Karthikeyan Narayanan, Amudha Ganapathy & Anne George

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  1. Faculty of Fundamental and Biomedical Sciences, Paris Cite University INSERM UMR-S 1124, Paris, France

    Michel Goldberg

  2. Department of Orofacial Sciences, UCSF School of Dentistry, University of California, San Francisco, USA

    Pamela Den Besten

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Merkel, A., Guirado, E., Narayanan, K., Ganapathy, A., George, A. (2021). Non-collagenous ECM Matrix Components Growth Factors and Cytokines Involved in Matrix Mineralization. In: Goldberg, M., Den Besten, P. (eds) Extracellular Matrix Biomineralization of Dental Tissue Structures. Biology of Extracellular Matrix, vol 10. Springer, Cham. https://doi.org/10.1007/978-3-030-76283-4_4

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