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The Effects of Aging on the Hair Follicle

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Androgenetic Alopecia From A to Z

Abstract

As humans grow older, signs of aging become evident in all the organs of the human body. The first visible signs of aging appear on the skin. The aging skin changes due to a combination of endogenous factors (gene mutations, cellular metabolism, hormonal environment) and exogenous ones (chemicals, toxins, pollutants, UV radiation, smoking, diet, lifestyle). Sun-exposed skin areas will be mostly affected by exogenous factors, presenting as “extrinsic aging”. In contrast, typical changes resulting from endogenous factors are most visible in sun-protected areas and are primarily attributed to individual genetic and epigenetic mechanisms with interindividual variation. This process is coined “intrinsic aging”.

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Anastassakis, K. (2022). The Effects of Aging on the Hair Follicle. In: Androgenetic Alopecia From A to Z . Springer, Cham. https://doi.org/10.1007/978-3-030-76111-0_8

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