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Fastigial Nucleus Input/Output Related to Motor Control

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Cerebellum as a CNS Hub

Part of the book series: Contemporary Clinical Neuroscience ((CCNE))

Abstract

The cerebellar cortex is morphologically homogenous but can be separated into compartments based on distinct input/output patterns. Therefore, the function of each cerebellar compartment can be determined by the precise pattern of its unique afferent and efferent connections with extracerebellar CNS. Oscarsson proposed a microzonal structure of the cerebellar cortex as a structural–functional unit, and Ito extended this idea to a “corticonuclear microcomplex”: a structural–functional unit organization of the cerebellum. To clarify how the input/output structure gives rise to its separation into microcomplexes, we will first present the axonal trajectories of single mossy and climbing fiber neurons and the relationship of the A–D longitudinal zones with aldolase C longitudinal compartments in the cerebellar cortex and nuclei. Secondly, we will summarize neural circuits of inputs and outputs of the fastigial nucleus in relation to motor control and will discuss outstanding problems in our understanding of the cerebellar circuit.

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Acknowledgments

We thank R. Veale for valuable comments in improving the manuscript. This study was supported by JSPS KAKENHI Grant Number JP19K06937 to MT, Grants-in-Aid for Promotion of Scientific Research from the Naito Foundation to MT and from Brain Science Foundation to MT.

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  1. Department of Systems Neurophysiology, Tokyo Medical and Dental University, Graduate School of Medicine, Tokyo, Japan

    Mayu Takahashi & Yoshikazu Shinoda

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  1. Mayu Takahashi
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Correspondence to Mayu Takahashi .

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  1. Neurology, NCNP Hospital, National Center of Neurology and Psychiatry (NCNP), Kodaira, Tokyo, Japan

    Hidehiro Mizusawa

  2. Department of Anatomy and Physiology Faculty of Life Sciences, Jissen Women’s University, Tokyo, Japan

    Shinji Kakei

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Takahashi, M., Shinoda, Y. (2021). Fastigial Nucleus Input/Output Related to Motor Control. In: Mizusawa, H., Kakei, S. (eds) Cerebellum as a CNS Hub. Contemporary Clinical Neuroscience. Springer, Cham. https://doi.org/10.1007/978-3-030-75817-2_10

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