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Prolotherapy

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Regenerative Medicine

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Abstract

Regenerative medicine, though has recently become an increasingly researched field, has been around for many years, predominantly in the form of prolotherapy. The proposed mechanism of action of prolotherapy is to introduce a local irritant in order to cause cell death, thereby promoting the release of various growth factors. Prolotherapy is most commonly used for chronic musculoskeletal conditions, typically with tendinoses, ligamentous sprains, or articular cartilage damage, as in knee osteoarthritis. Furthermore, prolotherapy injections are commonly thought to be safe procedures with relatively few contraindications and thus pose to be a viable nonsurgical treatment option.

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Authors and Affiliations

  1. David Geffen School of Medicine—UCLA, Department of Physical Medicine and Rehabilitation, Los Angeles, CA, USA

    Jason Kajbaf

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  1. Jason Kajbaf
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Editors and Affiliations

  1. Ainsworth Institute of Pain Management, Mount Sinai Hospital Ainsworth Institute of Pain Management, New York, NY, USA

    Corey W Hunter

  2. Source Healthcare and Source Surgery Center, Santa Monica, CA, USA

    Timothy T. Davis

  3. Virginia iSpine Physicians, Richmond, VA, USA

    Michael J. DePalma

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Kajbaf, J. (2023). Prolotherapy. In: Hunter, C.W., Davis, T.T., DePalma, M.J. (eds) Regenerative Medicine . Springer, Cham. https://doi.org/10.1007/978-3-030-75517-1_2

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