Skip to main content

Vascular Tumors of the Breast

  • Chapter
  • First Online:
Mesenchymal Tumors of the Breast and Their Mimics
  • 277 Accesses

Abstract

While any type of vascular tumor can present in the breast, this chapter will focus on vascular tumors that more typically present in the breast. For example, there is a wide range of cutaneous hemangiomas, any of which could present in the skin of the breast, these entities will not be discussed in this chapter. The first half of the chapter will deal with benign vascular tumors, followed by a discussion of radiation and lymphedema-associated vascular tumors and finally primary angiosarcoma of the breast.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Selected References

  1. Adwani A, Bees N, Arnaout A, Lanaspre E. Hemangioma of the breast: clinical, mammographic, and ultrasound features. Breast J. 2006;12(3):271.

    Article  Google Scholar 

  2. Aydın OU, Soylu L, Ercan Aİ, Bilezikçi B, Özbaş S. Cavernous hemangioma in the breast. J Breast Health. 2015;11(4):199–201.

    Article  Google Scholar 

  3. Baker GM, Schnitt SJ. Vascular lesions of the breast. Semin Diagn Pathol. 2017;34(5):410–9.

    Article  Google Scholar 

  4. Billings SD, McKenney JK, Folpe AL, Hardacre MC, Weiss SW. Cutaneous angiosarcoma following breast-conserving surgery and radiation: an analysis of 27 cases. Am J Surg Pathol. 2004;28(6):781–8.

    Article  Google Scholar 

  5. Branton PA, Lininger R, Tavassoli FA. Papillary endothelial hyperplasia of the breast: the great impostor for angiosarcoma: a clinicopathologic review of 17 cases. Int J Surg Pathol. 2003;11(2):83–7.

    Article  Google Scholar 

  6. Brenn T, Fletcher CD. Radiation-associated cutaneous atypical vascular lesions and angiosarcoma: clinicopathologic analysis of 42 cases. Am J Surg Pathol. 2005;29(8):983–96.

    Article  Google Scholar 

  7. Brodie C, Provenzano E. Vascular proliferations of the breast. Histopathology. 2008;52(1):30–44.

    Article  CAS  Google Scholar 

  8. Chulakadabba A, Denariyakoon S, Chakkabat P, et al. Preoperative radiation in large angiomatosis of the breast, attempting breast conserving surgery: multidisciplinary approach. J Surg Case Rep. 2018;2018(2):rjy024.

    Article  CAS  Google Scholar 

  9. Cui L, Zhang J, Zhang X, et al. Angiosarcoma (Stewart-Treves syndrome) in postmastectomy patients: report of 10 cases and review of literature. Int J Clin Exp Pathol. 2015;8(9):11108–15.

    CAS  PubMed  PubMed Central  Google Scholar 

  10. Daniels BH, Ko JS, Rowe JJ, Downs-Kelly E, Billings SD. Radiation-associated angiosarcoma in the setting of breast cancer mimicking radiation dermatitis: a diagnostic pitfall. J Cutan Pathol. 2017;44(5):456–61.

    Article  Google Scholar 

  11. de Mello Tucunduva TC, Gaziero A, Tostes VS, et al. Cavernous hemangioma between the elastomer and fibrous capsule of a breast implant. Aesthet Plast Surg. 2018;42(5):1257–60.

    Article  Google Scholar 

  12. Di Tommaso L, Rosai J. The capillary lobule: a deceptively benign feature of post-radiation angiosarcoma of the skin: report of three cases. Am J Dermatopathol. 2005;27(4):301–5.

    Article  Google Scholar 

  13. Diaz-Cascajo C, Borghi S, Weyers W, Retzlaff H, Requena L, Metze D. Benign lymphangiomatous papules of the skin following radiotherapy: a report of five new cases and review of the literature. Histopathology. 1999;35(4):319–27.

    Article  CAS  Google Scholar 

  14. Donnell RM, Rosen PP, Lieberman PH, et al. Angiosarcoma and other vascular tumors of the breast. Am J Surg Pathol. 1981;5(7):629–42.

    Article  CAS  Google Scholar 

  15. Fernandez AP, Sun Y, Tubbs RR, Goldblum JR, Billings SD. FISH for MYC amplification and anti-MYC immunohistochemistry: useful diagnostic tools in the assessment of secondary angiosarcoma and atypical vascular proliferations. J Cutan Pathol. 2012;39(2):234–42.

    Article  Google Scholar 

  16. Fineberg S, Rosen PP. Cutaneous angiosarcoma and atypical vascular lesions of the skin and breast after radiation therapy for breast carcinoma. Am J Clin Pathol. 1994;102(6):757–63.

    Article  CAS  Google Scholar 

  17. Fraga-Guedes C, Gobbi H, Mastropasqua MG, et al. Clinicopathological and immunohistochemical study of 30 cases of post-radiation atypical vascular lesion of the breast. Breast Cancer Res Treat. 2014;146(2):347–54.

    Article  CAS  Google Scholar 

  18. Ginter PS, McIntire PJ, Irshaid L, Liu YF, Shin SJ. Angiomatosis of the breast: a clinicopathological and immunophenotypical characterisation of seven cases. J Clin Pathol. 2019;72(9):597–602.

    Article  Google Scholar 

  19. Guilbert MC, Frost EP, Brock JE, Lester SC. Distinguishing papillary endothelial hyperplasia and angiosarcoma on core needle biopsy of the breast: the importance of clinical and radiologic correlation. Breast J. 2018;24(4):487–92.

    Article  CAS  Google Scholar 

  20. Hoda SA, Cranor ML, Rosen PP. Hemangiomas of the breast with atypical histological features. Further analysis of histological subtypes confirming their benign character. Am J Surg Pathol. 1992;16(6):553–60.

    Article  CAS  Google Scholar 

  21. Jesinger RA, Lattin GE Jr, Ballard EA, Zelasko SM, Glassman LM. Vascular abnormalities of the breast: arterial and venous disorders, vascular masses, and mimic lesions with radiologic-pathologic correlation. Radiographics. 2011;31(7):E117–36.

    Article  Google Scholar 

  22. Jozefczyk MA, Rosen PP. Vascular tumors of the breast. II. Perilobular hemangiomas and hemangiomas. Am J Surg Pathol. 1985;9(7):491–503.

    Article  CAS  Google Scholar 

  23. Lesueur GC, Brown RW, Bhathal PS. Incidence of perilobular hemangioma in the female breast. Arch Pathol Lab Med. 1983;107(6):308–10.

    CAS  PubMed  Google Scholar 

  24. Lorente-Ramos RM, Azpeitia Armán J, Martínez Izquierdo MA, Pérez QA. Papillary endothelial hyperplasia (Masson's tumor) developed in the capsule of the implant in a breast cancer patient treated with mastectomy and radiation therapy. J Clin Ultrasound. 2020;48(4):222–6.

    Article  Google Scholar 

  25. Ma W, Jin F, Wu Y. Capillary hemangioma of the breast-a rare type of benign breast tumor. Breast J. 2016;22(3):355–6.

    Article  Google Scholar 

  26. Mantilla JG, Koenigsberg T, Reig B, Shapiro N, Villanueva-Siles E, Fineberg S. Core biopsy of vascular neoplasms of the breast: pathologic features, imaging, and clinical findings. Am J Surg Pathol. 2016;40(10):1424–34.

    Article  Google Scholar 

  27. Mentzel T, Schildhaus HU, Palmedo G, Büttner R, Kutzner H. Postradiation cutaneous angiosarcoma after treatment of breast carcinoma is characterized by MYC amplification in contrast to atypical vascular lesions after radiotherapy and control cases: clinicopathological, immunohistochemical and molecular analysis of 66 cases. Mod Pathol. 2012;25(1):75–85.

    Article  CAS  Google Scholar 

  28. Nascimento AF, Raut CP, Fletcher CD. Primary angiosarcoma of the breast: clinicopathologic analysis of 49 cases, suggesting that grade is not prognostic. Am J Surg Pathol. 2008;32(12):1896–904.

    Article  Google Scholar 

  29. Patton KT, Deyrup AT, Weiss SW. Atypical vascular lesions after surgery and radiation of the breast: a clinicopathologic study of 32 cases analyzing histologic heterogeneity and association with angiosarcoma. Am J Surg Pathol. 2008;32(6):943–50.

    Article  Google Scholar 

  30. Rosen PP, Jozefczyk MA, Boram LH. Vascular tumors of the breast. IV. The venous hemangioma. Am J Surg Pathol. 1985;9(9):659–65.

    Article  CAS  Google Scholar 

  31. Rosen PP, Kimmel M, Ernsberger D. Mammary angiosarcoma. The prognostic significance of tumor differentiation. Cancer. 1988;62(10):2145–51.

    Article  CAS  Google Scholar 

  32. Rosen PP, Ridolfi RL. The perilobular hemangioma. A benign microscopic vascular lesion of the breast. Am J Clin Pathol. 1977;68(1):21–3.

    Article  CAS  Google Scholar 

  33. Rosen PP. Vascular tumors of the breast. III Angiomatosis. Am J Surg Pathol. 1985;9(9):652–8.

    Article  CAS  Google Scholar 

  34. Shin SJ, Lesser M, Rosen PP. Hemangiomas and angiosarcomas of the breast: diagnostic utility of cell cycle markers with emphasis on Ki-67. Arch Pathol Lab Med. 2007;131(4):538–44.

    Article  Google Scholar 

  35. Stewart FW, Treves N. Lymphangiosarcoma in postmastectomy lymphedema; a report of six cases in elephantiasis chirurgica. Cancer. 1948;1(1):64–81.

    Article  CAS  Google Scholar 

  36. Tilve A, Mallo R, Pérez A, Santiago P. Breast hemangiomas: correlation between imaging and pathologic findings. J Clin Ultrasound. 2012;40(8):512–7.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Steven D. Billings .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2021 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Billings, S.D. (2021). Vascular Tumors of the Breast. In: Rowe, J.J., Downs-Kelly, E. (eds) Mesenchymal Tumors of the Breast and Their Mimics. Springer, Cham. https://doi.org/10.1007/978-3-030-74474-8_4

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-74474-8_4

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-74473-1

  • Online ISBN: 978-3-030-74474-8

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics