Skip to main content

Spices as Traditional Remedies: Scientifically Proven Benefits

  • Chapter
  • First Online:
Rationality and Scientific Lifestyle for Health

Abstract

Spices have been added to foods for centuries as flavors, preservatives, and colors and have also been used in traditional medicine in various countries to treat many diseases. Spices play an important role in human health and can be considered as the first functional foods. Although the amount of spices consumed is very low compared to many other foods, the role of spices in the daily diet should not be underestimated due to their health properties. Saffron, ginger, cinnamon, and turmeric are four globally common spices that have been widely used owing to well-known medical benefits in different traditional medicine systems, including Ayurveda, traditional Chinese, and Persian medicine since ancient times. Some general or specific health benefits of these spices include anti-inflammatory, antioxidant, antimicrobial, anti-diabetic, and antihypertensive activities, which have potential protective properties against some ailments such as cancer, type 2 diabetes, neurodegenerative and cardiovascular diseases. Recent scientific studies on the therapeutic properties of these common spices have been reviewed in this chapter.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 34.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 44.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 44.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Akaberi M, Boghrati Z, Amiri MS, Emami SA (2019) Saffron: the golden spice. In: Science of spices and culinary herbs-latest laboratory, pre-clinical, and clinical studies, vol 1, pp 1–29

    Google Scholar 

  • Alavi F, Emam-Djomeh Z, Yarmand MS, Salami M, Momen S, Moosavi-Movahedi AA (2018) Cold gelation of curcumin loaded whey protein aggregates mixed with K-carrageenan: impact of gel microstructure on the gastrointestinal fate of curcumin. Food Hydrocolloids 85:267–280

    Article  Google Scholar 

  • Alsherbiny MA, Abd-Elsalam WH, Taher E, Fares M, Torres A, Chang D, Li CG (2019) Ameliorative and protective effects of ginger and its main constituents against natural, chemical and radiation-induced toxicities: a comprehensive review. Food Chem Toxicol 123:72–97

    Article  PubMed  Google Scholar 

  • Arablou T, Aryaeian N (2018) The effect of ginger (Zingiber officinale) as an ancient medicinal plant on improving blood lipids. J Herbal Med 12:11–15

    Article  Google Scholar 

  • Arun N, Nalini N (2002) Efficacy of turmeric on blood sugar and polyol pathway in diabetic albino rats. Plant Foods Hum Nutr 57(1):41–52

    Article  PubMed  Google Scholar 

  • Asadollahi M, Nikdokht P, Hatef B, Sadr SS, Sahraei H, Assarzadegan F, Jahromi GP (2019) Protective properties of the aqueous extract of saffron (Crocus sativus L.) in ischemic stroke, randomized clinical trial. J Ethnopharmacol 238:111833

    Google Scholar 

  • Barceloux DG (2008) Medical toxicology of natural substances: foods, fungi, medicinal herbs, plants, and venomous animals. Wiley

    Google Scholar 

  • Begas E, Bounitsi M, Kilindris T, Kouvaras E, Makaritsis K, Kouretas D, Asprodini EK (2019) Effects of short-term saffron (Crocus sativus L.) intake on the in vivo activities of xenobiotic metabolizing enzymes in healthy volunteers. Food Chem Toxicol 130:32–43

    Article  PubMed  Google Scholar 

  • Bi X, Lim J, Henry CJ (2017) Spices in the management of diabetes mellitus. Food Chem 217:281–293

    Article  PubMed  Google Scholar 

  • Boskabady MH, Gholamnezhad Z, Ghorani V, Saadat S (2019) The effect of crocus sativus (saffron) on the respiratory system: traditional and experimental evidence. In: Science of spices and culinary herbs-latest laboratory, pre-clinical, and clinical studies, vol 1, pp 30–54

    Google Scholar 

  • Bukhari SI, Manzoor M, Dhar M (2018) A comprehensive review of the pharmacological potential of Crocus sativus and its bioactive apocarotenoids. Biomed Pharmacother 98:733–745

    Article  PubMed  Google Scholar 

  • Cheng DM, Kuhn P, Poulev A, Rojo LE, Lila MA, Raskin I (2012) In vivo and in vitro antidiabetic effects of aqueous cinnamon extract and cinnamon polyphenol-enhanced food matrix. Food Chem 135(4):2994–3002

    Article  PubMed  PubMed Central  Google Scholar 

  • Choi JW, Park H-Y, Oh MS, Yoo HH, Lee S-H, Ha SK (2017) Neuroprotective effect of 6-paradol enriched ginger extract by fermentation using schizosaccharomyces pombe. J Funct Foods 31:304–310

    Article  Google Scholar 

  • Choi JG, Kim SY, Jeong M, Oh MS (2018) Pharmacotherapeutic potential of ginger and its compounds in age-related neurological disorders. Pharmacol Ther 182:56–69

    Article  PubMed  Google Scholar 

  • Davis PA, Yokoyama W (2011) Cinnamon intake lowers fasting blood glucose: meta-analysis. J Med Food 14(9):884–889

    Article  PubMed  Google Scholar 

  • De AK, De M (2019) Functional and therapeutic applications of some important spices. In: The role of functional food security in global health. Elsevier, pp 499–510

    Google Scholar 

  • El-Sayed SM, Youssef AM (2019) Potential application of herbs and spices and their effects in functional dairy products. Heliyon 5(6):e01989

    Article  PubMed  PubMed Central  Google Scholar 

  • Garavand F, Rahaee S, Vahedikia N, Jafari SM (2019) Different techniques for extraction and micro/nanoencapsulation of saffron bioactive ingredients. Trends Food Sci Technol 89:26–44

    Article  Google Scholar 

  • Ghadrdoost B, Vafaei AA, Rashidy-Pour A, Hajisoltani R, Bandegi AR, Motamedi F, Haghighi S, Sameni HR, Pahlvan S (2011) Protective effects of saffron extract and its active constituent crocin against oxidative stress and spatial learning and memory deficits induced by chronic stress in rats. Eur J Pharmacol 667(1–3):222–229

    Article  PubMed  Google Scholar 

  • Ghaffari S, Roshanravan N (2019) Saffron; an updated review on biological properties with special focus on cardiovascular effects. Biomed Pharmacother 109:21–27

    Article  PubMed  Google Scholar 

  • Ghanbari J, Khajoei-Nejad G, van Ruth SM, Aghighi S (2019) The possibility for improvement of flowering, corm properties, bioactive compounds, and antioxidant activity in saffron (Crocus sativus L.) by different nutritional regimes. Ind Crops Prod 135:301–310

    Article  Google Scholar 

  • Hadi A, Pourmasoumi M, Ghaedi E, Sahebkar A (2019) The effect of curcumin/turmeric on blood pressure modulation: a systematic review and meta-analysis. Pharmacol Res 104505

    Google Scholar 

  • Ho S-C, Chang K-S, Chang P-W (2013b) Inhibition of neuroinflammation by cinnamon and its main components. Food Chem 138(4):2275–2282

    Article  PubMed  Google Scholar 

  • Ho S-C, Chang K-S, Lin C-C (2013a) Anti-neuroinflammatory capacity of fresh ginger is attributed mainly to 10-gingerol. Food Chem 141(3):3183–3191

    Article  PubMed  Google Scholar 

  • Hosseini SI, Farrokhi N, Shokri K, Khani MR, Shokri B (2018) Cold low pressure O2 plasma treatment of Crocus sativus: an efficient way to eliminate toxicogenic fungi with minor effect on molecular and cellular properties of saffron. Food Chem 257:310–315

    Article  PubMed  Google Scholar 

  • Hsiang C-Y, Lo H-Y, Huang H-C, Li C-C, Wu S-L, Ho T-Y (2013) Ginger extract and zingerone ameliorated trinitrobenzene sulphonic acid-induced colitis in mice via modulation of nuclear factor-κb activity and interleukin-1β signalling pathway. Food Chem 136(1):170–177

    Article  PubMed  Google Scholar 

  • Hu Y, Zhang J, Kong W, Zhao G, Yang M (2017) Mechanisms of antifungal and anti-aflatoxigenic properties of essential oil derived from turmeric (Curcuma longa L.) on aspergillus flavus. Food Chem 220:1–8

    Article  PubMed  Google Scholar 

  • Huang Z, Jia S, Zhang L, Liu X, Luo Y (2019) Inhibitory effects and membrane damage caused to fish spoilage bacteria by cinnamon bark (Cinnamomum tamala) oil. LWT 112:108195

    Article  Google Scholar 

  • Jafarzadeh A, Nemati M (2018) Therapeutic potentials of ginger for treatment of multiple sclerosis: a review with emphasis on its immunomodulatory, anti-inflammatory and anti-oxidative properties. J Neuroimmunol 324:54–75

    Article  PubMed  Google Scholar 

  • Jayaprakasha G, Rao LJM (2011) Chemistry, biogenesis, and biological activities of Cinnamomum zeylanicum. Crit Rev Food Sci Nutr 51(6):547–562

    Article  PubMed  Google Scholar 

  • Kang C, Lee H, Jung E-S, Seyedian R, Jo M, Kim J, Kim J-S, Kim E (2012) Saffron (Crocus sativus L.) increases glucose uptake and insulin sensitivity in muscle cells via multipathway mechanisms. Food Chem 135(4):2350–2358

    Google Scholar 

  • Karimi-Nazari E, Nadjarzadeh A, Masoumi R, Marzban A, Mohajeri SA, Ramezani-Jolfaie N, Salehi-Abargouei A (2019) Effect of saffron (Crocus sativus L.) on lipid profile, glycemic indices and antioxidant status among overweight/obese prediabetic individuals: a double-blinded randomized controlled trial. Clin Nutr ESPEN 34:130–136

    Article  PubMed  Google Scholar 

  • Kawatra P, Rajagopalan R (2015) Cinnamon: mystic powers of a minute ingredient. Pharmacognosy Res 7(Suppl 1):S1

    Article  PubMed  PubMed Central  Google Scholar 

  • Khorvash F, Askari G, Zarei A (2019) The effect of cinnamon on migraine treatment and blood levels of Cgrp and Il-6: a double-blinded randomized controlled clinical trial. J Neurol Sci 405:106–107

    Google Scholar 

  • Kim J-I, Lee J-H, Song Y, Kim Y-T, Lee Y-H, Kang H (2018) Oral consumption of cinnamon enhances the expression of immunity and lipid absorption genes in the small intestinal epithelium and alters the gut microbiota in normal mice. J Funct Foods 49:96–104

    Article  Google Scholar 

  • Komolafe O, Arayombo B, Abiodun A, Saka O, Abijo A, Ojo S, Fakunle O (2020) Immunohistochemical and histological evaluations of cyclophosphamide-induced acute cardiotoxicity in wistar rats: the role of turmeric extract (Curcuma). Morphologie

    Google Scholar 

  • Kota N, Panpatil VV, Kaleb R, Varanasi B, Polasa K (2012) Dose-dependent effect in the inhibition of oxidative stress and anticlastogenic potential of ginger in Stz induced diabetic rats. Food Chem 135(4):2954–2959

    Article  PubMed  Google Scholar 

  • Krüger S, Bergin A, Morlock G (2018) Effect-directed analysis of ginger (Zingiber officinale) and its food products, and quantification of bioactive compounds via high-performance thin-layer chromatography and mass spectrometry. Food Chem 243:258–268

    Article  PubMed  Google Scholar 

  • Lee J, Jun W (2009) Methanolic extract of turmeric (Curcuma longa L.) enhanced the lipolysis by up-regulation of lipase MRNA expression in differentiated 3t3-L1 adipocytes. Food Sci Biotechnol 18(6):1500–1504

    Google Scholar 

  • Lekshmi P, Arimboor R, Indulekha P, Nirmala Menon A (2012) Turmeric (Curcuma longa L.) volatile oil inhibits key enzymes linked to type 2 diabetes. Int J Food Sci Nutr 63(7):832–834

    Google Scholar 

  • Li M, Yue GG-L, Tsui SK-W, Fung K-P, Bik-San Lau C (2018) Turmeric extract, with absorbable curcumin, has potent anti-metastatic effect in vitro and in vivo. Phytomedicine 46:131–141

    Article  PubMed  Google Scholar 

  • Li A-L, Li G-H, Li Y-R, Wu X-Y, Ren D-M, Lou H-X, Wang X-N, Shen T (2019b) Lignan and flavonoid support the prevention of cinnamon against oxidative stress related diseases. Phytomedicine 53:143–153

    Article  PubMed  Google Scholar 

  • Li H, Liu Y, Luo D, Ma Y, Zhang J, Li M, Yao L, Shi X, Liu X, Yang K (2019) Ginger for health care: an overview of systematic reviews. Complement Therapies Med

    Google Scholar 

  • Lim S-T, Han J-A (2016) Improvement in antioxidant functionality and shelf life of Yukwa (fried rice snack) by turmeric (Curcuma longa L.) powder addition. Food Chem 199:590–596

    Article  PubMed  Google Scholar 

  • Linardaki ZI, Orkoula MG, Kokkosis AG, Lamari FN, Margarity M (2013) Investigation of the neuroprotective action of saffron (Crocus sativus L.) in aluminum-exposed adult mice through behavioral and neurobiochemical assessment. Food Chem Toxicol 52:163–170

    Article  PubMed  Google Scholar 

  • Ling J, Wei B, Lv G, Ji H, Li S (2012) Anti-hyperlipidaemic and antioxidant effects of turmeric oil in hyperlipidaemic rats. Food Chem 130(2):229–235

    Article  Google Scholar 

  • Lopes BP, Gaique TG, Souza LL, Paula GSM, Kluck GE, Atella GC, Pazos-Moura CC, Oliveira KJ (2018) Beneficial effects of cinnamon on hepatic lipid metabolism are impaired in hypothyroid rats. J Funct Foods 50:210–215

    Article  Google Scholar 

  • Lopresti AL, Drummond PD (2017) Efficacy of curcumin, and a saffron/curcumin combination for the treatment of major depression: a randomised, double-blind, placebo-controlled study. J Affect Disord 207:188–196

    Article  PubMed  Google Scholar 

  • Lopresti AL, Drummond PD, Inarejos-García AM, Prodanov M (2018) Affron®, a standardised extract from saffron (Crocus sativus L.) for the treatment of youth anxiety and depressive symptoms: a randomised, double-blind placebo-controlled study. J Affect Disord 232:349–357

    Article  PubMed  Google Scholar 

  • Lv J, Huang H, Yu L, Whent M, Niu Y, Shi H, Wang TT, Luthria D, Charles D, Yu LL (2012) Phenolic composition and nutraceutical properties of organic and conventional cinnamon and peppermint. Food Chem 132(3):1442–1450

    Article  PubMed  Google Scholar 

  • Maharlouei N, Tabrizi R, Lankarani KB, Rezaianzadeh A, Akbari M, Kolahdooz F, Rahimi M, Keneshlou F, Asemi Z (2019) The effects of ginger intake on weight loss and metabolic profiles among overweight and obese subjects: a systematic review and meta-analysis of randomized controlled trials. Crit Rev Food Sci Nutr 59(11):1753–1766

    Article  PubMed  Google Scholar 

  • Martin RC, Aiyer HS, Malik D, Li Y (2012) Effect on pro-inflammatory and antioxidant genes and bioavailable distribution of whole turmeric vs curcumin: similar root but different effects. Food Chem Toxicol 50(2):227–231

    Article  PubMed  Google Scholar 

  • Mashmoul M, Azlan A, Yusof BNM, Khaza’ai H, Mohtarrudin N, Boroushaki MT (2014) Effects of saffron extract and crocin on anthropometrical, nutritional and lipid profile parameters of rats fed a high fat diet. J Funct Foods 8:180–187

    Article  Google Scholar 

  • Melnyk JP, Wang S, Marcone MF (2010) Chemical and biological properties of the world’s most expensive spice: saffron. Food Res Int 43(8):1981–1989

    Article  Google Scholar 

  • Menghini L, Leporini L, Vecchiotti G, Locatelli M, Carradori S, Ferrante C, Zengin G, Recinella L, Chiavaroli A, Leone S (2018) Crocus sativus L. stigmas and by products: qualitative fingerprint, antioxidant potentials and enzyme inhibitory activities. Food Res Int 109:91–98

    Article  PubMed  Google Scholar 

  • Mohammadian M, Salami M, Momen S, Alavi F, Emam-Djomeh Z (2019) Fabrication of curcumin-loaded whey protein microgels: structural properties, antioxidant activity, and in vitro release behavior. LWT-Food Sci Technol 103:94–100

    Article  Google Scholar 

  • Moshiri M, Vahabzadeh M, Hosseinzadeh H (2015) Clinical applications of saffron (Crocus sativus) and its constituents: a review. Drug Res 65(06):287–295

    Google Scholar 

  • Mousavi SM, Rahmani J, Kord-Varkaneh H, Sheikhi A, Larijani B, Esmaillzadeh A (2020) Cinnamon supplementation positively affects obesity: a systematic review and dose-response meta-analysis of randomized controlled trials. Clin Nutr 39(1):123–133

    Article  PubMed  Google Scholar 

  • Murthy PS, Gautam R (2015) Ginger oleoresin chemical composition, bioactivity and application as bio-preservatives. J Food Process Preserv 39(6):1905–1912

    Article  Google Scholar 

  • Najafabadi BT, Ghamari K, Ranjabari TK, Noorbala AA, Daryani NE, Vanaki E, Akhondzadeh S (2019) Therapeutic effects of saffron (Crocus sativus) versus fluoxetine on irritable bowel syndrome: a double-blind randomized clinical trial. Adv Integrat Med 6(4):167–173

    Article  Google Scholar 

  • Namazi N, Khodamoradi K, Khamechi SP, Heshmati J, Ayati MH, Larijani B (2019) The impact of cinnamon on anthropometric indices and glycemic status in patients with type 2 diabetes: a systematic review and meta-analysis of clinical trials. Complement Ther Med 43:92–101

    Article  PubMed  Google Scholar 

  • Oh S, Lee M-S, Jung S, Kim S, Park H, Park S, Kim S-Y, Kim C-T, Jo Y-H, Kim I-H (2017) Ginger extract increases muscle mitochondrial biogenesis and serum hdl-cholesterol level in high-fat diet-fed rats. J Funct Foods 29:193–200

    Article  Google Scholar 

  • Papandreou MA, Tsachaki M, Efthimiopoulos S, Cordopatis P, Lamari FN, Margarity M (2011) Memory enhancing effects of saffron in aged mice are correlated with antioxidant protection. Behav Brain Res 219(2):197–204

    Article  PubMed  Google Scholar 

  • Pourmasoumi M, Hadi A, Rafie N, Najafgholizadeh A, Mohammadi H, Rouhani MH (2018) The effect of ginger supplementation on lipid profile: a systematic review and meta-analysis of clinical trials. Phytomedicine 43:28–36

    Article  PubMed  Google Scholar 

  • Qin B, Panickar KS, Anderson RA (2010) Cinnamon: potential role in the prevention of insulin resistance, metabolic syndrome, and type 2 diabetes. J Diabetes Sci Technol 4(3):685–693

    Article  PubMed  PubMed Central  Google Scholar 

  • Rahiman N, Akaberi M, Sahebkar A, Emami SA, Tayarani-Najaran Z (2018) Protective effects of saffron and its active components against oxidative stress and apoptosis in endothelial cells. Microvasc Res 118:82–89

    Article  PubMed  Google Scholar 

  • Rezaee-Khorasany A, Razavi BM, Taghiabadi E, Yazdi AT, Hosseinzadeh H (2019) Effect of saffron (stigma of Crocus sativus L.) aqueous extract on ethanol toxicity in rats: a biochemical, histopathological and molecular study. J Ethnopharmacol 237:286–299

    Article  PubMed  Google Scholar 

  • Ribeiro-Santos R, Andrade M, Madella D, Martinazzo AP, Moura LdAG, de Melo NR, Sanches-Silva A (2017) Revisiting an ancient spice with medicinal purposes: cinnamon. Trends Food Sci Technol 62:154–169

    Article  Google Scholar 

  • Salehi E, Gavari N, Chehrei A, Amani S, Amani N, Zaghi K (2019) Efficient separation of triglyceride from blood serum using cinnamon as a novel biosorbent: adsorption thermodynamics, kinetics, isothermal and process optimization using response surface methodology. Process Biochem 77:122–136

    Article  Google Scholar 

  • Samarghandian S, Azimi-Nezhad M, Farkhondeh T (2017) Immunomodulatory and antioxidant effects of saffron aqueous extract (Crocus sativus L.) on streptozotocin-induced diabetes in rats. Indian Heart J 69 (2):151–159

    Google Scholar 

  • Santos HO, da Silva GA (2018) To what extent does cinnamon administration improve the glycemic and lipid profiles? Clin Nutr ESPEN 27:1–9

    Article  PubMed  Google Scholar 

  • Sarkar P, Thirumurugan K (2019) Modulatory functions of bioactive fruits, vegetables and spices in adipogenesis and angiogenesis. J Funct Foods 53:318–336

    Article  Google Scholar 

  • Selvi NMK, Sridhar M, Swaminathan R, Sripradha R (2015) Efficacy of turmeric as adjuvant therapy in type 2 diabetic patients. Indian J Clin Biochem 30(2):180–186

    Article  Google Scholar 

  • Shahi T, Assadpour E, Jafari SM (2016) Main chemical compounds and pharmacological activities of stigmas and tepals of ‘red gold’; saffron. Trends Food Sci Technol 58:69–78

    Article  Google Scholar 

  • Shahmansouri N, Farokhnia M, Abbasi S-H, Kassaian SE, Tafti A-AN, Gougol A, Yekehtaz H, Forghani S, Mahmoodian M, Saroukhani S (2014) A randomized, double-blind, clinical trial comparing the efficacy and safety of Crocus sativus L. with fluoxetine for improving mild to moderate depression in post percutaneous coronary intervention patients. J Affect Disord 155:216–222

    Article  PubMed  Google Scholar 

  • Shanmugam KR, Mallikarjuna K, Nishanth K, Kuo CH, Reddy KS (2011) Protective effect of dietary ginger on antioxidant enzymes and oxidative damage in experimental diabetic rat tissues. Food Chem 124(4):1436–1442

    Article  Google Scholar 

  • Singh DB, Maurya AK, Rai D (2019) Antibacterial and anticancer activities of turmeric and its active ingredient curcumin, and mechanism of action. In: Science of spices and culinary herbs-latest laboratory, pre-clinical, and clinical studies, vol 1, pp 74–103

    Google Scholar 

  • Srinivasan K (2019) Nutraceutical activities of turmeric (Curcuma longa) and its bioactive constituent curcumin. In: Science of spices and culinary herbs-latest laboratory, pre-clinical, and clinical studies, vol 1, pp 55–73

    Google Scholar 

  • Taghavi F, Poursasan N, Moosavi-Movahedi AA (2020) Ginger: natural pharmacy. University of Tehran Press

    Google Scholar 

  • Tang P-l, Hao E-w, Deng J-g, Hou X-t, Zhang Z-h, Xie J-l (2019) Boost anti-oxidant activity of yogurt with extract and hydrolysate of cinnamon residues. Chin Herbal Med 11(4):417–422

    Article  Google Scholar 

  • Thomas J, Kuruvilla K (2012) Cinnamon. In: Handbook of herbs and spices. Elsevier, pp 182–196

    Google Scholar 

  • Toma L, Raileanu M, Deleanu M, Stancu CS, Sima AV (2018) Novel molecular mechanisms by which ginger extract reduces the inflammatory stress in Tnfα-activated human endothelial cells; decrease of ninjurin-1, Tnfr1 and nadph oxidase subunits expression. J Funct Foods 48:654–664

    Article  Google Scholar 

  • Tóth B, Lantos T, Hegyi P, Viola R, Vasas A, Benkő R, Gyöngyi Z, Vincze Á, Csécsei P, Mikó A (2018) Ginger (Zingiber officinale): an alternative for the prevention of postoperative nausea and vomiting. A meta-analysis. Phytomedicine 50:8–18

    Article  PubMed  Google Scholar 

  • Tuberoso CI, Rosa A, Montoro P, Fenu MA, Pizza C (2016) Antioxidant activity, cytotoxic activity and metabolic profiling of juices obtained from saffron (Crocus sativus L.) floral by-products. Food Chem 199:18–27

    Article  PubMed  Google Scholar 

  • Vallianou N, Tsang C, Taghizadeh M, Davoodvandi A, Jafarnejad S (2019) Effect of cinnamon (Cinnamomum zeylanicum) supplementation on serum C-reactive protein concentrations: a meta-analysis and systematic review. Complement Ther Med 42:271–278

    Article  PubMed  Google Scholar 

  • Vázquez-Fresno R, Rosana ARR, Sajed T, Onookome-Okome T, Wishart NA, Wishart DS (2019) Herbs and spices-biomarkers of intake based on human intervention studies–a systematic review. Genes Nutr 14(1):18–45

    Article  PubMed  PubMed Central  Google Scholar 

  • Vipin A, Rao R, Kurrey NK, KA AA, Venkateswaran G (2017) Protective effects of phenolics rich extract of ginger against aflatoxin B1-induced oxidative stress and hepatotoxicity. Biomed Pharmacother 91:415–424

    Google Scholar 

  • White CM, Pasupuleti V, Roman YM, Li Y, Hernandez AV (2019) Oral turmeric/curcumin effects on inflammatory markers in chronic inflammatory diseases: a systematic review and meta-analysis of randomized controlled trials. Pharmacol Res 104280

    Google Scholar 

  • Yang C-Y, Cho M-J, Lee C-H (2011) Effects of fermented turmeric extracts on the obesity in rats fed a high-fat diet. J Animal Sci Technol 53(1):75–81

    Article  Google Scholar 

  • Zhang A, Shen Y, Cen M, Hong X, Shao Q, Chen Y, Zheng B (2019) Polysaccharide and crocin contents, and antioxidant activity of saffron from different origins. Ind Crops Prod 133:111–117

    Article  Google Scholar 

  • Zhou J-L, Zheng J-Y, Cheng X-Q, Xin G-Z, Wang S-L, Xie T (2019) Chemical markers’ knockout coupled with Uhplc-Hrms-based metabolomics reveals anti-cancer integration effects of the curcuminoids of turmeric (Curcuma longa L.) on lung cancer cell line. J Pharm Biomed Anal 175:112738

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Zahra Emam-Djomeh .

Rights and permissions

Reprints and permissions

Copyright information

© 2021 The Author(s), under exclusive license to Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Miran, M., Salami, M., Emam-Djomeh, Z. (2021). Spices as Traditional Remedies: Scientifically Proven Benefits. In: Rationality and Scientific Lifestyle for Health. University of Tehran Science and Humanities Series. Springer, Cham. https://doi.org/10.1007/978-3-030-74326-0_6

Download citation

Publish with us

Policies and ethics