Abstract
The definitive treatment for primary hyperparathyroidism is surgery. Historically, as patients presented with clear complications of this disease, the value of surgery was not debated. However, with patients now typically being identified earlier in their disease course, the value and need for surgery have become a more relevant clinical question. This chapter reviews the sequelae of hyperparathyroidism and discusses the debate surrounding the indications for surgery.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Similar content being viewed by others
References
DuBose J, Ragsdale T, Morvant J. “Bodies so tiny”: the history of parathyroid surgery. Curr Surg. 2005;62:91–5. https://doi.org/10.1016/j.cursur.2004.07.012.
Toneto MG, Prill S, Debon LM, Furlan FZ, Steffen N. The history of the parathyroid surgery. Revista do Colegio Brasileiro de Cirurgioes. 2016;43(3):214–22. https://doi.org/10.1590/0100-69912016003003.
Ruda JM, Hollenbeak CS, Stack BC. A systematic review of the diagnosis and treatment of primary hyperparathyroidism from 1995 to 2003. Otolaryngol Head Neck Surg. 2005;132(3):359–72. https://doi.org/10.1016/j.otohns.2004.10.005.
Stephen AE, Mannstadt M, Hodin RA. Indications for surgical management of hyperparathyroidism: a review. JAMA Surg. 2017;152(9):878–82. https://doi.org/10.1001/jamasurg.2017.1721.
Zeng Q, Brown T, Chen RZ. Primary hyperparathyroidism: diagnosis, indications for surgery, and perioperative management. J Nurse Pract. 2019;15(10):754–6. https://doi.org/10.1016/j.nurpra.2019.08.008.
Guidoccio F, Mazzarri S, Mazzeo S, Mariani G. Diagnostic applications of nuclear medicine: parathyroid tumors. In: Nuclear oncology: from pathophysiology to clinical applications. Springer International Publishing; 2017. p. 585–612. https://doi.org/10.1007/978-3-319-26236-9_40.
Bilezikian JP. Primary hyperparathyroidism. J Clin Endocrinol Metabol. 2018;103(11):3993–4004. https://doi.org/10.1210/jc.2018-01225.
Ernst LM, Marsden L. Parathyroid gland. In: Color atlas of human fetal and neonatal histology. Springer International Publishing; 2019. p. 233–9. https://doi.org/10.1007/978-3-030-11425-1_22.
Marcocci C, Bollerslev J, Khan AA, Shoback DM. Medical management of primary hyperparathyroidism: proceedings of the fourth international workshop on the management of asymptomatic primary hyperparathyroidism. J Clin Endocrinol Metabol. 2014;99(10):3607–18. https://doi.org/10.1210/jc.2014-1417.
Zachariah SK. Management of primary hyperparathyroidism: “past, present and future”. In: Thyroid and parathyroid diseases – new insights into some old and some new issues. InTech; 2012. https://doi.org/10.5772/29587.
Assadipour Y, Zhou H, Kuo EJ, Haigh PI, Adams AL, Yeh MW. End-organ effects of primary hyperparathyroidism: a population-based study. Surgery (United States). 2019;165(1):99–104. https://doi.org/10.1016/j.surg.2018.04.088.
Beus KS, Stack BC. Parathyroid carcinoma. Otolaryngol Clin N Am. 2004;37(4):845–54. https://doi.org/10.1016/j.otc.2004.02.014.
Quinn CE, Healy J, Lebastchi AH, et al. Modern experience with aggressive parathyroid tumors in a high-volume New England referral center. J Am Coll Surg. 2015;220(6):1054–62. https://doi.org/10.1016/j.jamcollsurg.2014.10.007.
Fleet JC. The role of vitamin D in the endocrinology controlling calcium homeostasis. Mol Cell Endocrinol. 2017;453:36–45. https://doi.org/10.1016/j.mce.2017.04.008.
Rolighed L, Rejnmark L, Christiansen P. Bone involvement in primary hyperparathyroidism and changes after parathyroidectomy. Eur Endocrinol. 2014;10(1):84–7. https://doi.org/10.17925/ee.2014.10.01.84.
Saleem TFM, Horwith M, Stack BC. Significance of primary hyperparathyroidism in the management of osteoporosis. Otolaryngol Clin N Am. 2004;37(4):751–61. https://doi.org/10.1016/j.otc.2004.02.007.
Roberts WC, Waller BF. Effect of chronic hypercalcemia on the heart. An analysis of 18 necropsy patients. Am J Med. 1981;71(3):371–84. https://doi.org/10.1016/0002-9343(81)90163-7.
Brown SJ, Ruppe MD, Tabatabai LS. The parathyroid gland and heart disease. Methodist DeBakey Cardiovasc J. 2017;13(2):49–54. https://doi.org/10.14797/mdcj-13-2-49.
Bilezikian JP, Brandi ML, Eastell R, et al. Guidelines for the management of asymptomatic primary hyperparathyroidism: summary statement from the fourth international workshop. J Clin Endocrinol Metab. 2014;99(10):3561–9.
Wilhelm SM, Wang TS, Ruan DT, et al. The American association of endocrine surgeons guidelines for definitive management of primary hyperparathyroidism. JAMA Surg. 2016;151(10):959–68. https://doi.org/10.1001/jamasurg.2016.2310.
Stack BC, Tolley NS, Bartel TB, et al. AHNS series: do you know your guidelines? Optimizing outcomes in reoperative parathyroid surgery: definitive multidisciplinary joint consensus guidelines of the American Head and Neck Society and the British Association of Endocrine and Thyroid Surgeons. Head Neck. 2018;40(8):1617–29. https://doi.org/10.1002/hed.25023.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2021 Springer Nature Switzerland AG
About this chapter
Cite this chapter
Wing, S.M., Lui, M., Patel, K.N., Stack, B.C. (2021). Indications for Parathyroidectomy. In: Singer, M.C., Terris, D.J. (eds) Innovations in Modern Endocrine Surgery. Springer, Cham. https://doi.org/10.1007/978-3-030-73951-5_10
Download citation
DOI: https://doi.org/10.1007/978-3-030-73951-5_10
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-73950-8
Online ISBN: 978-3-030-73951-5
eBook Packages: MedicineMedicine (R0)