Abstract
The geographical as well as topographical position of Iran together with different climates makes it a biodiversity spot of special prominence in the world. There are more than 8000 plant species distributed in the country and many are endemics. There are 12 geographical divisions of Iran. This has allowed the growth of a large number of medicinal plants. However, in the last 30 years, medicinal plants trade has been diminished. Out of a large number of medicinal and aromatic plants, the genus Thymus is considered very important. It is distributed on a wide range of habitats. The plants from this genus are bushes with a strong root system, which is significant because of its impact on soil adjustment and growth in sloppy mountainous areas. In Iran, we find 14 Thymus species from Kotschyani and Serpyllum subsections. This chapter presents general information on these taxa mainly their ethnobotanical, phytochemical, molecular, and pharmacological features with the aim of their sustainable evaluation in the country.
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References
Abed NE, Kaabi B, Smaali MI et al (2014) Citrus lemon essential oil: chemical composition, antioxidant and antimicrobial activities with its preservative effect against Listeria monocytogenes inoculated in minced beef meat. Evid-Based Complement Altern Med 16:46
Abu-Darwish MS, Al-Ramamneh EA, Kyslychenko VS, Karpiuk UV (2012) The antimicrobial activity of essential oils and extracts of some medicinal plants grown in Ash-shoubak region-South of Jordan. Pak J Pharm Sci 25(1):239–246
Adhami HR, Mesgarpour B, Farsam H (2007) Herbal medicine in Iran. Am Bot Counc Herb Gram 74:35–43
Afrazi S, Esmaeili-Mahani S, Sheibani V, Abbasnejad M (2014) Neurosteroid allopregnanolone attenuates high glucose-induced apoptosis and prevents experimental diabetic neuropathic pain: invitro and invivo studies. J Steroid Biochem Mol Biol 139:98–103
Al-Asmari AK, Athar MT, Al-Faraidy AA, Almuhaiza MS (2017) Chemical composition of essential oil of Thymus vulgaris collected from Saudi Arabian market. Asian Pac J Trop Biomed 7(2):147–150
Alavi L, Jabbari A, Barzegar M, Naghdibadi H (2009) Chemical composition and antioxidant properties of essential oils (Lippia citriodora, Thymus daenensis). Mashhad, Iran: 18th National Congress on Food Technology
Alavi L, Barzegar M, Jabari A, Naghdi Badi H (2010) Effect of heat treatment on chemical composition and antioxidant property of Thymus daenensis essential oil. J Med Plants 9(35):129–138
Alinian S, Razmjoo J, Zeinali H (2016) Flavonoids, anthocynins, phenolics and essential oil produced in cumin (Cuminum cyminum L.) accessions under different irrigation regimes. Ind Crop Prod 81:49–55
Alizadeh A, Alizadeh O, Amari G, Zare M (2013) Essential oil composition, total phenolic content, antioxidant activity and antifungal properties of Iranian Thymus daenensis subsp. daenensis Celak. as in influenced by ontogenetical variation. J Essent Oil Bear Plants 16:59–70
Anžlovar S, Likar M, Koce JD (2017) Antifungal potential of thyme essential oil as a preservative for storage of wheat seeds. Acta Bot Croat 76(1):64–71
Askari F, Sefidkon F (2003) Essential oil composition of Thymus daenensis Celak. From Iran. J Essent Oil Bear Plants 6:217–219
Bączek K, Pióro-Jabrucka E, Kosakowska O, Węglarz Z (2019) Intraspecific variability of wild thyme (Thymus serpyllum L.) occurring in Poland. J Appl Res Med Arom Plants 12:30–35
Baharfar R, Azimi R, Mohseni M (2015) Antioxidant and antibacterial activity of flavonoid-, polyphenol-and anthocyanin-rich extracts from Thymus kotschyanus Boiss & Hohen aerial parts. J Food Sci Technol 52:6777–6783
Bahreininejad B, Razmjoo J, Mirza M (2014) Effect of water stress on productivity and essential oil content and composition of Thymus carmanicus. J Essen Oil Bear Plants 17:717–725
Bakhtiar Z, Mirjalili MH, Sonboli A (2016) In vitro callus induction and micropropagation of Thymus persicus (Lamiaceae), an endangered medicinal plant. Crop Breed Appl Biotechnol 16:48–54
Bensmira M, Jiang B, Nsabimana C, Jian T (2007) Effect of Lavender and Thyme incorporation in sunflower seed oil on its resistance to frying temperatures. Food Res Int 40:341–346
Bigdeloo M, Hadian J, Nazeri V (2017) Composition of essential oil compounds from different populations of Thymus caramanicus Jalas. J Appl Res Med Aromat Plants 7:95–98
Bjorkman M, Klingen I, Birch AN et al (2011) Phytochemicals of Brassicaceae in plant protection and human health-influences of climate, environment and agronomic practice. Phytochemistry 72:538–556
Borugă O, Jianu C, Miscă C et al (2014) Thymus vulgaris essential oil: chemical composition and antimicrobial activity. J Med Life 7(3):56–60
Boubaker H, Karim H, El Hamdaoui A et al (2016) Chemical characterization and antifungal activities of four Thymus species essential oils against postharvest fungal pathogens of citrus. Ind Crop Prod 86:95–101
Checcucci A, Maida I, Bacci G et al (2016) Is the plant-associated microbiota of Thymus spp. adapted to plant essential oil? Res Microbiol 168(3):276–282
Chudzik M, Korzonek-Szlacheta I, Krol W (2015) Triterpenes as potentially cytotoxic compounds. Molecules 20:1610–1625
Costa P, Medronho B, Goncalves S, Romano A (2015) Cyclodextrins enhance the antioxidant activity of essential oils from three Lamiaceae species. Ind Crop Prod 70:341–346
Crocoll C, Asbach J, Novak J et al (2010) Terpene synthases of oregano (Origanum vulgare L.) and their roles in the pathway and regulation of terpene biosynthesis. Plant Mol Biol 73:587–593
Cronquist A (1988) The evolution and classification of flowering plants. The New York Botanical Garden, New York
Croteau R, Burbott AJ, Loomis WD (1972) Biosynthesis of mono- and sesquiterpenes in peppermint from glucose – 14C and 14CO2. Phytochemistry 11:2459–2467
Dadashpour M, Rasooli I, Sefidkon F, Rezaei MB (2011a) Lipid peroxidation inhibition, superoxide anion and nitric oxide radical scavenging properties of Thymus daenensis and anethumgraveolens essential oils. J Med Plants 10:109–120
Dadashpour M, Rasooli I, Sorouri Zanjani R et al (2011b) Antimicrobial, nitric oxide radical scavenging and cytotoxic properties of Thymus daenensis essential oil. Modarres J Med Sci 14:37–47
Daviet L, Schalk M (2010) Biotechnology in plant essential oil production: progress and perspectives in metabolic engineering of the terpene pathway. Flavour Fragr J 25:123–127
Davis EM, Croteau R (2000) Cyclization enzymes in the biosynthesis of monoterpenes, sesquiterpenes, and diterpenes. In: Topics in current chemistry, vol 209. Springer, Berlin/Heidelberg, pp 54–95
De Lira Mota KS, de Oliveira PF, de Oliveira WA et al (2012) Antifungal activity of Thymus vulgaris L. essential oil and its constituent phytochemicals against Rhizopus oryzae: interaction with ergosterol. Molecules 17(12):14418–14433
Debonne E, Van Bockstaele F, De Leyn I et al (2018) Validation of in-vitro antifungal activity of thyme essential oil on Aspergillus niger and Penicillium paneum through application in par-baked wheat and sourdough bread. Lwt J Food Sci Tech 87:368–378
Degenhardt J, Köllner TG, Gershenzon J (2009) Monoterpene and sesquiterpene synthases and the origin of terpene skeletal diversity in plants. Phytochemistry 70:1621–1637
Dehghani Mashkani MR, Larijani K, Mehrafarin A, NaghdiBadi H (2018) Changes in the essential oil content and composition of Thymus daenensis Celak. under different drying methods. Ind Crop Prod 112:389–395
El Bouzidi L, Jamali CA, Bekkouche K et al (2013) Chemical composition, antioxidant and antimicrobial activities of essential oils obtained from wild and cultivated Moroccan Thymus species. Ind Crop Prod 43:450–456
El-Nekeety AA, Mohamed SR, Hathout AS et al (2011) Antioxidant properties of Thymus vulgaris oil against aflatoxin-induce oxidative stress in male rats. Toxicon 57(7–8):984–991
Emami Bistgani Z, Sefidkon F (2019) Review on ethnobotany, phytochemical, molecular and pharmacological activity of Thymus daenensis Celak. Biocatal Agric Biotechnol 22:101400
Emami Bistgani Z, Siadat SA, Bakhshandeh A et al (2016) Influence of chitosan concentration on morpho-physiological traits, essential oil and phenolic content under different fertilizers application in Thymus daenensis. J Herb Drugs 7:117–125
Emami Bistgani Z, Siadat SA, Bakhshandeh A et al (2017a) Interactive effects of drought stress and chitosan application on physiological characteristics and essential oil yield of Thymus daenensis Celak. Crop J 5:407–415
Emami Bistgani Z, Siadat SA, Bakhshandeh A et al (2017b) Morpho-physiological and phytochemical traits of (Thymus daenensis Celak.). In response to deficit irrigation and chitosan application. Acta Physiol Plant 39:231
Emami Bistgani Z, Siadat SA, Bakhshandeh A et al (2018) Application of combined fertilizers improves biomass, essential oil yield, aroma profile, and antioxidant properties of Thymus daenensis Celak. Ind Crop Prod 121:434–440
Emami Bistgani Z, Hashemi M, DaCosta M et al (2019) Effect of salinity stress on the physiological characteristics, phenolic compounds and antioxidant activity of Thymus vulgaris L. and Thymus daenensis Celak. Ind Crop Prod 135:311–320
Eraky MA, El-Fakahany AF, El-Sayed NM et al (2016) Effects of Thymus vulgaris ethanolic extract on chronic toxoplasmosis in a mouse model. Parasitol Res 115(7):2863–2871
Ezzatzadeh E, Pourghasem E, Sofla SFI (2014) Chemical composition and antimicrobial activity of the volatile oils from leaf, flower, stem and root of Thymus transcaucasicus from Iran. J Essen Oil Bear Plants 17:577–583
Ferreira LE, Benincasa BI, Fachin AL et al (2016) Thymus vulgaris L. essential oil and its main component thymol: anthelmintic effects against Haemonchus contortus from sheep. Vet Parasitol 228:70–76
Figueiredo AC, Barroso JG, Pedro LG, Scheffer JJC (2008) Factors affecting secondary metabolite production in plants: volatile components and essential oils. Flavour Fragr J 23:213–226
Fischer MJC, Meyer S, Claudel P et al (2013) Specificity of Ocimum basilicum geraniol synthase modified by its expression in different heterologous systems. J Biotechnol 163:24–29
Gershenzon J, Croteau R (1991) Terpenoids. In: Rosenthal GA, Berenbaum MR (eds) Herbivores: their interactions with secondary plant metabolites, the chemical participants, 2nd ed, vol I. Academic, San Diego, pp 165–219
Gershenzon J, Dudareva N (2007) The function of terpene natural products in the natural. Nat Chem Biol 3:408–414
Ghasemi Pirbalouti A (2009) Medicinal plants used in Chaharmahal and Bakhtyari districts, Iran. Herba Pol 55:69–75
Ghasemi Pirbalouti A, Jahanbazi P, Enteshari S et al (2010) Antimicrobial activity of some Iranian medicinal plants. Arch Biol Sci 62:633–641
Ghasemi Pirbalouti A, Karimi A, Yousefi M et al (2011a) Diversity of Thymus daenensis Celak in central and west of Iran. J Med Plants Res 5:319–323
Ghasemi Pirbalouti A, Rahimmalek M, Malekpoor F, Karimi A (2011b) Variation in antibacterial activity, thymol and carvacrol contents of wild populations of’ Thymus daenensis subsp. daenensis’ Celak. Plant Omics 4:209–214
Ghasemi Pirbalouti A, Hashemi M, Taherian Ghahfarokhi F (2013) Essential oil and chemical compositions of wild and cultivated (Thymus daenensis Celak.) and (Thymus vulgaris L.). Ind Crop Prod 48:43–48
Ghasemi Pirbalouti A, Samani MR, Hashemi M, Zeinali H (2014) Salicylic acid affects growth, essential oil and chemical compositions of thyme (Thymus daenensis Celak.) under reduced irrigation. Plant Growth Regul 72:289–301
Ghasemi Pirbalouti A, Emami Bistghani Z, Malekpoor F (2015) An overview on genus Thymus. J. Herb. Drugs 6 (2): 93–100
Golparvar AR, Gheisari MM, Naderi D et al (2015) Diversity of chemical components of Denaian thyme (Thymus daenensis Celak.) collected from Semirom Province, Iran. Res Crops 16:764–767
Gonçalves ND, Pena Fde L, Sartoratto A et al (2017) Encapsulated thyme (Thymus vulgaris) essential oil used as a natural preservative in bakery product. Food Res Int 96:154–160
Gorran A, Farzaneh M, Shivazad M et al (2013) Aflatoxin B1-reduction of Aspergillus flavus by three medicinal plants (Lamiaceae). Food Control 31(1):218–223
Granger R, Passet J (1973) Thymus vulgaris spontane de France: races chimiques et chemotaxonomie. Phytochemistry 112:1683–1691
Grausgruber-Gröger S, Schmiderer C, Steinborn R, Novak J (2012) Seasonal influence on gene expression of monoterpene synthases in Salvia officinalis (Lamiaceae). J Plant Physiol 169:353–359
Guillen MD, Manzanos MJ (1998) Study of composition of different parts of a Spanish Thymus vulgaris L. plant. Food Chem 3:373–383
Gutensohn M, Nagegowda DA, Dudareva N (2012) Involvement of compartmentalization in monoterpene and sesquiterpene biosynthesis in plants. In: Bach T, Rohmer M (eds) Isoprenoid synthesis in plants and microorganisms. Springer, New York
Hadian J, Mirjalilia MH, Kananib MR et al (2011) Phytochemical and morphological characterization of Satureja khuzistanica Jamzad populations from Iran. Chem Biodivers 8:902–915
Hajializadeh Z, Nasri S, Kaeidi A et al (2014) Inhibitory effect of Thymus caramanicus Jalas on hyperglycemia-induced apoptosis in in vitro and in vivo models of diabetic neuropathic pain. J Ethnopharmacol 153:596–603
Harkat-Madouri L, Asma B, Madani Said ZBOS et al (2015) Chemical composition, antibacterial and antioxidant activities of essential oil of Eucalyptus globulus from Algeria. Ind Crop Prod 78:148–153
Hashemi P, Abolghasemi MM, Hassanvand H, Ahmadi S (2010) Headspace solvent microextraction of volatile components of Thymus daenensis. J Essent Oil Res 22:365–368
Hashemi-Moghaddam H, Mohammadhosseini M, Salar M (2014) Chemical composition of the essential oils from the hulls of Pistacia vera L. by using magnetic nanoparticle- assisted microwave (MW) distillation: comparison with routine MW and conventional hydrodistillation. Anal Methods 6:2572–2579
Hashemi-Moghaddam H, Mohammadhosseini M, Basiri M (2015) Optimization of microwave assisted hydrodistillation on chemical compositions of the essential oils from the aerial parts of Thymus pubescens and comparison with conventional hydrodistllation. J Essent Oil-Bear Plants 18:884–893
Hosseinzadeh S, Kukhdan A, Hosseini A, Armand R (2015a) The application of Thymus vulgaris in traditional and modern medicine: a review. Glob J Pharmacol 9(3):260–266
Hosseinzadeh S, Jafarikukhdan A, Hosseini A, Armand R (2015b) The application of medicinal plants in traditional and modern medicine: a review of Thymus vulgaris. Int J Clin Exp Med 6:635–642
Inanç T, Maskan M (2012) The potential application of plant essential oils/extracts as natural preservatives in oils during processing: a review. J Food Sci 2:1–9
Jaafari N, Hadavi E (2012) Growth and essential oil yield of basil (Ocimum basilicum L.) as affected by foliar spray of citric acid and salicylic acid. Z Arznei-Gewurzpfla 17:80–83
Jahanshir S (2013) Fumigant toxicity of four plant essential oils against Tribolium castaneum (Herbst) and T. confusum (Du VaL.). Tech J Engin App Sci 3(22):3158–3162
Jamzad Z (2009a) Thymus and Satureja species of Iran. Islamic Republic of Iran. Ministry of Jihad-e- Agriculture. Agricultural Research, Education and Extension Organization. Research Institute of Forests and Rangelands, Tehran, Iran
Jamzad Z (2009b) New species and new plant records of Lamiaceae from Iran. Iran J Bot 15(1):52–56
Juárez-Rosete CR, Aguilar-Castillo JA, Rodríguez-Mendoza MN (2014) Fertilizer source in biomass production and quality of essential oils of thyme (Thymus vulgaris L.). Eur J Med Plants 4:865–871
Jukić M, Miloš M (2005) Catalytic oxidation and antioxidant properties of thyme essential oils (Thymus vulgarae L.). Croat Chem Acta 78:105–110
Kalemba D, Kunicka A (2003) Antibacterial and antifungal properties of essential oils. Curr Med Chem 10(10):813–829
Kalvandi R, Sefidkon F, Atri M, Mirza M (2004) Analysis of the essential oil of Thymus eriocalyx from Iran. Flavour Fragr J 19:341–343
Kamboj SS, Vasishta RK, Sandhir R (2010) N-acetylcysteine inhibits hyperglycemia-induced oxidative estress and apoptosis markers in diabetic neuropathy. J Neurochem 112:77–91
Karoui IJ, Dhifi W, Ben Jemia M, Marzouk B (2011) Thermal stability of corn oil flavored with Thymus capitatus under heating and deep-frying conditions. J Sci Food Agric 91(5):927–933
Katar D, Kacar O, Kara N et al (2017) Ecological variation of yield and aroma components of summer savory (Satureja hortensis L.). J Appl Res Med Aromat Plants 7:131–135
Khoshsokhan F, Poormeidani A, Babalar M, Moghadam MF (2014) Analysis of the essential oils of Thymus kotschyanus L. (10 populations) from Iran. Cercet Agron Mold 47:49–59
Kizil S (2010) Determination of essential oil variations of Thymbra spicata var. spicata naturally growing in the wild flora of east Mediterranean and southeastern Anatolia regions of Turkey. Ind Crop Prod 32:593–600
Kocabas YZ, Karaman S (2001) Essential oils of Lamiaceae family from south east Mediterranean region (Turkey). Pak J Biol Sci 4:1221–1223
Kohiyama CY, Yamamoto Ribeiro MM, Mossini SAG et al (2015) Antifungal properties and inhibitory effects upon aflatoxin production of Thymus vulgaris L. by Aspergillus flavus Link. Food Chem 173:1006–1010
Kuete V (2017) Thymus vulgaris. In: Medicinal spices and vegetables from Africa. Elsevier, Amsterdam, pp 599–609
Kutasi J, Jakab L, Jurkovich V, Rafai P (2016) The in vitro effect of garden thyme (Thymus vulgaris L.) extract on Brachyspira hyodysenteriae. Acta Microbiol Imm H 63(4):467–473
Lee KG, Shibamoto T (2002) Determination of antioxidant potential of volatile extracts isolated from various herbs and spices. J Agric Food Chem 50(17):4947–4952
Lee GW, Lee S, Chung MS et al (2015) Rice terpene synthase 20(OsTPS20) plays an important role in producing terpene volatiles in response to abiotic stresses. Protoplasma 252:997–1007
Letchamo W, Xu HL, Gosselin A (1995) Variations in photosynthesis and essential oil in thyme. J Plant Physiol 147:29–37
López P, Sánchez C, Batlle R, Nerín C (2007) Vapor-phase activities of cinnamon, thyme, and oregano essential oils and key constituents against foodborne microorganisms. J Agric Food Chem 55(11):4348–4356
Mahdavi S, Karimzadeh G (2010) Karyological and nuclear DNA content variation in some Iranian endemic Thymus species (Lamiaceae). J Agric Sci Technol 12:447–458
Majdi M, Malekzadeh Mashhady A, Maroufi A, Crocoll C (2017) Tissue-specific gene-expression patterns of genes associated with thymol/carvacrol biosynthesis in thyme (Thymus vulgaris L.) and their differential changes upon treatment with abiotic elicitors. Plant Physiol Bioch 115:152–162
Mandal S, DebMandal M (2016) Thyme (Thymus vulgaris L.) oils. In: Preedy V (ed) Essential oils in food preservation, flavor and safety. Chapter 94. Academic, Cambridge, pp 825–834
Marinelli O, Iannarelli R, Morelli MB et al (2016) Evaluations of thyme extract effects in human normal bronchial and tracheal epithelial cell lines and in human lung cancer cell line. Chem Biol Interact 256:125–133
Martin DM, Aubourg S, Schouwey MB et al (2010) Functional annotation, genome organization and phylogeny of the grapevine (Vitis vinifera) terpene synthase gene family based on genome assembly, FLcDNA cloning, and enzyme assays. BMC Plant Biol 10:226
Masoodi KZ, Amin I, Mansoor S et al (2020) Botanicals from the Himalayas with anticancer potential – an emphasis on Kashmir Himalayas. In: Munir Ozturk M, Egamberdieva D, Pešić M (eds) Biodiversity and biomedicine – our future. Chapter 11. Academic, London, pp 189–234
Matusinsky P, Zouhar M, Pavela R, Novy P (2015) Antifungal effect of five essential oils against important pathogenic fungi of cereals. Ind Crop Prod 67:208–215
Mendes MD, Barroso JG, Oliveira MM, Trindade H (2014) Identification and characterization of a second isogene encoding γ-terpinene synthase in Thymus caespititius. J Plant Physiol 171:1017–1027
Miladi H, Slama R, Mili D et al (2013) Essential oil of Thymus vulgaris L. and Rosmarinus officinalis L.: gas chromatography-mass spectrometry analysis, cytotoxicity and antioxidant properties and antibacterial activities against foodborne pathogens. Nat Sci 5:729–739
Mint Evolutionary Genomics Consortium (2018) Phylogenomic mining of the mints reveals multiple mechanisms contributing to the evolution of chemical diversity in Lamiaceae. Mol Plant 11:1084–1096
Mirzaee A, Jaberi Hafashani H, Madani AH (2012) Antioxidant activities, total phenols and total flavonoids assay of Origanurm vulgare, Teucrium polium and Thymus daensis. Hormozgan Med J 15(4):285–294
Moazeni N, Khajeali J, Izadi H, Mahdian K (2013) Chemical composition and bioactivity of Thymus daenensis Celak (Lamiaceae) essential oil against two lepidopteran stored-product insects. J Essent Oil Res 26(2):118–124
Mohammadhosseini M, Mahdavi B, Akhlaghi H (2013) Characterization and chemical composition of the volatile oils from aerial parts of Eryngium bungei Bioss. (Apiaceae) by using traditional hydrodistillation, microwave assisted hydrodistillation and head space solid phase microextraction methods prior to GC and GC/MS analyses: a comparative approach. J Essent Oil-Bear Plants 16:613–623
Mohammadhosseini M, Mahdavi B, Shahnama M (2015) Chemical composition of essential oils from aerial parts of Ferula gummosa (Apiaceae) in Jajarm Region, Iran using traditional hydrodistillation and solvent-free microwave extraction methods: a comparative approach. J Essent Oil-Bear Plants 18:1321–1328
Mohammadhosseini M, Akbarzadeh A, Hashemi-Moghaddam H (2016) Gas chromatographic- mass spectrometric analysis of volatiles obtained by HS-SPME-GC-MS technique from Stachys lavandulifolia and evaluation for biological activity: a review. J Essent Oil-Bear Plants 19:1300–1327
Mohammadhosseini M, Sarker SD, Akbarzadeh A (2017) Chemical composition of the essential oils and extracts of Achillea species and their biological activities: a review. J Ethnopharmacol 199:257–315
Mohammadi A, Nazari H, Imani S, Amrollahi H (2014) Antifungal activities and chemical composition of some medicinal plants. J Mycol Med 24(2):24
Mohammadi H, Amirikia F, Ghorbanpour M et al (2019) Salicylic acid induced changes in physiological traits and essential oil constituents in different ecotypes of Thymus kotschyanus and Thymus vulgaris under well-watered and water stress conditions. Ind Crop Prod 129:561–574
Mohasseli V, Sadeghi S (2019) Exogenously applied sodium nitroprusside improves physiological attributes and essential oil yield of two drought susceptible and resistant specie of Thymus under reduced irrigation. Ind Crop Prod 130:130–136
Mojab F, Poursaeed M, Mehrgan H, Pakdaman S (2008) Antibacterial activity of Thymus daenensis methanolic extract. Pak J Pharm Sci 21:210–213
Morshedloo MR, Quassinti L, Bramucci M et al (2017) Chemical composition, antioxidant activity and cytotoxicity on tumour cells of the essential oil from flowers of Magnolia grandiflora cultivated in Iran. Nat Prod Res 31:2857–2864
Mousavi A, Ghahremaninejad F (2017) Morphological and chemical diversity of Thymus daenensis Celak (Lamiaceae) in Iran. RRJOB 5:1–8
Mozaffarian V (2008) A pictorial dictionary of botany botanical taxon-Omy Latin–English–French–Germany–Persian/complied. Farahang Moaser, Tehran, p 522
Nabavi SM, Marchese A, Izadi M et al (2015) Plants belonging to the genus Thymus as antibacterial agents: from farm to pharmacy. Food Chem 173:339–347
Nagegowda DA (2010) Plant volatile terpenoid metabolism: biosynthetic genes, transcriptional regulation and subcellular compartmentation. FEBS Lett 584:2965–2973
Nejad Ebrahimi S, Hadian J, Mirjalili MH et al (2008) Essential oil composition and antibacterial activity of Thymus caramanicus at different phenological stages. Food Chem 110:927–931
Nekoei M, Mohammadhosseini M (2017) Chemical composition of essential oils of Salvia leriifolia by three different extraction methods prior to gas chromatographicmass spectrometric determination: comparison of HD with SFME and HS-SPME. J Essent Oil Bear Plants 20:410–425
Nickavar B, Mojab F, Dolat-Abadi R (2005) Analysis of the essential oils of two Thymus species from Iran. Food Chem 90:609–611
Nikkhah M, Hashemi M, Habibi Najafi MB, Farhoosh R (2017) Synergistic effects of some essential oils against fungal spoilage on pear fruit. Int J Food Microbiol 257:285–294
Nikolić M, Glamočlija J, Ferreira IC et al (2014) Chemical composition, antimicrobial, antioxidant and antitumor activity of Thymus serpyllum L., Thymus algeriensis Boiss. and Reut and Thymus vulgaris L. essential oils. Ind Crop Prod 52:183–190
Ozturk M, Gork G (1978a) Biotic and abiotic factors effecting the distribution of Mentha species in West Anatolia. Plant 2:155–165
Ozturk M, Gork G (1978b) Studies on the chorology and economical evaluation of Mentha species in West Anatolia. Ege Univ Sci Fac J II(4):339–356
Ozturk M, Gork G (1979a) Ecological factorsF effecting the distribution and plasticity of Mentha species in West Anatolia. Plant 6:39–51
Ozturk M, Gork G (1979b) Studies on the morphology and taxonomy of Mentha species in West Anatolia. Ege Univ Sci Fac J III:43–55
Ozturk M, Gork G (1979c) Ecology of Mentha pulegium. Ege Univ Sci Fac J III:57–72
Ozturk M, Gork G (1979d) Edaphic relations of Mentha species in West Anatolia. Ege Univ Sci Fac J III:95–110
Ozturk M, Hakeem KR (2018) Plant and human health – vol. 1 – ethnobotay and physiology. Springer Science + Business Media, Cham
Ozturk M, Hakeem KR (2019a) Plant and human health – vol. 2 – phytochemistry and molecular aspects. Springer Science + Business Media, Cham
Ozturk M, Hakeem KR (2019b) Plant and human health – vol. 3 – phytochemistry and therapeutic uses. Springer + Business Media, Cham
Ozturk M, Altay V, Gucel S, Altundağ E (2017a) Plant diversity of the drylands in Southeast Anatolia-Turkey: role in human health and food security. In: Ansari AA, Gill SS (eds) Plant biodiversity: monitoring, assessment and conservation. Chapter 5. CABI, Wallingford, pp 83–124
Ozturk M, Altay V, Gonenç TM (2017b) Herbal from high mountains in the East Mediterranean. In: Bhojraj S et al (eds) Drug discovery from herbs-approaches and applications. Chapter 24. NAM S & T Centre, DAYA Publishing House, New Delhi, pp 327–367
Ozturk M, Altay V, Hakeem KR, Akçiçek E (2017c) Liquorice from botany to phytochemistry, SpringerBriefs in plant science. Springer, Cham. https://doi.org/10.1007/978-3-319-74240-3
Ozturk M, Altay V, Latiff A et al (2018a) A comparative analysis of the medicinal pteridophytes in Turkey, Pakistan, and Malaysia. In: Ozturk M, Hakeem KR (eds) Plant and human health, vol. 1, chapter 9. Springer International Publishing AG, part of Springer Nature, Cham, pp 349–390
Ozturk M, Altay V, Latiff A et al (2018b) A comparative analysis of the medicinal plants used for diabetes mellitus in the traditional medicine in Turkey, Pakistan, and Malaysia. In: Ozturk M, Hakeem KR (eds) Plant and human health, vol. 1, chapter 11. Springer International Publishing AG, part of Springer Nature, Cham, pp 409–461
Ozturk M, Altay V, Latiff A et al (2018c) Potential medicinal plants used in the hypertension in Turkey, Pakistan, and Malaysia. In: Ozturk M, Hakeem KR (eds) Plant and human health, vol. 1, chapter 16. Springer International Publishing AG, part of Springer Nature, Cham, pp 595–618
Ozturk M, Gökler I, Altay V (2018d) Medicinal bryophytes distributed in Turkey. In: Ozturk M, Hakeem KR (eds) Plant and human health. vol. 1, chapter 8, vol 2018. Springer International Publishing AG, part of Springer Nature, Cham, pp 323–348
Ozturk M, Altundağ E, Ibadullayeva SJ et al (2018e) A comparative analysis of medicinal and aromatic plants used in the traditional medicine of Iğdır (Turkey), Nakhchivan (Azerbaijan), and Tabriz (Iran). Pak J Bot 50(1):337–343
Ozturk M, Altay V, Altundağ E et al (2018f) Herbals in Iğdır (Turkey), Nakhchivan (Azerbaijan), and Tabriz (Iran). In: Ozturk M, Hakeem KR (eds) Plant and human health, Chapter 6, vol 1. Springer, Cham, pp 197–266
Pavela R (2011) Insecticidal and repellent activity of selected essential oils against of the pollen beetle, Meligethes aeneus. Industrial Crops & Products 34:888–892
Pavela R, Benelli G (2016) Essential oils as ecofriendly biopesticides? Challenges and constraints. Trends Plant Sci 21:1000–1007
Pavela R, Žabka M, Vrchotová N, Tříska J (2018) Effect of foliar nutrition on the essential oil yield of Thyme (Thymus vulgaris L.). Ind Crop Prod 112:762–765
Petrović NV, Petrović SS, Džamić AM et al (2016) Chemical composition, antioxidant and antimicrobial activity of Thymus praecox supercritical extracts. J Supercrit Fluid 110:117–125
Petrović S, Ušjak L, Milenković M et al (2017) Thymus dacicus as a new source of antioxidant and antimicrobial metabolites. J Funct Foods 28:114–121
Pirbalouti AG, Bahmani M, Avijgan M (2009) Anti-Candida activity of some of the Iranian medicinal plants. Electron J Biol 5(4):855–858
Pleskanovskaya SA, Mamedova MA, Ashıralıyeva MA et al (2019) Glycyrrhiza glabra (Liquorice) in Turkmenistan – medicinal and biological aspects. In: Ozturk M, Hakeem KR (eds) Plant and human health, − pharmacology and therapeutic uses, vol. 3, chapter 2. Springer Nature, Cham, pp 23–35
Rabiei B, Bahador S, Kordrostami M (2018) The expression of monoterpene synthase genes and their respective end products are affected by gibberellic acid in Thymus vulgaris. J Plant Physiol 230:101–108
Rahimmalek M, Bahreininejad B, Khorrami M, Sayed Tabatabaei BE (2009) Genetic variability and geographical differentiation in Thymus daenensis subsp. daenensis Cleak, an endangered aromatic and medicinal plant as revealed by Inter Simple Sequence Repeat (ISSR) markers. Biochem Genet 47:831–842
Ramak P, Kazempour Osalooa SH, Ebrahimzadeh H et al (2013) Inhibition of the mevalonate pathway enhances carvacrol biosynthesis and DXR gene expression in shoot cultures of Satureja khuzistanica Jamzad. J Plant Physiol 170:1187–1193
Rasooli I, Mirmostafa SA (2002) Antibacterial properties of Thymus pubescens and Thymus serpyllum essential oils. Fitoterapia 73:244–250
Reddy P, Kandisa R, Varsha P, Satyam S (2014) Review on Thymus vulgaris traditional uses and pharmacological properties. Med Aromat Plants 3:164
Rivas L, McDonnell MJ, Burgess CM et al (2010) Inhibition of verocytotoxigenic Escherichia coli in model broth and rumen systems by carvacrol and thymol. Int J Food Microbiol 139(1–2):70–78
Roeder S, Hartmann AM, Effmert U, Piechulla B (2007) Regulation of simultaneous synthesis of floral scent terpenoids by the 1,8-cineole synthase of Nicotiana suaveolens. Plant Mol Biol 65:107–124
Rowshan V, Bahmanzadegan A, Saharkhiz MJ (2013) Influence of storage conditions on the essential oil composition of Thymus daenensis Celak. Ind Crop Prod 49:97–101
Rustaiee A, Sefidkon F, Tabatabaei SMF et al (2011) Chemical polymorphism of essential oils from five populations of Thymus daenensis Celak. Subsp. daenensis endemic to Iran. J Essen Oil Res 23:6–11
Sabahi Z, Zarshenas MM, Farmani F et al (2013) Essential oil composition and in vitro antioxidant activity of ethanolic extract of Thymus daenensis Celak from Iran. Glob J Pharmacol 7(2):153–158
Sadgrove N, Jones G (2015) A contemporary introduction to essential oils: chemistry, bioactivity and prospects for Australian agriculture. Agriculture 5:48–102
Saeidi K, Yousefi M (2013) Essential oil and antifeedant activity of Zataria multiflora Boiss and Thymus daenensis Celak on Plodia interpunctella Hubner. Int J Med Aromat Plants 3(2):151–158
Safaei-Ghomi J, Ebrahimabadi AH, Djafari-Bidgoli Z, Batooli H (2009) GC/MS analysis and in vitro antioxidant activity of essential oil and methanol extracts of Thymus caramanicus Jalas and its main constituent carvacrol. Food Chem 115:1524–1528
Saidi M (2014) Antioxidant activities and chemical composition of essential oils from Satureja khuzestanica, Oliveria decumbens and Thymus daenensis. J Essen Oil Bear Plants 17:513–521
Sajadi A, Naderi GH (2004) Antioxidant effects of some medicinal plants (Labiatae family). J Kermanshah Univ Med Sci 8(2):1–12
Sajjadi SE, Khatamsaz M (2003) Composition of the essential oil of Thymus daenensis Celak. ssp. lancifolius (Celak.) Jalas. J Essen Oil Res 15:34–35
Salehi B, Abu-Darwish MS, Tarawneh AH et al (2019) Thymus spp. plants – food applications and phytopharmacy properties. Trends Food Sci Technol 85:287–306
Schmiderer C, Grausgruber-Gröger S, Grassi P et al (2010) Influence of gibberellin and daminozide on the expression of terpene synthases and on monoterpenes in common sage (Salvia officinalis). J Plant Physiol 167:779–786
Sefidkon F, Jamzad Z (2006) Essential oil analysis of Iranian Satureja edmondi and S. isophylla. Flav Fragr J 21:230–233
Sefidkon F, Dabiri M, Mirmostafa SA (2004) The composition of Thymus serpyllum L. oil. J Essent Oil Res 16:184–185
Sefidkon F, Abbasi KH, Jamzad Z, Ahmadi SH (2007) The effect of distillation methods and stage of plant growth on the essential oil content and composition of Satureja rechingeri Jamzad. Food Chem 100:1054–1058
Sefidkon F, Emami Bistgani Z (2021) Integrative review on ethnobotany, essential oil, phytochemical, agronomy, molecular and pharmacological properties of Satureja species. J. Essent. Oil Res 1–19
Segvic Klaric M, Kosalec I, Mastelic J et al (2007) Antifungal activity of thyme (Thymus vulgaris L.) essential oil and thymol against moulds from damp dwellings. Lett Appl Microbiol 44(1):36–42
Sfeir J, Lefrancois C, Baudoux D et al (2013) In vitro antibacterial activity of essential oils against Streptococcus pyogenes. Evid Based Complement Alternat Med 2013:269161
Sharafzadeh S, Alizadeh O (2012) Some medicinal plants cultivated in Iran. J Appl Pharm Sci 2:134–137
Sharafzadeh S, Alizadeh O, Vakili M (2011) Effect of nitrogen sources and levels on essential oil components of Thymus vulgaris L. Aust J Basic Appl Sci 5:885–889
Sharifi Ashour Abadi E, Jamzad Z, Mirza M et al (2019) Thymus Atlas of Iran. Ministry of Agricultural Jihad, Agricultural Research, Education and Extension Organization. Research Institute Forests and Rangelands, pp 1–296
Shayganfar A, Azizia M, Rasouli M (2018) Various strategies elicited and modulated by elevated UV-B radiation and protectant compounds in Thymus species: differences in response over treatments, acclimation and interaction. Ind Crop Prod 113:298–307
Sienkiewicz M, Lysakowska M, Ciecwierz J et al (2011) Antibacterial activity of thyme and lavender essential oils. Med Chem 7(6):674–689
Soliman KM, Badeaa RI (2002) Effect of oil extracted from some medicinal plants on different mycotoxigenic fungi. Food Chem Toxicol 40(11):1669–1675
Sonboli A, Mirjalili MH, Bakhtiar Z, Jamzad Z (2013) Molecular authentication of Thymus persicus based on nrdna its sequences data. Iran J Bot 19(2):180–185
Srivastava NK, Luthra R (1991a) Distribution of photosynthetically fixed 14CO2 into essential oil in relation to primary metabolites in developing peppermint (Mentha piperita) leaves. Plant Sci 76:153–157
Srivastava NK, Luthra R (1991b) Interspecific variation in mints for photosynthetic efficiency, and 14C primary metabolic pool in relation to essential oil accumulation. J Plant Physiol 138:650–654
Stahl-Biskup E, Saez F (2002) Thyme the genus Thymus. Taylor & Francis, New York
Stahl-Biskup E, Venskutonis RP (2012) Thyme. In: Peter KV (ed) Handbook of herbs and spices, 2nd edn. Woodhead Publishing, Abington/Cambridge, pp 499–525
Szczepanik M, Zawitowska B, Szumny A (2012) Insecticidal activities of Thymus vulgaris essential oil and its components (thymol and carvacrol) against larvae of lesser mealworm, Alphitobius diaperinus Panzer (Coleoptera: Tenebrionidae). Allelopath J 30:129
Tajkarimi MM, Ibrahim SA, Cliver DO (2010) Antimicrobial herb and spice compounds in food. Food Control 21(9):1199–1218
Teoh SL, Das S (2018) Phytochemicals and their effective role in the treatment of diabetes mellitus: a short review. Phytochem Rev 17(5):1111–1128
Tholl D (2006) Terpene synthases and the regulation, diversity and biological roles of terpene metabolism. Curr Opin Plant Biol 9:297–304
Thompson JD (2000) Population structure and the spatial dynamics of genetic polymorphism in thyme. In: Letchamo W, Saez F, Stahl-Biskup E (eds) Medicinal and aromatic plants-industrial profiles: the genus Thymus. Harwood Academic Publishers, Amsterdam
Thompson JD, Chalchat JC, Michet A et al (2003) Qualitative and quantitative variation in monoterpene co-occurrence and composition in the essential oil of Thymus vulgaris chemotypes. J Chem Ecol 29:859–880
Thompson JD, Gauthier P, Amiot J et al (2007) Ongoing adaptation to Mediterranean climate extremes in a chemically polymorphic plant. Ecol Monogr 77:421–439
Tohidi B, Rahimmalek M, Arzani A (2017) Essential oil composition, total phenolic, flavonoid contents, and antioxidant activity of Thymus species collected from different regions of Iran. Food Chem 220:153–161
Tohidi B, Rahimmalek M, Arzani A (2018) Variations in chemical composition and bioactive compounds of Thymus kotschyanus boiss. & hohen populations originated from different collection sites. J Essent Oil Bear Plants 2:1272–1283
Tohidi B, Rahimmalek M, Trindade H (2019) Review on essential oil, extracts composition, molecular and phytochemical properties of Thymus species in Iran. Ind Crop Prod 134:89–99
Trapp SC, Croteau RB (2001) Genomic organization of plant terpene synthases and molecular evolutionary implications. Genetics 158:811–832
Trindade H, Gaspar Pedro L, Cristina Figueiredo A, Gonçalves Barroso J (2018) Chemotypes and terpene synthase genes in Thymus genus: state of the art. Ind Crop Prod 124:530–547
Turkyilmaz Unal B, Guvensen A, Esiz Dereboylu A, Ozturk M (2013) Variations in the proline and total protein contents in Origanum sipyleum L. from different altitudes of Spil Mountain, Turkey. Pak J Bot 45(S1):571–576
Venskutonis PR (2004) Food additives: the dilemma of synthetic or natural. Acta Aliment 33(1):1–5
Viacava GE, Ayala-Zavala JF, González-Aguilar GA, Ansorena MR (2018) Effect of free and microencapsulated thyme essential oil on quality attributes of minimally processed lettuce. Postharvest Biol Technol 145:125–133
Yavari A, Nazeri V, Sefidkon F, Hassani ME (2010) Influence of some environmental factors on the essential oil variability of Thymus migricus. Nat Product Commun 5:943–948
Younessi-Hamzekhanlu M, Ozturk M, Altay V et al (2020) Ethnopharmacological study of medicinal plants from Khoy city of West Azerbaijan-Iran. Indian J Tradit Knowl 19(2):251–267
Zantar S, Yedri F, Mrabet R et al (2014) Effect of Thymus vulgaris and Origanum compactum essential oils on the shelf life of fresh goat cheese. J Essent Oil Res 26(2):76–84
Zargari A (1989–1992) Medicinal plants. Tehran University Press, Tehran
Zargari A (1990) Medicinal plants. Tehran University Press 4:28–42
Zarshenas MM, Krenn L (2015) A critical overview on Thymus daenensis Celak.: phytochemical and pharmacological investigations. J Integr Med 13:91–98
Zeljković SĆ, Maksimović M (2015) Chemical composition and bioactivity of essential oil from Thymus species in Balkan Peninsula. Phytochem Rev 14:335–352
Zhiani R, Dolatabadi S, Imani H et al (2016) A comparison of the chemical composition of flowering shoot Thymus kotschyanus and Thymus vulgaris by using GC-mass and antimicrobial effects of the Bacteria Staphylococcus aureus and Pseudomonas aeruginosa. J Essent Oil Bear Plants 19:1639–1647
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Emami Bistgani, Z., Mamedov, N., Lotfy Ashour, M. (2022). Genus Thymus in Iran—Ethnobotany, Phytochemical, Molecular, and Pharmacological Features. In: Öztürk, M., Khan, S.M., Altay, V., Efe, R., Egamberdieva, D., Khassanov, F.O. (eds) Biodiversity, Conservation and Sustainability in Asia. Springer, Cham. https://doi.org/10.1007/978-3-030-73943-0_45
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