Abstract
The choroid plexus form cerebrospinal fluid (CSF) within four ventricles the brain. The composition of CSF is very similar to the of the brain’s extracellular, and its composition depends on filtration and diffusion from the blood. Few conditions cause CSF volume and pressure to fall below normal (dehydration may be one), but many conditions can cause it to increase, sometimes under pressure. This may lead to blocked flow CSF from one or more ventricles, which causes an increase in intracranial pressure, and CSF buildup i.e. to hydrocephalus. Hydrocephalus results from one of three possible causes: over secretion of CSF, impaired absorption of CSF or obstruction of CSF pathways. The concentration of metabolites of the monoamines homovanillic acid (HVA) and 5-hydrocephalus acetic acid (5-HIAA) were determined with HPLC-ED in the CSF of 17 patients (children of 1 age) with hydrocephalus. Determined 5-HIAA concentrations are in the range of 0,99–113,89 ng/mL and HVA 0,98–165,92 ng/mL in CSF due to pressure changes occurring in hydrocephalus is increasing the turnover of serotonin and dopamine to its metabolites. The correlation no could be established between the levels of 5-HIAA and HVA and type of hydrocephalus, and the duration of disease.
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References
Sasaki, T., Fukushima, T., Ohishi, M., Toyo´oka, T.: Development of 6-hydroxychroman-based derivatization reagent: application to the analysis of 5-hydrxytryptamine and catecholamines by using high-performance liquid chromatography with electrochemical detection. Biomed. Chromatogr. 22, 888–899 (2008)
Meltzer, H.Y., Arora, R.C.: Platelet serotonin studies in affective disorders: evidence for serotogenic abnormality. U: 5-Hydroxytryptamine in Psychiatry, A Spectrum of Ideas, Oxford University Press, pp. 50–89 (1991)
Hoyer, D., Clarke, D.E., Fozard, J.R., Hartig, P.R., Martin, G.R., Mylecharane, E.J., Humphrey, P.P.: International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin). Pharmacol. Rev. 46(2), 157–203 (1994)
Sofić, E.: Metabolic turnover of biogenic amines in physiological fluids: diagnostic significances. Turk. J. Biochem. 32(3), 120–129 (2007)
Salihović, M., Sofić, E.: 5-HIAA and HVA in the coma cerebri, hydrocephalus and tumor cerebri. In: CMBEBIH 2017, pp. 396–401. Springer, Singapore (2017)
Nordström, P., Samuelsson, M., Åsberg, M., Träskman-Bendz, L., Åberg-Wistedt, A., Nordin, C., Bertilsson, L.: CSF 5-HIAA predicts suicide risk after attempted suicide. Suicide Life-Threat. Behav. 24(1), 1–9 (1994)
Klarica, M.: Uloga osmolarnosti likvora u patofiziologiji intrakronijalnog tlaka. Disertacija, Medicinski fakultet Sveučilišta u Zagrebu, Zagreb (1992)
Juretic, A., Spagnoli, G.C., Schultz-Thater, E., Sarcevic, B.: Cancer/testis tumour-associated antigens: immunohistochemical detection with monoclonal antibodies. Lancet Oncol. 4(2), 104–109 (2003)
Relkin, N., Marmarou, A., Klinge, P., Bergsneider, M., Black, P.M.: Diagnosing idiopathic normal-pressure hydrocephalus. Neurosurgery 57(suppl_3), S2–S4 (2005)
Lionetto, L., Lostia, A.M., Stigliano, A., Cardelli, P., Simmaco, M.: HPLC-mass spectrometry method for quantitative detection of neuroendocrine tumor markers: Vanillylmandelic acid, homovanillic acid and 5-hydroxyindolacetic acid. Clin. Chim. Acta 398, 1–4 (2008)
Sherman, J.L., Citrin, C.M.: Magnetic resonance demonstration of normal CSF flow. Am. J. Neuroradiol. 7(1), 3–6 (1986)
Saunders, N.R., Habgood, M.D., Dziegielewska, K.M.: Barrier mechanisms in the brain, I. Adult brain. Clin. Exp. Pharmacol. Physiol. 26(1), 11–29 (1999)
Ramirez-Bermudez, J., Ruiz-Chow, A., Perez-Neri, I., Soto-Hernandez, J.L., Flores-Hernandez, R., Nente, F., Montes, S., Rios, C.: Cerebrospinal fluid homovanillic acid is correlated to psychotic features in neurological patients with delirium. General Hosp. Psychiatry 30, 337–343 (2008)
Csernansky, J.G., Wrona, C.T., Bardgett, M.E., Early, T.S., Newcomer, J.W.: Subcortical dopamine and serotonin turnover during acute and subchronic administration of typical and atypical neuroleptics. Psychopharmacol. 110(1–2), 145–151 (1993)
Sperk, G.: Simultaneus determination of serotonin, 5-hidroxyindoleacetic acid, 3, 4-dihydroxyphenylacetic acid and homovanillic acid by hight performance liquid chromatography with electrochemical detection. J. Neurochem. 38, 840–843 (1982)
Csernansky, J.G., King, R.J., Faustman, W.O., Moses, J.A., Poscher, M.E., Faull, K.F.: 5-HIAA in cerebrospinal fluid and deficit schizophrenic characteristics. Br. J. Psychiatry 156, 501–507 (1990)
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Salihović, M., Sofić, E. (2021). Hydrocephalus: 5-HIAA and HVA in the Cerebrospinal Fluid. In: Badnjevic, A., Gurbeta Pokvić, L. (eds) CMBEBIH 2021. CMBEBIH 2021. IFMBE Proceedings, vol 84. Springer, Cham. https://doi.org/10.1007/978-3-030-73909-6_46
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DOI: https://doi.org/10.1007/978-3-030-73909-6_46
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