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Regulation of Tumor Suppressor Par-4 by Ceramide

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Tumor Suppressor Par-4

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Abstract

Prostate apoptosis response-4 (Par-4) is a pro-apoptotic protein that selectively induces apoptosis in cancer cells, thereby exerting prominent tumor-suppressing functions. Ceramides are important bioactive lipids belonging to the sphingolipid family. Both Par-4 and ceramide are critical regulators of cellular responses to acute stressors and has been clearly established as a key player in the execution of cell death. Though Par-4 and ceramide act as an apparent collaborator of cell-fate decisions, the relationship between these molecules is very complex, and mechanisms underlying their regulation are diverse and not fully characterized. In this chapter, we portray the role and mechanisms of action of Par-4 and ceramide in apoptosis and autophagy. Specifically, we are elaborating on the central role of Par-4 in ceramide-induced cell death signaling. Understanding the Par-4-ceramide connection will not only have profound importance to the understanding of programmed cell death pathways, but also will have an impact on interventions of cancer therapy and prevention.

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Acknowledgments

The authors thank the members of the Sehamuddin Galadari laboratory for their helpful discussions. The authors apologize to those investigators whose publications were not mentioned in this review due to space limitations. This work is supported by Al Jalila Foundation for Medical Research grant RA 234 (AJF201631) and New York University Abu Dhabi Research grant AD 252.

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  1. Cell Death Signaling Laboratory, Division of Science (Biology), Experimental Research Building, New York University Abu Dhabi, Abu Dhabi, UAE

    Sehamuddin Galadari, Anees Rahman Cheratta & Faisal Thayyullathil

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  1. Sehamuddin Galadari
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Correspondence to Sehamuddin Galadari .

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  1. Associate Director, Markey Cancer Center, University of Kentucky, Lexington, KY, USA

    Vivek M. Rangnekar

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Galadari, S., Cheratta, A.R., Thayyullathil, F. (2022). Regulation of Tumor Suppressor Par-4 by Ceramide. In: Rangnekar, V.M. (eds) Tumor Suppressor Par-4. Springer, Cham. https://doi.org/10.1007/978-3-030-73572-2_10

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