Skip to main content

Pathomechanisms of Drug-Induced Neurological Disorders

  • Chapter
  • First Online:

Abstract

The pharmacologically mediated mechanism is defined as the interaction of the drug with its intended target or relevant receptor, which can result in an anticipated biological effect or in a previously unanticipated adverse effect. An understanding of the pathomechanism of drug-induced neurologic disorders may be useful for treating these complications.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   249.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  • Campo C, da Silva Filho MI, Weinhold N, et al. Bortezomib-induced peripheral neuropathy: a genome-wide association study on multiple myeloma patients. Hematol Oncol. 2018;36:232–7.

    Article  CAS  Google Scholar 

  • Cohen J, D'Agostino L, Wilson J, Tuzer F, Torres C. Astrocyte senescence and metabolic changes in response to HIV antiretroviral therapy drugs. Front Aging Neurosci. 2017;9:281.

    Article  Google Scholar 

  • Csoka AB, Szyf M. Epigenetic side-effects of common pharmaceuticals: a potential new field in medicine and pharmacology. Med Hypotheses. 2009;73:770–80.

    Article  CAS  Google Scholar 

  • Desai R, Frazier AE, Durigon R, et al. ATAD3 gene cluster deletions cause cerebellar dysfunction associated with altered mitochondrial DNA and cholesterol metabolism. Brain. 2017;140:1595–610.

    Article  Google Scholar 

  • El-Okdi NS, Lumbrezer D, Karanovic D, et al. Serotonin syndrome after the use of tramadol and ziprasidone in a patient with a deep brain stimulator for Parkinson disease. Am J Ther. 2014;21(4):e97–9.

    Article  Google Scholar 

  • Feng X, Chen A, Zhang Y, et al. Central nervous system toxicity of metallic nanoparticles. Int J Nanomedicine. 2015;10:4321–40.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Häuser W, Sarzi-Puttini P, Tölle TR, Wolfe F. Placebo and nocebo responses in randomised controlled trials of drugs applying for approval for fibromyalgia syndrome treatment: systematic review and meta-analysis. Clin Exp Rheumatol. 2012;30(6 Suppl 74):78–87.

    PubMed  Google Scholar 

  • Jain KK. Use of diazepam in carotid angiography. Can J Neurosci. 1974;1:141–2.

    CAS  Google Scholar 

  • Jain KK. Applications of AmpliChip CYP450. Mol Diagn. 2005;9:119–27.

    PubMed  Google Scholar 

  • Jain KK. Molecular Diagnostics. Basel: Jain PharmaBiotech Publications; 2021.

    Google Scholar 

  • McWhinney SR, Goldberg RM, McLeod HL. Platinum neurotoxicity pharmacogenetics. Mol Cancer Ther. 2009;8:10–6.

    Article  CAS  Google Scholar 

  • Michiue T, Ishikawa T, Quan L, et al. Single-stranded DNA as an immunohistochemical marker of neuronal damage in human brain: an analysis of autopsy material with regard to the cause of death. Forensic Sci Int. 2008;178:185–91.

    Article  CAS  Google Scholar 

  • Ruiz-Roso G, Gomis A, Fernández-Lucas M, et al. Aciclovir and valaciclovir neurotoxicity in patients with renal failure. Nefrologia. 2012;32:114–5.

    PubMed  Google Scholar 

  • Rusyniak DE. Neurologic manifestations of chronic methamphetamine abuse. Neurol Clin. 2011;29:641–55.

    Article  Google Scholar 

  • Yamamoto BK, Moszczynska A, Gudelsky GA. Amphetamine toxicities: classical and emerging mechanisms. Ann N Y Acad Sci. 2010;1187:101–21.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Kewal K. Jain .

Rights and permissions

Reprints and permissions

Copyright information

© 2021 The Author(s), under exclusive license to Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Jain, K.K. (2021). Pathomechanisms of Drug-Induced Neurological Disorders. In: Drug-induced Neurological Disorders. Springer, Cham. https://doi.org/10.1007/978-3-030-73503-6_4

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-73503-6_4

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-73502-9

  • Online ISBN: 978-3-030-73503-6

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics