Skip to main content

Extra-cardiac Doppler Hemodynamic Assessment Using Point-of-Care Ultrasound

  • Chapter
  • First Online:
Cardiopulmonary Monitoring

Abstract

Ultrasound imaging is now integrated in most intensive care units. Beyond its use as an adjunct for rapid diagnosis and to guide procedures, Point-of-Care Doppler ultrasound might offer the opportunity to gain unique insight into the physiology and hemodynamic status of the critically ill patient. This chapter focuses on understanding the basic principles underlying the analysis of arterial and venous Doppler signals and on the possible interpretation of abnormal waveforms according to the clinical context.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 149.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 199.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 279.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Abbreviations

A:

vessel cross-sectional area

ICU:

intensive care unit

CVP:

central venous pressure

ICU:

intensive care unit

IVC:

inferior vena cava

POCUS:

 point-of-care ultrasound

Q:

blood flow

∆P:

pressure difference

PF:

pulsatility fraction

PI:

pulsatility index

R:

resistance

RI:

resistive index

V:

velocity

TVI:

time-velocity integral

Ao:

aorta

AR:

atrial reversal

CI:

confidence interval

CO:

cardiac output

CPB:

cardiopulmonary bypass

d :

diameter

D:

diastolic

DAP:

diastolic arterial pressure

ECA:

external carotid artery

EDV:

end-diastolic velocity

HITS:

high intensity transient signals

HR:

heart rate

HV:

hepatic vein

IABP:

intra-aortic counterpulsation balloon pump

HR:

hazard ratio

ICA:

internal carotid artery

ICU:

intensive care unit

IVC:

inferior vena cava

LA:

left atrium

LV:

left ventricle

LVOT:

left ventricular outflow tract

MPA:

main pulmonary artery

MV:

mean velocity

PDV:

peak systolic velocity

PF:

pulsatility fraction

P fa :

femoral arterial pressure

P ms :

mean systemic venous pressure

P ra :

radial arterial pressure

P ra :

right atrial pressure

P IC :

intra-capsular renal pressure

P pa :

pulmonary artery pressure

Rvr:

resistance to venous return

RA:

right atrium

RI:

resistance index

RPA:

right pulmonary artery

RV:

right ventricle

S:

systolic

SaO2:

oxygen saturation

SAP:

systolic arterial pressure

SVC:

superior vena cava

V :

velocity

V d :

diastolic velocity

V m :

mean velocity

V max :

maximal velocity during the cardiac cycle

V min :

minimal velocity during the cardiac cycle

V s :

systolic velocity

VTI:

velocity-time integral

References

  • Abu-Yousef MM, Milam SG, Farner RM. Pulsatile portal vein flow: a sign of tricuspid regurgitation on duplex Doppler sonography. AJR Am J Roentgenol. 1990;155(4):785–8.

    Article  CAS  PubMed  Google Scholar 

  • Adamson SL. Arterial pressure, vascular input impedance, and resistance as determinants of pulsatile blood flow in the umbilical artery. Eur J Obstet Gynecol Reprod Biol. 1999;84(2):119–25.

    Article  CAS  PubMed  Google Scholar 

  • Araújo NC, Suassuna JHR. Reversed diastolic flow in page kidney following native kidney biopsy. J Diagn Med Sonography. 2016;32(6):371–4.

    Article  Google Scholar 

  • Barjaktarevic I, Toppen WE, Hu S, Aquije Montoya E, Ong S, Buhr R, et al. Ultrasound assessment of the change in carotid corrected flow time in fluid responsiveness in undifferentiated shock. Crit Care Med. 2018;46(11):e1040–e6.

    Article  PubMed  PubMed Central  Google Scholar 

  • Beaubien-Souligny W, Denault AY. Real-time assessment of renal venous flow by transesophageal echography during cardiac surgery. A&A Pract. 2018;12:30.

    Article  Google Scholar 

  • Beaubien-Souligny W, Huard G, Bouchard J, Lamarche Y, Denault A, Albert M. Doppler renal resistance index for the prediction of response to passive leg-raising following cardiac surgery. J Clin Ultrasound. 2018a;46:455.

    Article  PubMed  Google Scholar 

  • Beaubien-Souligny W, Benkreira A, Robillard P, Bouabdallaoui N, Chasse M, Desjardins G, et al. Alterations in portal vein flow and intrarenal venous flow are associated with acute kidney injury after cardiac surgery: a prospective observational cohort study. J Am Heart Assoc. 2018b;7(19):e009961.

    Article  PubMed  PubMed Central  Google Scholar 

  • Benkreira A, Beaubien-Souligny W, Mailhot T, Bouabdallaoui N, Robillard P, Desjardins G, et al. Portal hypertension is associated with congestive encephalopathy and delirium after cardiac surgery. Can J Cardiol. 2019; (In Press).

    Google Scholar 

  • Boddi M, Sacchi S, Lammel RM, Mohseni R, Serneri GG. Age-related and vasomotor stimuli-induced changes in renal vascular resistance detected by Doppler ultrasound. Am J Hypertens. 1996;9(5):461–6.

    Article  CAS  PubMed  Google Scholar 

  • Bossard G, Bourgoin P, Corbeau JJ, Huntzinger J, Beydon L. Early detection of postoperative acute kidney injury by Doppler renal resistive index in cardiac surgery with cardiopulmonary bypass. Br J Anaesth. 2011;107(6):891–8.

    Article  CAS  PubMed  Google Scholar 

  • Bude RO, DiPietro MA, Platt JF, Rubin JM. Effect of furosemide and intravenous normal saline fluid load upon the renal resistive index in nonobstructed kidneys in children. J Urol. 1994;151(2):438–41.

    Article  CAS  PubMed  Google Scholar 

  • Catalano D, Caruso G, DiFazzio S, Carpinteri G, Scalisi N, Trovato GM. Portal vein pulsatility ratio and heart failure. J Clin Ultrasound. 1998;26(1):27–31.

    Article  CAS  PubMed  Google Scholar 

  • Chavhan GB, Parra DA, Mann A, Navarro OM. Normal Doppler spectral waveforms of major pediatric vessels: specific patterns. Radiographics. 2008;28(3):691–706.

    Article  PubMed  Google Scholar 

  • Conger JD, Robinette JB, Hammond WS. Differences in vascular reactivity in models of ischemic acute renal failure. Kidney Int. 1991;39(6):1087–97.

    Article  CAS  PubMed  Google Scholar 

  • Darmon M, Schortgen F, Vargas F, Liazydi A, Schlemmer B, Brun-Buisson C, et al. Diagnostic accuracy of Doppler renal resistive index for reversibility of acute kidney injury in critically ill patients. Intensive Care Med. 2011;37(1):68–76.

    Article  PubMed  Google Scholar 

  • De Backer D, Creteur J, Preiser JC, Dubois MJ, Vincent JL. Microvascular blood flow is altered in patients with sepsis. Am J Respir Crit Care Med. 2002;166(1):98–104.

    Article  PubMed  Google Scholar 

  • De Backer D, Orbegozo Cortes D, Donadello K, Vincent JL. Pathophysiology of microcirculatory dysfunction and the pathogenesis of septic shock. Virulence. 2014;5(1):73–9.

    Article  PubMed  Google Scholar 

  • Denault A, Lamarche Y, Rochon A, Cogan J, Liszkowski M, Lebon JS, et al. Innovative approaches in the perioperative care of the cardiac surgical patient in the operating room and intensive care unit. Can J Cardiol. 2014a;30(12 Suppl):S459–77.

    Article  PubMed  Google Scholar 

  • Denault A, Vegas A, Royse C. Bedside clinical and ultrasound-based approaches to the management of hemodynamic instability--part I: focus on the clinical approach: continuing professional development. Can J Anaesth. 2014b;61(9):843–64.

    Article  PubMed  Google Scholar 

  • Denault AYCP, Lamarche Y, Tardif JC, Vegas A. Basic transesophageal and critical care ultrasound. CRC Press; 2017.

    Book  Google Scholar 

  • Deruddre S, Cheisson G, Mazoit JX, Vicaut E, Benhamou D, Duranteau J. Renal arterial resistance in septic shock: effects of increasing mean arterial pressure with norepinephrine on the renal resistive index assessed with Doppler ultrasonography. Intensive Care Med. 2007;33(9):1557–62.

    Article  PubMed  Google Scholar 

  • Ducrocq X, Braun M, Debouverie M, Junges C, Hummer M, Vespignani H. Brain death and transcranial Doppler: experience in 130 cases of brain dead patients. J Neurol Sci. 1998a;160(1):41–6.

    Article  CAS  PubMed  Google Scholar 

  • Ducrocq X, Hassler W, Moritake K, Newell DW, von Reutern GM, Shiogai T, et al. Consensus opinion on diagnosis of cerebral circulatory arrest using Doppler-sonography: Task Force Group on cerebral death of the Neurosonology Research Group of the World Federation of Neurology. J Neurol Sci. 1998b;159(2):145–50.

    Article  CAS  PubMed  Google Scholar 

  • Eljaiek R, Cavayas YA, Rodrigue E, Desjardins G, Lamarche Y, Toupin F, et al. High postoperative portal venous flow pulsatility indicates right ventricular dysfunction and predicts complications in cardiac surgery patients. Br J Anaesth. 2019;122(2):206–14.

    Article  CAS  PubMed  Google Scholar 

  • Gallix BP, Taourel P, Dauzat M, Bruel JM, Lafortune M. Flow pulsatility in the portal venous system: a study of Doppler sonography in healthy adults. AJR Am J Roentgenol. 1997;169(1):141–4.

    Article  CAS  PubMed  Google Scholar 

  • Godfrey GE, Dubrey SW, Handy JM. A prospective observational study of stroke volume responsiveness to a passive leg raise manoeuvre in healthy non-starved volunteers as assessed by transthoracic echocardiography. Anaesthesia. 2014;69(4):306–13.

    Article  CAS  PubMed  Google Scholar 

  • Grun OS, Herath E, Weihrauch A, Flugge F, Rogacev KS, Fliser D, et al. Does the measurement of the difference of resistive indexes in spleen and kidney allow a selective assessment of chronic kidney injury? Radiology. 2012;264(3):894–902.

    Article  PubMed  Google Scholar 

  • Guinot PG, Bernard E, Abou Arab O, Badoux L, Diouf M, Zogheib E, et al. Doppler-based renal resistive index can assess progression of acute kidney injury in patients undergoing cardiac surgery. J Cardiothorac Vasc Anesth. 2013;27(5):890–6.

    Article  PubMed  Google Scholar 

  • Guyton AC, Lindsey AW, Abernathy B, Richardson T. Venous return at various right atrial pressures and the normal venous return curve. Am J Phys. 1957;189(3):609–15.

    Article  CAS  Google Scholar 

  • Hassler W, Steinmetz H, Pirschel J. Transcranial Doppler study of intracranial circulatory arrest. J Neurosurg. 1989;71(2):195–201.

    Article  CAS  PubMed  Google Scholar 

  • Huguet R, Fard D, d’Humieres T, Brault-Meslin O, Faivre L, Nahory L, et al. Three-dimensional inferior vena cava for assessing central venous pressure in patients with cardiogenic shock. J Am Soc Echocardiogr. 2018;31:1034.

    Article  PubMed  Google Scholar 

  • Hulin J, Aslanian P, Desjardins G, Belaidi M, Denault A. The critical importance of hepatic venous blood flow Doppler assessment for patients in shock. A & A Case Rep. 2016;6(5):114–20.

    Article  Google Scholar 

  • Iida N, Seo Y, Sai S, Machino-Ohtsuka T, Yamamoto M, Ishizu T, et al. Clinical implications of intrarenal hemodynamic evaluation by Doppler ultrasonography in heart failure. JACC Heart Fail. 2016;4(8):674–82.

    Article  PubMed  Google Scholar 

  • Ikeda Y, Ishii S, Yazaki M, Fujita T, Iida Y, Kaida T, et al. Portal congestion and intestinal edema in hospitalized patients with heart failure. Heart Vessel. 2018;33(7):740–51.

    Article  Google Scholar 

  • Jalil B, Thompson P, Cavallazzi R, Marik P, Mann J, El-Kersh K, et al. Comparing changes in carotid flow time and stroke volume induced by passive leg raising. Am J Med Sci. 2018;355(2):168–73.

    Article  PubMed  Google Scholar 

  • Kimchi A, Ellrodt AG, Berman DS, Riedinger MS, Swan HJ, Murata GH. Right ventricular performance in septic shock: a combined radionuclide and hemodynamic study. J Am Coll Cardiol. 1984;4(5):945–51.

    Article  CAS  PubMed  Google Scholar 

  • Ko EY, Kim TK, Kim PN, Kim AY, Ha HK, Lee MG. Hepatic vein stenosis after living donor liver transplantation: evaluation with Doppler US. Radiology. 2003;229(3):806–10.

    Article  PubMed  Google Scholar 

  • Lahmer T, Rasch S, Schnappauf C, Schmid RM, Huber W. Influence of volume administration on Doppler-based renal resistive index, renal hemodynamics and renal function in medical intensive care unit patients with septic-induced acute kidney injury: a pilot study. Int Urol Nephrol. 2016;48(8):1327–34.

    Article  PubMed  Google Scholar 

  • Langenberg C, Bellomo R, May C, Wan L, Egi M, Morgera S. Renal blood flow in sepsis. Crit Care. 2005;9(4):R363–74.

    Article  PubMed  PubMed Central  Google Scholar 

  • Langenberg C, Wan L, Egi M, May CN, Bellomo R. Renal blood flow in experimental septic acute renal failure. Kidney Int. 2006;69(11):1996–2002.

    Article  CAS  PubMed  Google Scholar 

  • Lelubre C, Vincent JL. Mechanisms and treatment of organ failure in sepsis. Nat Rev Nephrol. 2018;14(7):417–27.

    Article  PubMed  Google Scholar 

  • Lockhart ME, Wells CG, Morgan DE, Fineberg NS, Robbin ML. Reversed diastolic flow in the renal transplant: perioperative implications versus transplants older than 1 month. AJR Am J Roentgenol. 2008;190(3):650–5.

    Article  PubMed  Google Scholar 

  • Marik PE, Lemson J. Fluid responsiveness: an evolution of our understanding. Br J Anaesth. 2014;112(4):617–20.

    Article  CAS  PubMed  Google Scholar 

  • McNaughton DA, Abu-Yousef MM. Doppler US of the liver made simple. Radiographics. 2011;31(1):161–88.

    Article  PubMed  Google Scholar 

  • Moussa MD, Scolletta S, Fagnoul D, Pasquier P, Brasseur A, Taccone FS, et al. Effects of fluid administration on renal perfusion in critically ill patients. Crit Care. 2015;19:250.

    Article  PubMed  PubMed Central  Google Scholar 

  • Nagueh SF, Kopelen HA, Zoghbi WA. Relation of mean right atrial pressure to echocardiographic and Doppler parameters of right atrial and right ventricular function. Circulation. 1996;93(6):1160–9.

    Article  CAS  PubMed  Google Scholar 

  • Narula J, Chandrashekhar Y, Braunwald E. Time to add a fifth pillar to bedside physical examination: inspection, palpation, percussion, auscultation, and insonation. JAMA Cardiol. 2018;3(4):346–50.

    Article  PubMed  Google Scholar 

  • Nijst P, Martens P, Dupont M, Tang WHW, Mullens W. Intrarenal flow alterations during transition from euvolemia to intravascular volume expansion in heart failure patients. JACC Heart Fail. 2017;5(9):672–81.

    Article  PubMed  Google Scholar 

  • Ninet S, Schnell D, Dewitte A, Zeni F, Meziani F, Darmon M. Doppler-based renal resistive index for prediction of renal dysfunction reversibility: a systematic review and meta-analysis. J Crit Care. 2015;30(3):629–35.

    Article  PubMed  Google Scholar 

  • Parker MM, McCarthy KE, Ognibene FP, Parrillo JE. Right ventricular dysfunction and dilatation, similar to left ventricular changes, characterize the cardiac depression of septic shock in humans. Chest. 1990;97(1):126–31.

    Article  CAS  PubMed  Google Scholar 

  • Platt JF, Rubin JM, Ellis JH. Acute renal failure: possible role of duplex Doppler US in distinction between acute prerenal failure and acute tubular necrosis. Radiology. 1991;179(2):419–23.

    Article  CAS  PubMed  Google Scholar 

  • Prowle JR, Echeverri JE, Ligabo EV, Ronco C, Bellomo R. Fluid balance and acute kidney injury. Nat Rev Nephrol. 2010;6(2):107–15.

    Article  PubMed  Google Scholar 

  • Pulido JN, Afessa B, Masaki M, Yuasa T, Gillespie S, Herasevich V, et al. Clinical spectrum, frequency, and significance of myocardial dysfunction in severe sepsis and septic shock. Mayo Clin Proc. 2012;87(7):620–8.

    Article  PubMed  PubMed Central  Google Scholar 

  • Rengo C, Brevetti G, Sorrentino G, D’Amato T, Imparato M, Vitale DF, et al. Portal vein pulsatility ratio provides a measure of right heart function in chronic heart failure. Ultrasound Med Biol. 1998;24(3):327–32.

    Article  CAS  PubMed  Google Scholar 

  • Ricci P, Cantisani V, Lombardi V, Alfano G, D’Ambrosio U, Menichini G, et al. Is color-Doppler US a reliable method in the follow-up of transjugular intrahepatic portosystemic shunt (TIPS)? J Ultrasound. 2007;10(1):22–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Rudski LG, Lai WW, Afilalo J, Hua L, Handschumacher MD, Chandrasekaran K, et al. Guidelines for the echocardiographic assessment of the right heart in adults: a report from the American Society of Echocardiography endorsed by the European Association of Echocardiography, a registered branch of the European Society of Cardiology, and the Canadian Society of Echocardiography. J Am Soc Echocardiogr. 2010;23(7):685–713; quiz 86–8

    Article  PubMed  Google Scholar 

  • Schnell D, Camous L, Guyomarc’h S, Duranteau J, Canet E, Gery P, et al. Renal perfusion assessment by renal Doppler during fluid challenge in sepsis. Crit Care Med. 2013;41(5):1214–20.

    Article  PubMed  Google Scholar 

  • Sidor M, Premachandra L, Hanna B, Nair N, Misra A. Carotid flow as a surrogate for cardiac output measurement in hemodynamically stable participants. J Intensive Care Med. 2018:885066618775694.

    Google Scholar 

  • Styczynski G, Milewska A, Marczewska M, Sobieraj P, Sobczynska M, Dabrowski M, et al. Echocardiographic correlates of abnormal liver tests in patients with exacerbation of chronic heart failure. J Am Soc Echocardiogr. 2016;29(2):132–9.

    Article  PubMed  Google Scholar 

  • Sutton TA, Fisher CJ, Molitoris BA. Microvascular endothelial injury and dysfunction during ischemic acute renal failure. Kidney Int. 2002;62(5):1539–49.

    Article  CAS  PubMed  Google Scholar 

  • Tang WH, Kitai T. Intrarenal venous flow: a window into the congestive kidney failure phenotype of heart failure? JACC Heart Fail. 2016;4(8):683–6.

    Article  PubMed  Google Scholar 

  • Toupin F, Denault A, Lamarche Y, Deschamps A. Hemodynamic instability and fluid responsiveness. Can J Anaesth. 2013;60(12):1240–7.

    Article  PubMed  Google Scholar 

  • Vallabhajosyula S, Kumar M, Pandompatam G, Sakhuja A, Kashyap R, Kashani K, et al. Prognostic impact of isolated right ventricular dysfunction in sepsis and septic shock: an 8-year historical cohort study. Ann Intensive Care. 2017;7(1):94.

    Article  PubMed  PubMed Central  Google Scholar 

  • Vegas A, Denault A, Royse C. A bedside clinical and ultrasound-based approach to hemodynamic instability – part II: bedside ultrasound in hemodynamic shock: continuing professional development. Can J Anaesth. 2014;61(11):1008–27.

    Article  PubMed  Google Scholar 

  • Vieillard-Baron A, Augarde R, Prin S, Page B, Beauchet A, Jardin F. Influence of superior vena caval zone condition on cyclic changes in right ventricular outflow during respiratory support. Anesthesiology. 2001;95(5):1083–8.

    Article  CAS  PubMed  Google Scholar 

  • Vlachopoulos C, O’Rourke M, Nichols WW. McDonald’s blood flow in arteries: theoretical, experimental and clinical principles. CRC Press; 2011.

    Book  Google Scholar 

  • Wan L, Yang N, Hiew CY, Schelleman A, Johnson L, May C, et al. An assessment of the accuracy of renal blood flow estimation by Doppler ultrasound. Intensive Care Med. 2008;34(8):1503–10.

    Article  PubMed  Google Scholar 

  • Wardhan R, Shelley K. Peripheral venous pressure waveform. Curr Opin Anaesthesiol. 2009;22(6):814–21.

    Article  PubMed  Google Scholar 

  • Woodcock TE, Woodcock TM. Revised Starling equation and the glycocalyx model of transvascular fluid exchange: an improved paradigm for prescribing intravenous fluid therapy. Br J Anaesth. 2012;108(3):384–94.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2021 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Beaubien-Souligny, W., Denault, A. (2021). Extra-cardiac Doppler Hemodynamic Assessment Using Point-of-Care Ultrasound. In: Magder, S., Malhotra, A., Hibbert, K.A., Hardin, C.C. (eds) Cardiopulmonary Monitoring. Springer, Cham. https://doi.org/10.1007/978-3-030-73387-2_26

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-73387-2_26

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-73386-5

  • Online ISBN: 978-3-030-73387-2

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics