Abstract
Receptors play important roles in the recognition, transportation and mediation of immunoglobulins. The Fc receptors on the cell surface bind to the constant region (Fc) of the Ig and modulate the immune response. In avian species, three receptors for IgY have been discovered: IgY’s Fc receptor (FcRY), Chicken like Ig-like receptor AB1 (CHIR-AB1), and Gallus gallus receptor (ggFcR). FcRY, despite being considered as a functional homologue of the neonatal Fc receptor (FcRn) in mammals belongs to a different protein structural family (mannose family). CHIR-AB1 functions as a classical FcR expressed on chicken B cells, macrophages, monocytes and NK cells. ggFcR is found highly expressed in peripheral blood mononuclear cells. The transfer of IgY from the hen to the embryo is a two-step receptor mediated process: the transfer from the maternal bloodstream to the yolk sac; and secondly from the yolk sac to the embryo. FcRY mainly functions in the second process, while the receptor involved in the initial step, as well as the functions of CHIR-AB1 and ggFcR, remain largely unknown. A deeper understanding of IgY’s receptors is crucial to a full understanding IgY’s transportation, particularly in the unique process of “hen-egg-offspring”, which is quite different to mammals. Knowledge of the receptors can also clarify the evolution of immunoglobulins and is important in the development of transgenic hens which could express complex human proteins.
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Change history
16 September 2021
The original version of the book was inadvertently published with only one of the three affiliations of the volume editor and chapter author Xiao-Ying Zhang.
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Zhang, X., Ge, S., Morgan, P.M. (2021). IgY Cell Receptors and Immunity Transfer. In: Zhang, XY., Vieira-Pires, R.S., Morgan, P.M., Schade, R. (eds) IgY-Technology: Production and Application of Egg Yolk Antibodies. Springer, Cham. https://doi.org/10.1007/978-3-030-72688-1_6
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DOI: https://doi.org/10.1007/978-3-030-72688-1_6
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