Abstract
Segmentation of Glioma from three dimensional magnetic resonance imaging (MRI) is useful for diagnosis and surgical treatment of patients with brain tumor. Manual segmentation is expensive, requiring medical specialists. In the recent years, the Brain Tumor Segmentation Challenge (BraTS) has been calling researchers to submit automated glioma segmentation and survival prediction methods for evaluation and discussion over their public, multimodality MRI dataset, with manual annotations. This work presents an exploration of different solutions to the problem, using 3D UNets and self attention for multitasking both predictions and also training (2D) EfficientDet derived segmentations, with the best results submitted for the official challenge leaderboard. We show that end-to-end multitasking survival and segmentation, in this case, led to better results.
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References
Bakas, S., et al.: Segmentation labels and radiomic features for the pre-operative scans of the TCGA-LGG collection. The cancer imaging archive 286 (2017)
Bakas, S., et al.: Segmentation labels and radiomic features for the pre-operative scans of the TCGA-GBM collection. The cancer imaging archive. Nat. Sci .Data 4, 170117 (2017)
Bakas, S., et al.: Advancing the cancer genome atlas glioma MRI collections with expert segmentation labels and radiomic features. Sci. Data 4, 170117 (2017)
Bakas, S., et al.: Identifying the best machine learning algorithms for brain tumor segmentation, progression assessment, and overall survival prediction in the brats challenge. arXiv preprint arXiv:1811.02629 (2018)
Carmo, D., Silva, B., Yasuda, C., Rittner, L., Lotufo, R.: Hippocampus Segmentation on Epilepsy and Alzheimer’s Disease Studies with Multiple Convolutional Neural Networks. arXiv:2001.05058 [cs, eess], January 2020
Chollet, F.: Xception: deep learning with depthwise separable convolutions. In: Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, pp. 1251–1258 (2017)
Górriz, M., Antony, J., McGuinness, K., Giró-i Nieto, X., O’Connor, N.E.: Assessing Knee OA Severity with CNN attention-based end-to-end architectures. arXiv:1908.08856 [cs, eess], August 2019
Isensee, F., Kickingereder, P., Wick, W., Bendszus, M., Maier-Hein, K.H.: Brain Tumor Segmentation and Radiomics Survival Prediction: Contribution to the BRATS 2017 Challenge. arXiv:1802.10508 [cs], February 2018
Isensee, F., et al. (eds.): Brainlesion: Glioma, Multiple Sclerosis, Stroke and Traumatic Brain Injuries, pp. 234–244. Lecture Notes in Computer Science, Springer International Publishing, Cham (2019). https://doi.org/10.1007/978-3-030-11726-9_21
Jiang, Z., Ding, C., Liu, M., Tao, D.: Two-stage cascaded U-Net: 1st place solution to BraTS challenge 2019 segmentation task. In: Crimi, A., Bakas, S. (eds.) BrainLes 2019. LNCS, vol. 11992, pp. 231–241. Springer, Cham (2020). https://doi.org/10.1007/978-3-030-46640-4_22
Liu, L., et al.: On the Variance of the Adaptive Learning Rate and Beyond. arXiv:1908.03265 [cs, stat], April 2020
Menze, B.H., et al.: The multimodal brain tumor image segmentation benchmark (brats). IEEE Trans. Med. Imaging 34(10), 1993–2024 (2014)
Myronenko, A.: 3D MRI brain tumor segmentation using autoencoder regularization. In: Crimi, A., Bakas, S., Kuijf, H., Keyvan, F., Reyes, M., van Walsum, T. (eds.) BrainLes 2018. LNCS, vol. 11384, pp. 311–320. Springer, Cham (2019). https://doi.org/10.1007/978-3-030-11726-9_28
Myronenko, A., Hatamizadeh, A.: Robust semantic segmentation of brain tumor regions from 3D MRIs. In: Crimi, A., Bakas, S. (eds.) BrainLes 2019. LNCS, vol. 11993, pp. 82–89. Springer, Cham (2020). https://doi.org/10.1007/978-3-030-46643-5_8
Ramachandran, P., Zoph, B., Le, Q.V.: Searching for activation functions. arXiv preprint arXiv:1710.05941 (2017)
Tan, M., Le, Q.V.: Efficientnet: rethinking model scaling for convolutional neural networks. arXiv preprint arXiv:1905.11946 (2019)
Tan, M., Pang, R., Le, Q.V.: Efficientdet: scalable and efficient object detection. In: Proceedings of the IEEE/CVF Conference on Computer Vision and Pattern Recognition, pp. 10781–10790 (2020)
Wu, Y., He, K.: Group normalization. In: Proceedings of the European conference on computer vision (ECCV), pp. 3–19 (2018)
Yushkevich, P.A., et al.: User-guided 3D active contour segmentation of anatomical structures: significantly improved efficiency and reliability. Neuroimage 31(3), 1116–1128 (2006)
Acknowledgement
We thank Israel Campiotti from NeuralMind for his help in the implementation of the modified EfficientDet architecture. D Carmo thanks the support from São Paulo Research Foundation (FAPESP) grant 2019/21964-4. R Lotufo thanks CNPq for the grant 310828/2018-0. This work is also supported by grant 2013/07559-3 (FAPESP-BRAINN).
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Carmo, D., Rittner, L., Lotufo, R. (2021). MultiATTUNet: Brain Tumor Segmentation and Survival Multitasking. In: Crimi, A., Bakas, S. (eds) Brainlesion: Glioma, Multiple Sclerosis, Stroke and Traumatic Brain Injuries. BrainLes 2020. Lecture Notes in Computer Science(), vol 12658. Springer, Cham. https://doi.org/10.1007/978-3-030-72084-1_38
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DOI: https://doi.org/10.1007/978-3-030-72084-1_38
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