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Influence of Dominance on Human Brain Activity During Voluntary Movement in Parkinson’s Disease

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Advances in Cognitive Research, Artificial Intelligence and Neuroinformatics (Intercognsci 2020)

Abstract

Hand dominance is known to make a robust bias on human brain activity in a normal state. Recent studies showed that simple motor tasks performed by a non-dominant hand caused increased activation, similar to that which occurs when more complex tests are performed with a dominant hand. The influence of dominance on brain activity in Parkinon’s disease (PD) remains unclear. In the present study we made an attempt to analyse the differences between brain activity during dominant and non-dominant hand movements in PD and compare it with the control group. We used functional MRI and an event-related paradigm to study the brain activity of 16 subjects in control group and 16 patients with PD during left and right hand movements. Data analysis showed few clearly lateralized clusters of activity in major motor areas in the control group and two hemispheric activation in motor and non-motor areas in PD group during both hand movements. We also found a deficit in the activation of the primary somatosensory cortex, primary motor cortex, basal ganglia, and insula during both movements in the PD group compared to controls. At the same time we found brain activity asymmetry caused by the dominance influence in the PD group. Thus, we have shown that although motor deficit in Parkinson's disease has a greater effect on habitual movement, the influence of dominance still persists and should be taken into account in PD studies.

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Acknowledgments

The reported study was funded by the Russian Foundation for Basic Research (RFBR), project number 19–315-90097. This study was also supported by the N.N. Semenov Federal Research Center for Chemical Physics, Russian Academy of Science, in the framework of State Contract no. 0082–2014-0001, AAAA-A17–117040610310-6.

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All authors have made substantial contributions to the study, as follows: Alexey Sedov, Alexey Tomskiy, Igor Pronin, the conception and design of the study; Veronika Filyushkina, Valentin Popov, Vadim Ushakov, Artem Batalov, acquisition of data; Alexey Sedov, Veronika Filyushkina, Valentin Popov, analysis and interpretation of data; Alexey Sedov, Veronika Filyushkina, drafting the article or revising it critically for important intellectual content. All authors gave final approval of the version to be submitted.

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Correspondence to Veronika Filyushkina .

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The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Appendix

Appendix

Fig. 5.
figure 5

Research design.

Table 2. Localization of activated areas during left and right hands movements in control group and PD patients

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Filyushkina, V. et al. (2021). Influence of Dominance on Human Brain Activity During Voluntary Movement in Parkinson’s Disease. In: Velichkovsky, B.M., Balaban, P.M., Ushakov, V.L. (eds) Advances in Cognitive Research, Artificial Intelligence and Neuroinformatics. Intercognsci 2020. Advances in Intelligent Systems and Computing, vol 1358. Springer, Cham. https://doi.org/10.1007/978-3-030-71637-0_68

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