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Pro-inflammatory Cytokines and the Depressive Phenotype

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Immuno-Psychiatry

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Abstract

In this review, the evidence is summarized implicating chronic low-grade inflammation in the pathophysiology of major depression. The possible mechanisms whereby such inflammatory changes lead to aberrant endocrine and neurotransmitter functions are also outlined and implicate the pro-inflammatory cytokines which are released from activated microglia as the primary cause in brain structure and function. It is now apparent that the inflammasome complex, which is located in the microglia, plays a crucial role in initiating the cytokine response.

The review concludes with a brief discussion of the need to develop drugs that specifically target the inflammasome complex and the potential difficulties that may arise from such procedures.

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Acknowledgments

Some parts of this review were prepared from Ceren Sahin Ozkartal’s Ph.D. dissertation thesis. (in Turkish).

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Authors and Affiliations

  1. Department of Pharmacology and Psychopharmacology Research Unit, University of Marmara, Istanbul, Turkey

    Feyza Aricioglu & Ceren Sahin Ozkartal

  2. Department of Pharmacology and Therapeutics, National University of Ireland, Galway, Ireland

    Brian E. Leonard

Authors
  1. Feyza Aricioglu
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  2. Ceren Sahin Ozkartal
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  3. Brian E. Leonard
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Correspondence to Brian E. Leonard .

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Editors and Affiliations

  1. Deakin University, IMPACT - The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Barwon Health, Geelong, VIC, Australia

    Michael Berk

  2. University Paris Est Créteil (UPEC), Inserm, IMRB (Translational NeuroPsychiatry lab), AP-HP, DMU IMPACT, AP-HP, Fondation FondaMental, Créteil, France

    Marion Leboyer

  3. UMC Groningen, Groningen, The Netherlands

    Iris E. Sommer

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Aricioglu, F., Ozkartal, C.S., Leonard, B.E. (2021). Pro-inflammatory Cytokines and the Depressive Phenotype. In: Berk, M., Leboyer, M., Sommer, I.E. (eds) Immuno-Psychiatry. Springer, Cham. https://doi.org/10.1007/978-3-030-71229-7_6

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