Abstract
Dengue fever is one of the significant health issues throughout the world, especially in tropical and subtropical territories. The cause of dengue fever is the dengue virus, which is a single-stranded RNA virus that is part of Flaviviridaeviruses family and has four distinct serotypes: DENV-1, DENV-2, DENV-3, and DENV-4. Dengue virus is spread to humans by the bite of the mosquitoes Aedes aegypti and Aedes albopictus. Clinically dengue fever symptoms range from mild (headache, nausea, vomited, pain in muscles and bones) to severe form such as dengue haemorrhagic fever and dengue shock syndrome. Since 1994 Pakistan has suffered from dengue endemic. Nevertheless, since 2006, the world has faced the worst dengue attack situation in which the disease has infected thousands of people and hundreds of people have been killed. DENV-2, DENV-3 and DENV-1 are most predominant serotypes in Pakistan.Popular diagnostic techniques being used in Pakistan are Enzyme-Linked Immunosorbent Assay (ELISA), polymerase chain reaction and rapid diagnostic tests, during differential diagnosis. Critical issues with dengue diagnosis include shortcomings in screening tests and a weak healthcare system. The major factors responsible for dengue epidemics in Pakistan are favourable climatic conditions, unplanned urbanisation, population growth, commuting and many socioeconomic factors etc. This chapter offers updates on Pakistan’s dengue epidemic and explains how to strengthen the region against dengue virus.
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References
Ahmad Z, Poh CL. The conserved molecular determinants of virulence in dengue virus. Int J Med Sci. 2019;16(3):355.
Ahmed A, Tanveer M, Khan G, Imran M. Dengue fever again in Pakistan: Are we going in the right direction. Public Health. 2017;152:153–6.
Akram DS, Igarashi A, Takasu T. Dengue virus infection among children with undifferentiated fever in Karachi. Ind J Pediatr. 1998;65(5):735–40.
Ali A, Ahmad H, Idrees M, Zahir F, Ali I. Circulating serotypes of dengue virus and their incursion into non-endemic areas of Pakistan; a serious threat. Virol J. 2016;13(1):144.
Chan Y, Tan H, Seah C, Li J, Chow V, Salahuddin N, et al. Dengue haemorrhagic fever outbreak in Karachi, Pakistan, 1994. 1995.
Cobelens FG, Groen J, Osterhaus AD, Leentvaar-Kuipers A, Wertheim-van Dillen PM, Kager PA. Incidence and risk factors of probable dengue virus infection among Dutch travellers to Asia. Tropical Med Int Health. 2002;7(4):331–8.
Junaidi I. Countrywide dengue cases nearing 50,000 Dawn: Dawn; 2019 https://www.dawn.com/news/1517320.
Dean CL, Wade J, Roback JD. Transfusion-transmitted infections: an update on product screening, diagnostic techniques, and the path ahead. J Clin Microbiol. 2018;56(7):e00352–18.
Fatima Z. Dengue infection in Pakistan: not an isolated problem. Lancet Infect Dis. 2019;19(12):1287–8.
Fatima Z, Idrees M, Bajwa MA, Tahir Z, Ullah O, Zia MQ, et al. Serotype and genotype analysis of dengue virus by sequencing followed by phylogenetic analysis using samples from three mini outbreaks-2007-2009 in Pakistan. BMC Microbiol. 2011;11(1):200.
Fatima Z, Akram M, Raza SM, Ali L, Hussain A, Amin I, et al. Dengue virus serotype 2 (DEN-2): the causative agent of 2011-dengue epidemic in Pakistan. Am J Biomed Sci. 2012;4(4):307–15.
Guzmán MG, Kourı G. Dengue diagnosis, advances and challenges. Int J Infect Dis. 2004;8(2):69–80.
Guzman MG, Gubler DJ, Izquierdo A, Martinez E, Halstead SB. Dengue infection. Nat Rev Dis Primers. 2016;2(1):1–25.
Heydari M, Metanat M, Rouzbeh-Far MA, Tabatabaei SM, Rakhshani M, Sepehri-Rad N, et al. Dengue fever as an emerging infection in Southeast Iran. Am J Trop Med Hyg. 2018;98(5):1469–71.
Internal data source: Surveillance Data: Field Epidemiology & Disease Surveillance Division [Internet]. https://www.nih.org.pk/. 2014–2019.
Jamil B, Hasan R, Zafar A, Bewley K, Chamberlain J, Mioulet V, et al. Dengue virus serotype 3, Karachi, Pakistan. Emerg Infect Dis. 2007;13(1):182.
Khan W. Dengue virus serotype 2 and 3 causing high morbidity and mortality in Swat, Pakistan. 2013.
Khan E, Hasan R, Mehraj V, Nasir A, Siddiqui J, Hewson R. Co-circulations of two genotypes of dengue virus in 2006 out-break of dengue hemorrhagic fever in Karachi, Pakistan. J Clin Virol. 2008;43(2):176–9.
Khanani MR, Arif A, Shaikh R. Dengue in Pakistan: Journey from a disease free to a hyper endemic nation. J Dow Univ Health Sci. 2011;5(3):81–4.
Kularatne SA. Dengue fever. Bmj. 2015;351:h4661.
Lo Y-C, Huang I-H, Ho T-C, Chien Y-W, Perng GC. Antiviral drugs and other therapeutic options for dengue virus infection. Curr Treat Options Infect Dis. 2017;9(2):185–93.
Mahmood N, Rana MY, Qureshi Z, Mujtaba G, Shaukat U. Prevalence and molecular characterization of dengue viruses serotypes in 2010 epidemic. Am J Med Sci. 2012;343(1):61–4.
Manoff SB, Sausser M, Falk Russell A, Martin J, Radley D, Hyatt D, et al. Immunogenicity and safety of an investigational tetravalent recombinant subunit vaccine for dengue: results of a Phase I randomized clinical trial in flavivirus-Naïve adults. Human Vaccines Immunother. 2019;15(9):2195–204.
Passos MNP, Santos LMJG, Pereira MRR, Casali CG, Fortes BdPM, Ortiz VLI, et al. Clinical differences observed in patients with dengue caused by different serotypes in the epidemic of 2001/2002, occurred in Rio de Janeiro. Revista da Sociedade Brasileira de Medicina Tropical. 2004;37(4).
Paul RE, Patel AY, Mirza S, Fisher-Hoch SP, Luby SP. Expansion of epidemic dengue viral infections to Pakistan. Int J Infect Dis. 1998;2(4):197–201.
Pulford J, Oakiva T, Angwin A, Bryant M, Mueller I, Hetzel MW. Indifferent to disease: a qualitative investigation of the reasons why some Papua New Guineans who own mosquito nets choose not to use them. Soc Sci Med. 2012;75(12):2283–90.
Qureshi JA, Notta NJ, Salahuddin N, Zaman V, Khan JA. An epidemic of dengue fever in Karachi-associated clinical manifestations. J Pak Med Assoc. 1997;47:178–80.
Rasheed S, Butlin R, Boots M. A review of dengue as an emerging disease in Pakistan. Public Health. 2013;127(1):11–7.
Sáez-Llorens X, Tricou V, Yu D, Rivera L, Tuboi S, Garbes P, et al. Safety and immunogenicity of one versus two doses of Takeda’s tetravalent dengue vaccine in children in Asia and Latin America: interim results from a phase 2, randomised, placebo-controlled study. Lancet Infect Dis. 2017;17(6):615–25.
Shaikh S, Kazmi SJH, Qureshi S. Monitoring the diversity of malaria and dengue vector in Karachi: studying variation of genera and subgenera of mosquitoes under different ecological conditions. Ecol Process. 2014;3(1):12.
Tahir U, Khan UH, Zubair MS. Wolbachia pipientis: A potential candidate for combating and eradicating dengue epidemics in Pakistan. Asia Pac J Trop Med. 2015;8(12):989–98.
Wahala WM, De Silva AM. The human antibody response to dengue virus infection. Viruses. 2011;3(12):2374–95.
Wiwanitkit V. Unusual mode of transmission of dengue. J Infect Dev Ctries. 2010;4(01):051–4.
Yousaf MZ, Siddique A, Ashfaq UA, Ali M. Scenario of dengue infection & its control in Pakistan: An up—date and way forward. Asia Pac J Tropical Med. 2018;11(1):15.
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Ahmed, A., Khan, G.M. (2021). Dengue Fever Epidemic in Pakistan and Its Control Measures: Where Are We Moving?. In: Ahmad, S.I. (eds) Human Viruses: Diseases, Treatments and Vaccines . Springer, Cham. https://doi.org/10.1007/978-3-030-71165-8_3
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DOI: https://doi.org/10.1007/978-3-030-71165-8_3
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