Skip to main content

Dengue Fever Epidemic in Pakistan and Its Control Measures: Where Are We Moving?

  • Chapter
  • First Online:
Human Viruses: Diseases, Treatments and Vaccines

Abstract

Dengue fever is one of the significant health issues throughout the world, especially in tropical and subtropical territories. The cause of dengue fever is the dengue virus, which is a single-stranded RNA virus that is part of Flaviviridaeviruses family and has four distinct serotypes: DENV-1, DENV-2, DENV-3, and DENV-4. Dengue virus is spread to humans by the bite of the mosquitoes Aedes aegypti and Aedes albopictus. Clinically dengue fever symptoms range from mild (headache, nausea, vomited, pain in muscles and bones) to severe form such as dengue haemorrhagic fever and dengue shock syndrome. Since 1994 Pakistan has suffered from dengue endemic. Nevertheless, since 2006, the world has faced the worst dengue attack situation in which the disease has infected thousands of people and hundreds of people have been killed. DENV-2, DENV-3 and DENV-1 are most predominant serotypes in Pakistan.Popular diagnostic techniques being used in Pakistan are Enzyme-Linked Immunosorbent Assay (ELISA), polymerase chain reaction and rapid diagnostic tests, during differential diagnosis. Critical issues with dengue diagnosis include shortcomings in screening tests and a weak healthcare system. The major factors responsible for dengue epidemics in Pakistan are favourable climatic conditions, unplanned urbanisation, population growth, commuting and many socioeconomic factors etc. This chapter offers updates on Pakistan’s dengue epidemic and explains how to strengthen the region against dengue virus.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 109.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 139.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 199.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Ahmad Z, Poh CL. The conserved molecular determinants of virulence in dengue virus. Int J Med Sci. 2019;16(3):355.

    Article  CAS  Google Scholar 

  • Ahmed A, Tanveer M, Khan G, Imran M. Dengue fever again in Pakistan: Are we going in the right direction. Public Health. 2017;152:153–6.

    Article  CAS  Google Scholar 

  • Akram DS, Igarashi A, Takasu T. Dengue virus infection among children with undifferentiated fever in Karachi. Ind J Pediatr. 1998;65(5):735–40.

    Article  CAS  Google Scholar 

  • Ali A, Ahmad H, Idrees M, Zahir F, Ali I. Circulating serotypes of dengue virus and their incursion into non-endemic areas of Pakistan; a serious threat. Virol J. 2016;13(1):144.

    Article  Google Scholar 

  • Chan Y, Tan H, Seah C, Li J, Chow V, Salahuddin N, et al. Dengue haemorrhagic fever outbreak in Karachi, Pakistan, 1994. 1995.

    Google Scholar 

  • Cobelens FG, Groen J, Osterhaus AD, Leentvaar-Kuipers A, Wertheim-van Dillen PM, Kager PA. Incidence and risk factors of probable dengue virus infection among Dutch travellers to Asia. Tropical Med Int Health. 2002;7(4):331–8.

    Article  Google Scholar 

  • Junaidi I. Countrywide dengue cases nearing 50,000 Dawn: Dawn; 2019 https://www.dawn.com/news/1517320.

  • Dean CL, Wade J, Roback JD. Transfusion-transmitted infections: an update on product screening, diagnostic techniques, and the path ahead. J Clin Microbiol. 2018;56(7):e00352–18.

    Google Scholar 

  • Fatima Z. Dengue infection in Pakistan: not an isolated problem. Lancet Infect Dis. 2019;19(12):1287–8.

    Article  Google Scholar 

  • Fatima Z, Idrees M, Bajwa MA, Tahir Z, Ullah O, Zia MQ, et al. Serotype and genotype analysis of dengue virus by sequencing followed by phylogenetic analysis using samples from three mini outbreaks-2007-2009 in Pakistan. BMC Microbiol. 2011;11(1):200.

    Article  Google Scholar 

  • Fatima Z, Akram M, Raza SM, Ali L, Hussain A, Amin I, et al. Dengue virus serotype 2 (DEN-2): the causative agent of 2011-dengue epidemic in Pakistan. Am J Biomed Sci. 2012;4(4):307–15.

    Google Scholar 

  • Guzmán MG, Kourı G. Dengue diagnosis, advances and challenges. Int J Infect Dis. 2004;8(2):69–80.

    Article  Google Scholar 

  • Guzman MG, Gubler DJ, Izquierdo A, Martinez E, Halstead SB. Dengue infection. Nat Rev Dis Primers. 2016;2(1):1–25.

    Article  Google Scholar 

  • Heydari M, Metanat M, Rouzbeh-Far MA, Tabatabaei SM, Rakhshani M, Sepehri-Rad N, et al. Dengue fever as an emerging infection in Southeast Iran. Am J Trop Med Hyg. 2018;98(5):1469–71.

    Article  Google Scholar 

  • Internal data source: Surveillance Data: Field Epidemiology & Disease Surveillance Division [Internet]. https://www.nih.org.pk/. 2014–2019.

  • Jamil B, Hasan R, Zafar A, Bewley K, Chamberlain J, Mioulet V, et al. Dengue virus serotype 3, Karachi, Pakistan. Emerg Infect Dis. 2007;13(1):182.

    Article  Google Scholar 

  • Khan W. Dengue virus serotype 2 and 3 causing high morbidity and mortality in Swat, Pakistan. 2013.

    Google Scholar 

  • Khan E, Hasan R, Mehraj V, Nasir A, Siddiqui J, Hewson R. Co-circulations of two genotypes of dengue virus in 2006 out-break of dengue hemorrhagic fever in Karachi, Pakistan. J Clin Virol. 2008;43(2):176–9.

    Article  CAS  Google Scholar 

  • Khanani MR, Arif A, Shaikh R. Dengue in Pakistan: Journey from a disease free to a hyper endemic nation. J Dow Univ Health Sci. 2011;5(3):81–4.

    Google Scholar 

  • Kularatne SA. Dengue fever. Bmj. 2015;351:h4661.

    Google Scholar 

  • Lo Y-C, Huang I-H, Ho T-C, Chien Y-W, Perng GC. Antiviral drugs and other therapeutic options for dengue virus infection. Curr Treat Options Infect Dis. 2017;9(2):185–93.

    Article  Google Scholar 

  • Mahmood N, Rana MY, Qureshi Z, Mujtaba G, Shaukat U. Prevalence and molecular characterization of dengue viruses serotypes in 2010 epidemic. Am J Med Sci. 2012;343(1):61–4.

    Article  Google Scholar 

  • Manoff SB, Sausser M, Falk Russell A, Martin J, Radley D, Hyatt D, et al. Immunogenicity and safety of an investigational tetravalent recombinant subunit vaccine for dengue: results of a Phase I randomized clinical trial in flavivirus-Naïve adults. Human Vaccines Immunother. 2019;15(9):2195–204.

    Article  Google Scholar 

  • Passos MNP, Santos LMJG, Pereira MRR, Casali CG, Fortes BdPM, Ortiz VLI, et al. Clinical differences observed in patients with dengue caused by different serotypes in the epidemic of 2001/2002, occurred in Rio de Janeiro. Revista da Sociedade Brasileira de Medicina Tropical. 2004;37(4).

    Google Scholar 

  • Paul RE, Patel AY, Mirza S, Fisher-Hoch SP, Luby SP. Expansion of epidemic dengue viral infections to Pakistan. Int J Infect Dis. 1998;2(4):197–201.

    Article  CAS  Google Scholar 

  • Pulford J, Oakiva T, Angwin A, Bryant M, Mueller I, Hetzel MW. Indifferent to disease: a qualitative investigation of the reasons why some Papua New Guineans who own mosquito nets choose not to use them. Soc Sci Med. 2012;75(12):2283–90.

    Article  Google Scholar 

  • Qureshi JA, Notta NJ, Salahuddin N, Zaman V, Khan JA. An epidemic of dengue fever in Karachi-associated clinical manifestations. J Pak Med Assoc. 1997;47:178–80.

    CAS  PubMed  Google Scholar 

  • Rasheed S, Butlin R, Boots M. A review of dengue as an emerging disease in Pakistan. Public Health. 2013;127(1):11–7.

    Article  CAS  Google Scholar 

  • Sáez-Llorens X, Tricou V, Yu D, Rivera L, Tuboi S, Garbes P, et al. Safety and immunogenicity of one versus two doses of Takeda’s tetravalent dengue vaccine in children in Asia and Latin America: interim results from a phase 2, randomised, placebo-controlled study. Lancet Infect Dis. 2017;17(6):615–25.

    Article  Google Scholar 

  • Shaikh S, Kazmi SJH, Qureshi S. Monitoring the diversity of malaria and dengue vector in Karachi: studying variation of genera and subgenera of mosquitoes under different ecological conditions. Ecol Process. 2014;3(1):12.

    Article  Google Scholar 

  • Tahir U, Khan UH, Zubair MS. Wolbachia pipientis: A potential candidate for combating and eradicating dengue epidemics in Pakistan. Asia Pac J Trop Med. 2015;8(12):989–98.

    Article  Google Scholar 

  • Wahala WM, De Silva AM. The human antibody response to dengue virus infection. Viruses. 2011;3(12):2374–95.

    Article  CAS  Google Scholar 

  • Wiwanitkit V. Unusual mode of transmission of dengue. J Infect Dev Ctries. 2010;4(01):051–4.

    Article  Google Scholar 

  • Yousaf MZ, Siddique A, Ashfaq UA, Ali M. Scenario of dengue infection & its control in Pakistan: An up—date and way forward. Asia Pac J Tropical Med. 2018;11(1):15.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Ali Ahmed .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2021 The Author(s), under exclusive license to Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Ahmed, A., Khan, G.M. (2021). Dengue Fever Epidemic in Pakistan and Its Control Measures: Where Are We Moving?. In: Ahmad, S.I. (eds) Human Viruses: Diseases, Treatments and Vaccines . Springer, Cham. https://doi.org/10.1007/978-3-030-71165-8_3

Download citation

Publish with us

Policies and ethics