Abstract
Patient was a 62 years old woman with invasive ductal carcinoma of the right breast, treated with lumpectomy and chemotherapy with doxorubicin. Three years later, she presented with exertional shortness of breath, NYHA class II. Echocardiogram revealed severely enlarged left ventricle and ejection fraction of 15% by 3D echocardiogram. She had normal coronary angiogram. She was diagnosed with dilated cardiomyopathy, secondary to doxorubicin treatment. She was started on guideline-directed medical therapy and after 3 months, LV EF improved to 32%, ramipril then switched to Sacubitril/valsartan (Entresto) and she underwent ICD insertion for primary prevention. On 2 years follow up, she was stable and euvolemic however still with LVEF of 34%.
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Rohani, A. (2021). Doxorubicin Induced Heart Failure with Reduced Ejection Fraction. In: Clinical Cases in Cardio-Oncology. Clinical Cases in Cardiology. Springer, Cham. https://doi.org/10.1007/978-3-030-71155-9_6
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DOI: https://doi.org/10.1007/978-3-030-71155-9_6
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