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Introduction to the Cardiac Implications of Radiotherapy

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Atlas of Imaging in Cardio-Oncology

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Abstract

Radiotherapy has long been used in the management of malignant and benign conditions alike, but only in recent decades have the long term implications of cardiac exposure been comprehensively delineated. In this chapter, we present the evolution of radiotherapy technologies, image guided targeting approaches, and patient positioning maneuvers, that have significantly reduced treatment-related morbidity, particularly as related to long term cardiac outcomes.

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References

  1. Röntgen W. Uber eine neue Art von Strahlen (On a new kind of rays). Vorläufige Mittheilung Aus den Sitzungsberichten der Würzburger Physik-medic Gesellschaft Würzburg: Stahel’sche K Hof und Universitätsbuchund Kunsthandlung; 1895. p. 137–47.

    Google Scholar 

  2. Curie P. Radioactive substances, especially radium. Nobel lecture 1905;6.

    Google Scholar 

  3. Ueyama T, Lécuyer C. Building Science-based Medicine at Stanford: Henry Kaplan and the Medical Linear Accelerator, 1948–1975. Devices and Designs: Springer; 2006. p. 137–55.

    Google Scholar 

  4. Pulsifer MB, Duncanson H, Grieco J, et al. Cognitive and adaptive outcomes after proton radiation for pediatric patients with brain tumors. Int J Radiat Oncol Biol Phys. 2018;102:391–8.

    Article  Google Scholar 

  5. Pulsifer MB, Sethi RV, Kuhlthau KA, MacDonald SM, Tarbell NJ, Yock TI. Early cognitive outcomes following proton radiation in pediatric patients with brain and central nervous system tumors. Int J Radiat Oncol Biol Phys. 2015;93:400–7.

    Article  Google Scholar 

  6. Cuzick J, Stewart H, Peto R, et al. Overview of randomized trials of postoperative adjuvant radiotherapy in breast cancer. Cancer Treat Rep. 1987;71:15–29.

    CAS  PubMed  Google Scholar 

  7. Wallgren A, Arner O, Bergström J, et al. Radiation therapy in operable breast cancer: results from the Stockholm trial on adjuvant radiotherapy. International Journal of Radiation Oncology* Biology* Physics 1986;12:533–7.

    Google Scholar 

  8. Harris JR, Hellman S. Put the “hockey stick” on ice. International Journal of Radiation Oncology Biology Physics 1988;15:497–9.

    Google Scholar 

  9. Goyal G, Silberstein PT, Armitage JO. Trends in use of radiation therapy for Hodgkin lymphoma from 2000 to 2012 on the basis of the national cancer data base. Clin Lymphoma Myeloma Leuk. 2016;16:12–7.

    Article  Google Scholar 

  10. Hull MC, Morris CG, Pepine CJ, Mendenhall NP. Valvular dysfunction and carotid, subclavian, and coronary artery disease in survivors of Hodgkin lymphoma treated with radiation therapy. JAMA. 2003;290:2831–7.

    Article  CAS  Google Scholar 

  11. Applefeld M, Slawson R, Spicer K, Singleton R, Wesley M, Wiernik P. Long-term cardiovascular evaluation of patients with Hodgkin’s disease treated by thoracic mantle radiation therapy. Cancer Treat Rep. 1982;66:1003–13.

    CAS  PubMed  Google Scholar 

  12. Adams MJ, Hardenbergh PH, Constine LS, Lipshultz SE. Radiation-associated cardiovascular disease. Crit Rev Oncol Hematol. 2003;45:55–75.

    Article  Google Scholar 

  13. Hancock SL, Donaldson SS, Hoppe RT. Cardiac disease following treatment of Hodgkin’s disease in children and adolescents. J Clin Oncol. 1993;11:1208–15.

    Article  CAS  Google Scholar 

  14. Darby SC, Ewertz M, McGale P, et al. Risk of ischemic heart disease in women after radiotherapy for breast cancer. N Engl J Med. 2013;368:987–98.

    Article  CAS  Google Scholar 

  15. Whelan TJ, Olivotto IA, Parulekar WR, et al. Regional nodal irradiation in early-stage breast cancer. N Engl J Med. 2015;373:307–16.

    Article  CAS  Google Scholar 

  16. Poortmans PM, Collette S, Kirkove C, et al. Internal mammary and medial supraclavicular irradiation in breast cancer. N Engl J Med. 2015;373:317–27.

    Article  CAS  Google Scholar 

  17. Bradley JD, Paulus R, Komaki R, et al. Standard-dose versus high-dose conformal radiotherapy with concurrent and consolidation carboplatin plus paclitaxel with or without cetuximab for patients with stage IIIA or IIIB non-small-cell lung cancer (RTOG 0617): a randomised, two-by-two factorial phase 3 study. Lancet Oncol. 2015;16:187–99.

    Article  CAS  Google Scholar 

  18. Cox JD. Are the results of RTOG 0617 mysterious? Int J Radiat Oncol Biol Phys. 2012;82:1042–4.

    Article  Google Scholar 

  19. Thor M, Deasy JO, Hu C, et al. Modeling the impact of cardio-pulmonary irradiation on overall survival in NRG Oncology trial RTOG 0617. Clinical Cancer Research 2020.

    Google Scholar 

  20. Veinot JP, Edwards WD. Pathology of radiation-induced heart disease: a surgical and autopsy study of 27 cases. Hum Pathol. 1996;27:766–73.

    Article  CAS  Google Scholar 

  21. Taunk NK, Haffty BG, Kostis JB, Goyal S. Radiation-induced heart disease: pathologic abnormalities and putative mechanisms. Front Oncol. 2015;5:39.

    Article  Google Scholar 

  22. Takahashi K, Morota M, Kagami Y, et al. Prospective study of postoperative whole breast radiotherapy for Japanese large-breasted women: a clinical and dosimetric comparisons between supine and prone positions and a dose measurement using a breast phantom. BMC Cancer. 2016;16:757.

    Article  Google Scholar 

  23. Hasson BF, Yeung D, Palta J. Bragg peak. In: Brady LW, Yaeger TE, editors. Encyclopedia of Radiation Oncology. Berlin/Heidelberg: Springer; 2013. https://doi.org/https://doi.org/10.1007/978-3-540-85516-3_657.

  24. Schönecker S, Walter F, Freislederer P, Marisch C, Scheithauer H, Harbeck N, et al. Treatment planning and evaluation of gated radiotherapy in left-sided breast cancer patients using the CatalystTM/SentinelTM system for deep inspiration breath-hold (DIBH). Radiat Oncol. 2016;11:143. https://doi.org/10.1186/s13014-016-0716-5.

    Article  PubMed  PubMed Central  Google Scholar 

  25. Aiello D, Borzì GR, Marino L, Umina V, Di Grazia AM. Comparison of deep inspiration breath hold and free breathing technique in left breast cancer irradiation: a dosimetric evaluation in 40 patients. J Radiation Oncol. 2019;8(1):89–96.

    CAS  Google Scholar 

  26. Choi KH, Kim J, Lee SW, Kang YN, Jang H. Dosimetric comparison between modulated arc therapy and static intensity modulated radiotherapy in thoracic esophageal cancer: a single institutional experience. Radiat Oncol J. 2018 Mar;36(1):63–70. doi: https://doi.org/10.3857/roj.2017.00241.

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Authors and Affiliations

  1. Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 22, New York, NY, 10065, USA

    Lior Z. Braunstein & Oren Cahlon

Authors
  1. Lior Z. Braunstein
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  2. Oren Cahlon
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Corresponding author

Correspondence to Lior Z. Braunstein .

Editor information

Editors and Affiliations

  1. Department of Medicine, Cardiology Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA

    Richard M. Steingart

  2. Memorial Sloan Kettering Cancer Center, New York, NY, USA

    Jennifer E. Liu

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Braunstein, L.Z., Cahlon, O. (2021). Introduction to the Cardiac Implications of Radiotherapy. In: Steingart, R.M., Liu, J.E. (eds) Atlas of Imaging in Cardio-Oncology. Springer, Cham. https://doi.org/10.1007/978-3-030-70998-3_22

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  • DOI: https://doi.org/10.1007/978-3-030-70998-3_22

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-70997-6

  • Online ISBN: 978-3-030-70998-3

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