Abstract
This chapter begins by exploring the historical framework of the understanding of peritoneal dialysis adequacy. A survey of the evidence base is presented to explain the evolution of thought on the topic, with emphasis on the current appreciation of residual kidney function as an important contributor to peritoneal dialysis adequacy. It concludes with some practical recommendations related to preservation of residual kidney function as well as ways to enhance peritoneal adequacy by modifying the dialysis prescription.
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References
Giovannetti S. Diet in chronic uremia. Clin Nephrol. 1967;3:230–6.
Scribner BH. Discussion. Trans Am Soc Artif Intern Organs. 1965;11:29.
Babb AL, Popovich RP, Christopher TG, Scribner BH. The genesis of the square meter-hour hypothesis. Trans Am Soc Artif Intern Organs. 1971;17:81–91.
Lowrie EG, et al. Effect of the hemodialysis prescription on patient morbidity: report from the National Cooperative Dialysis Study. N Engl J Med. 1981;305(20):1176–81.
Oreopoulos DG. Beyond Kt/V: Redefining adequacy of dialysis in the 21st century. Int Urol Nephrol. 2002;34(3):393–403.
Amrhein V, Greenland S, McShane B. Scientists rise up against statistical significance. Nature. 2018;567:305–7.
Sargent JA, Gotch FA. The analysis of concentration dependence of uremic lesions in clinical studies. Kidney Int. 1975;7(Suppl 2):S35–44.
Gotch FA, Sargent JA. A mechanistic analysis of the National Cooperative Dialysis Study (NCDS). Kidney Int. 1985;28:526–34.
Teehan BP, Schleifer CR, Brown JM, et al. Urea kinetic analysis and clinical outcome on CAPD. A five year longitudinal study. Adv Perit Dial. 1990;6:181–5.
Churchill DN, Taylor DW, Keshaviah PR, CANUSA Peritoneal Dialysis Study Group. Adequacy of dialysis and nutrition in continuous peritoneal dialysis: association with clinical outcomes. J Am Soc Nephrol. 1996;7:198–207.
NKF-DOQI clinical practice guidelines for peritoneal dialysis adequacy Am J Kidney Dis. 1997; 30(3):S67–S136.
Paniagua R, Amato D, Vonesh E, et al. Effects of increased peritoneal clearances on mortality rates in peritoneal dialysis: ADEMEX, a prospective, randomized, controlled trial. J Am Soc Nephrol. 2002;13:1307–20.
Lo WK, Ho YW, et al. Effect of Kt/V on survival and clinical outcome in CAPD patients in a randomized prospective study. Kidney Int. 2003;64(2):649–56.
Eknoyan G, Beck GJ, Cheung AK, et al. Effect of dialysis dose and membrane flux in maintenance hemodialysis. New Engl J Med. 2003;347:2010–9.
Bargman JM, Thorpe KE, Churchill DN. Relative contribution of residual renal function and peritoneal clearance to adequacy of dialysis: a reanalysis of the CANUSA study. J Am Soc Nephrol. 2001;12:2158–62.
Maiorca R, et al. Predictive value of dialysis adequacy and nutritional indices for mortality and morbidity in CAPD and HD patients. A longitudinal study. Nephrol Dial Transplant. 1995;10(12):2295–305.
Diaz-Buxo JA, et al. Peritoneal dialysis adequacy: a model to assess feasibility with various modalities. Kidney Int. 1999;55(6):2493–501.
Termorshuizen F, Korevaar JC, Dekker FW, van Manen JG, Boeschoten EW, Krediet RT. The relative importance of residual renal function compared with peritoneal clearance for patient survival and quality of life: an analysis of the Netherlands Cooperative Study on the Adequacy of Dialysis (NECOSAD)-2. Am J Kidney Dis. 2003;41:1293–302.
Wang AY, Woo J, Wang M, et al. Important differentiation of factors that predict outcome in peritoneal dialysis patients with different degrees of residual renal function. Nephrol Dial Transplant. 2005;20:396–403.
Chung SH, Heimburger O, Stenvinkel P, Wang T, Lindholm B. Influence of peritoneal transport rate, inflammation, and fluid removal on nutritional status and clinical outcome in prevalent peritoneal dialysis patients. Perit Dial Int. 2003;23:174–83.
Wang AY, Wang M, Woo J, et al. Inflammation, residual kidney function, and cardiac hypertrophy are interrelated and combine adversely to enhance mortality and cardiovascular death risk of peritoneal dialysis patients. J Am Soc Nephrol. 2004;15:2186–94.
Pecoits-Filho R, Heimburger O, Barany P, et al. Associations between circulating inflammatory markers and residual renal function in CRF patients. Am J Kidney Dis. 2003;41:1212–8.
Ates K, Nergizoglu G, Keven K, et al. Effect of fluid and sodium removal on mortality in peritoneal dialysis patients. Kidney Int. 2001;60:767–76.
Konings CJ, Kooman JP, Schonck M, et al. Fluid status in CAPD patients is related to peritoneal transport and residual renal function: evidence from a longitudinal study. Nephrol Dial Transplant. 2003;18:797–803.
Konings CJ, Kooman JP, Schonck M, et al. Fluid status, blood pressure, and cardiovascular abnormalities in patients on peritoneal dialysis. Perit Dial Int. 2002;22:477–87.
Bammens B, et al. Removal of middle molecules and protein-bound solutes by peritoneal dialysis and relation with uremic symptoms. Kidney Int. 2003;64(6):2238–43.
Leong SC, et al. Residual function effectively controls plasma concentrations of secreted solutes in patients on twice weekly hemodialysis. J Am Soc Nephrol. 2018;29(7):992–1999.
Brown EA, et al. Survival of functionally anuric patients on automated peritoneal dialysis: the European APD Outcome Study. J Am Soc Nephrol. 2003;14(11):2948–57.
Konings CJ, Kooman JP, Gladziwa U, van der Sande FM, Leunissen KM. A decline in residual glomerular filtration during the use of icodextrin may be due to underhydration. Kidney Int. 2005;67:1190–1.
Persson PB, Patzak A. Renal haemodynamic alterations in contrast medium-induced nephropathy and the benefit of hydration. Nephrol Dial Transplant. 2005;20(Suppl 1):i2–5.
Zhao S-j, Zhong Z-s, Qi G-x, Tian W. The efficacy of N-acetylcysteine plus sodium bicarbonate in the prevention of contrast-induced nephropathy after cardiac catheterization and percutaneous coronary intervention: a meta-analysis of randomized controlled trials. Int J Cardiol. 2016;221:251–9.
Li PK, Chow KM, Wong TY, Leung CB, Szeto CC. Effects of an angiotensin-converting enzyme inhibitor on residual renal function in patients receiving peritoneal dialysis. A randomized, controlled study. Ann Intern Med. 2003;139:105–12.
Suzuki H, Kanno Y, Sugahara S, Okada H, Nakamoto H. Effects of an angiotensin II receptor blocker, valsartan, on residual renal functioning patients on CAPD. Am J Kidney Dis. 2004;43:1056–64.
Davies SJ. Peritoneal dialysis in the patient with a failing renal allograft. Perit Dial Int. 2001;21(Suppl 3):S280–4.
Jassal SV, et al. Continued transplant immunosuppression may prolong survival after return to peritoneal dialysis: results of a decision analysis. Am J Kidney Dis. 2002;40(1):178–83.
Fischbach M, et al. Optimizing peritoneal dialysis prescription for volume control: the importance of varying dwell time and dwell volume. Pediatr Nephrol. 2014;29(8):1321–7.
Plum J, et al. Efficacy and safety of a 7.5% icodextrin peritoneal dialysis solution in patients treated with automated peritoneal dialysis. Am J Kidney Dis. 2002;39:862–71.
Brown E et al: International society for peritoneal dialysis practice recommendations: Prescribing High Quality Goal-Directed Peritoneal dialysis. Perit Dial Int. 2020 (in press).
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Ibrahim, A.Z., Bargman, J.M. (2021). Peritoneal Dialysis Adequacy. In: Rastogi, A., Lerma, E.V., Bargman, J.M. (eds) Applied Peritoneal Dialysis. Springer, Cham. https://doi.org/10.1007/978-3-030-70897-9_10
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DOI: https://doi.org/10.1007/978-3-030-70897-9_10
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