Abstract
This introduction aims to give the reader a brief outline of the content of each of the following chapters of this book. It introduces the matters discussed but in a way it also dives straight into the heart of the problem of antimicrobial resistance. It touches on conflicting individual and collective health needs, the high human and economic costs, the far-reaching consequences of outbreaks, especially when they are not dealt with properly, the current status of antimicrobial resistance, the role of infection prevention and medical microbiology, the contribution of the veterinary use of antibiotics to the overall problem and the quest for solutions. This book is based both on the original Dutch 2013 edition and on the German 2015 edition. Most of the interviews it refers to were held between the end of 2011 and spring 2015. This English version has been updated and a number of new interviews were held to make that possible.
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Notes
- 1.
KPCÂ =Â Klebsiella pneumoniae carbapenemase. Carbapenemase is an enzyme that makes bacteria resistant to the important carbapenem class of antibiotics. Carbapenems are high-performance antibiotics with relatively few side effects.
- 2.
Escherichia coli or, for brevity’s sake, E. coli were named after their discoverer, Theodor Escherich.
- 3.
OXA-48 is an enzyme that makes bacteria resistant to the highly effective carbapenem antibiotics.
- 4.
The enzyme that makes the bacteria resistant was named after the place where it was first identified: New Delhi metallo beta lactamase.
- 5.
Rijksinstituut voor Volksgezondheid en Milieu (Dutch National Institute for Public Health and the Environment).
References
AMR Action Fund. (2020). Bridging the gap between science and patients. Accessed March 27, 2021, from https://www.amractionfund.com/
AMR Industry Alliance. (2016). Our members. Accessed March 27, 2021, from https://www.amrindustryalliance.org/our-members/
Antibiotic Research. (2016). AstraZeneca pulls out of antibiotic drug development. Accessed March 27, 2021, from https://bit.ly/39mePHH
BBC. (2013). Antibiotic resistance ‘as big a risk as terrorism’- medical chief. Accessed March 27, 2021, from https://www.bbc.co.uk/news/health-21737844
Bhutta, Z. A. (2010). Millennium development goals and child survival: Does antimicrobial resistance matter? In Presented at the conference global need for effective antibiotics – Moving towards concerted action, Uppsala, 6–8 September 2010. Accessed October 18, 2020, from https://bit.ly/393MJ32
Blaak, H., Schets, F. M., & Italiaander, R., et al. (2010). Antibioticaresistente bacteriën in Nederlands oppervlaktewater in veeteeltrijk gebied. Accessed 18 Oct 2020, see page 5 for an English abstract from https://bit.ly/3q9Nsqv
Blaak, H., Van Rooijen, S. R., & Schuijt, M. S. (2011). Prevalence of antibiotic resistant bacteria in the rivers Meuse, Rhine, and New Meuse. Accessed October 18, 2020, from https://bit.ly/2L03RyN
Bloomberg. (2018). Novartis exits antibiotic research, cuts 140 jobs in bay area. Accessed March 27, 2021, from https://bloom.bg/3w4XywA
Bonten, M. (2018). AMR deaths in Europe. Reflections on infection prevention and control. Accessed from https://reflectionsipc.com/2018/11/07/amr-deaths-in-europe/#more-4078
Bundesamt für Justiz. (2011). Gesetz zur Verhütung und Bekämpfung von Infektionskrankheiten beim Menschen. In German. (see sections 3, 8 and 23). Accessed March 27, 2021, from http://www.gesetze-im-internet.de/ifsg/index.html
Cassini, A., Högberg, L. D., Plachouras, D., et al. (2019). Attributable deaths and disability-adjusted life-years caused by infections with antibiotic-resistant bacteria in the EU and the European Economic Area in 2015: A population-level modelling analysis. The Lancet Infectious Diseases, 19, 56–66. https://doi.org/10.1016/S1473-3099(18)30605-4.
CDC (Centers for Disease Control and Prevention). (2013). Antibiotic resistance threats in the United States, 2013. Accessed October 18, 2020, from https://www.cdc.gov/drugresistance/pdf/ar-threats-2013-508.pdf
CDC (Centers for Disease Control and Prevention). (2017). Antibiotic use in the United States, 2017 progress and opportunities. Accessed October 18, 2020, from https://bit.ly/2L7p5KU
CDC (Centers for Disease Control and Prevention). (2019a). Antibiotic resistance threats in the United States, 2019. Accessed October 18, 2020, from www.cdc.gov/DrugResistance/Biggest-Threats.html
CDC (Centers for Disease Control and Prevention). (2019b). Antibiotic use in the United States, 2018 update: Progress and opportunities. Accessed October 18, 2020, from https://bit.ly/3hOgGYX
Davies, S., et al. (2013). Annual report of the Chief Medical Officer Volume Two, 2011 infections and the rise of antimicrobial resistance. Accessed October 18, 2020, from https://bit.ly/2Xkfi6M
ECDC. (2020). Antimicrobial resistance in the EU/EEA (EARS-Net) – Annual Epidemiological Report for 2019. Accessed January 7, 2021, from https://bit.ly/3ntksIw
ECDC/EMEA (European Centre for Disease Prevention and Control/European Medicines Agency). (2009). Joint technical report. The bacterial challenge: Time to react A call to narrow the gap between multidrug-resistant bacteria in the EU and the development of new antibacterial agents. https://doi.org/10.2900/2518. Accessed October 18, 2020, from https://bit.ly/38k3GXS
FAO Regional Conference for Asia and the Pacific. (2020, 17–20 February). Thirty-fifth session, Thimphu, Bhutan. Report on Antimicrobial Resistance (AMR). Accessed March 27, 2021, from http://www.fao.org/3/nb741en/nb741en.pdf
Glupczynski, Y., & Gordts, B. (2011a). Maatregelen te nemen naar aanleiding van de toename van carbapenemase producerende enterobacteriën (CPE) in België. Advies van de Hoge Gezondheidsraad nr. 8791. In Dutch. Accessed October 18, 2020, from http://bit.do/fHkQ5
Glupczynski, Y., & Gordts, B. (2011b). Mesures à prendre suite à l’émergence des entérobactéries productrices de carbapénémases (CPE) en Belgique. Avis du Conseil Supérieur de la Santé N° 8791. Accessed October 18, 2020, from http://bit.do/fHkRg
Heederik, D. J. J., Bonten, M. J. M., Van Geijlswijk, I. M., et al. (2020). Usage of antibiotics in agricultural livestock in the Netherlands in 2019 trends and benchmarking of livestock farms and veterinarians SDa/1153/2020. Accessed October 18, 2020, from https://www.autoriteitdiergeneesmiddelen.nl/en/available-now
Independent. (2011). Antibiotics losing the fight against deadly bacteria. Accessed March 27, 2021, from https://bit.ly/31qOxQm
Klevens, R. M., Morrison, M. A., Nadle, J., et al. (2007). Invasive methicillin-resistant Staphylococcus aureus infections in the United States. JAMA, 298(15), 1763–1771. https://www.cdc.gov/mrsa/pdf/InvasiveMRSA_JAMA2007.pdf
Knapp, C. W., Dolfing, J., Ehlert, P. A. I., et al. (2010). Evidence of increasing antibiotic resistance gene abundances in archived soils since 1940. Environmental Science & Technology, 44(2), 580–587. https://doi.org/10.1021/es901221x. https://pubs.acs.org/doi/abs/10.1021/es901221x
Labyrint, T. V. (2012). Uitgewerkte antibiotica. In Dutch. Accessed March 27, 2021, from https://www.npostart.nl/labyrint/17-10-2012/VPWON_1179058
NDR. (2019a). Antibiotika-Forschung: warum Unternehmen aussteigen. In German. Accessed March 27, 2021, from https://bit.ly/3sv9oh5
NDR. (2019b). The end of antibiotics? Accessed March 27, 2021, from https://bit.ly/3szs9Ag
O’Neill, J. (2016). Review on antimicrobial resistance. Tackling drug-resistant infections globally: Final report and recommendations. Accessed October 18, 2020, from https://bit.ly/2Xmade4
ONS. (2012). Office for National Statistics. Statistical Bulletin. Deaths involving MRSA: England and Wales, 2007 to 2011. Accessed from https://bit.ly/2Xfa3Fs
Östholm-Balkhed, A., Tärnberg, M., Nilsson, M., et al. (2013). Travel-associated faecal colonization with ESBL-producing Enterobacteriaceae: Incidence and risk factors. Journal of Antimicrobial Chemotherapy, 68(9), 2144–2153. https://doi.org/10.1093/jac/dkt167.
Overdevest, I., Willemsen, I., Rijnsburger, M., et al. (2011). Extended-spectrum β-lactamase genes of Escherichia coli in chicken meat and humans, the Netherlands. Emerging Infectious Diseases, 17(7), 1216–1222. https://doi.org/10.3201/eid1707.110209. https://wwwnc.cdc.gov/eid/article/17/7/11-0209_article.
PHE. (2019). Public Health England. Thirty-day all-cause mortality following MRSA, MSSA and Gram-negative bacteraemia and C. difficile infections 2018/19. Accessed January 7, 2021, from https://bit.ly/397bhIl
Pietersen, E., Ignatius, E., Streicher, E., et al. (2014). Long-term outcomes of patients with extensively drug-resistant tuberculosis in South-Africa: A cohort study. The Lancet, 383(9924), 1230–1239. https://doi.org/10.1016/S0140-6736(13)62675-6.
ReAct. (2018). Despite industry declaration AMR commitments Sanofi quits R&D on anti-infectives. Accessed March 27, 2021, from https://bit.ly/39kO9aj
Reuland, E. A., al Naiemi, N., Raadsen, S. A., et al. (2014). Prevalence of ESBL-producing Enterobacteriaceae in raw vegetables. European Journal of Clinical Microbiology & Infectious Diseases, 33, 1843–1846. https://doi.org/10.1007/s10096-014-2142-7.
RKI. (2020). Robert Koch Institut. Infektionsepidemiologisches Jahrbuch meldepflichtiger Krankheiten für 2019. In German. Accessed January 7, 2021, from https://bit.ly/35iZllN
Roberts, R. R., Hota, B., Ahmad, I., et al. (2009). Hospital and societal costs of antimicrobial-resistant infections in a Chicago Teaching Hospital: Implications for antibiotic stewardship. Clinical Infectious Diseases, 49(8), 1175–1184. https://doi.org/10.1086/605630.
Singh, S. K., Sengupta, S., Antony, R., et al. (2019). Variations in antibiotic use across India: Multi-centre study through Global Point Prevalence survey. Journal of Hospital Infection, 103(3), 280–283. https://doi.org/10.1016/j.jhin.2019.05.014.
The Guardian. (2013). Antibiotics catastrophe warning from chief-medical officer – video. Accessed March 27, 2021, from https://bit.ly/3w3VxRc
The Lancet. (2013). Antibiotic resistance: A final warning. The Lancet, 382(9898), 1072. https://doi.org/10.1016/S0140-6736(13)62008-5.
The New York Times. (2013). Avoiding a time when bacteria can no longer be stopped. Accessed March 27, 2021, from https://nyti.ms/39hM672
Udwadia, Z. F., Amale, R. A., Ajbani, K. K., et al. (2012). Totally drug-resistant tuberculosis in India. Clinical Infectious Diseases, 54(4), 579–581. https://doi.org/10.1093/cid/cir889.
Van Cleef, A. G. L., Kluytmans, J. A. J. W., Van Benthem, B. H. B., et al. (2012). Cross border comparison of MRSA bacteraemia between The Netherlands and North Rhine-Westphalia (Germany): A cross-sectional study. PLoS One. https://doi.org/10.1371/journal.pone.0042787.
Wassenberg, M., Kluytmans, J., Erdkamp, S., et al. (2012). Costs and benefits of rapid screening of methicillin-resistant Staphylococcus aureus carriage in intensive care units: A prospective multicenter study. Critical Care, 16, R22. https://doi.org/10.1186/cc11184.
WHO. (2020a). 2019 Antibacterial agents in clinical development: an analysis of the antibacterial clinical development pipeline. Accessed March 27, 2021, from https://bit.ly/2QLRcBZ
WHO. (2020b). Antibacterial agents in preclinical development: an open access database. Accessed March 27, 2021, from https://bit.ly/3fh7Qn5
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van den Brink, R. (2021). Introduction. In: The End of an Antibiotic Era. Springer, Cham. https://doi.org/10.1007/978-3-030-70723-1_1
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