Abstract
The aim of this study was to investigate the printability of different compositions of biomaterials to be potentially used in bioprinting of cartilaginous substitutes. Part of the compositions contained pulverized devitalized cartilage (DVC), which confers the necessary biochemical complexity for bioprinted scaffolds, and some compositions contained granulated polycaprolactone (PCL), that provides greater mechanical resistance to the scaffolds. An additive manufacturing equipment specially customized for bioprinting was used in the printing tests. In addition to bringing biochemical advantages, DVC increases consistency of scaffolds. PCL, on the other hand, has to be reduced to smaller granulometries for better results, since it has obstructed the printing needles. Modifications to the printer design have been suggested to make printing viable using high viscosity biomaterials and 0.41 mm or thinner needles, which may provide greater resolution and shorter distances for diffusion of nutrients and oxygen inside the scaffolds.
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References
Kiyotake E, Beck E, Detamore M (2016) Cartilage extracellular matrix as a biomaterial for cartilage regeneration. Ann NY Acad Sci 2016:139–159
Farr J, Yao J (2011) Chondral defect repair with particulated juvenile cartilage allograft. Cartilage 2:346–353
Kang H, Lee S, Ko I et al. (2016) A 3D bioprinting system to produce human-scale tissue constructs with structural integrity. Nat Biotechnol, 1–11
Garrigues N, Little D, Adams J et al (2014) Electrospun cartilage-derived matrix scaffolds for cartilage tissue engineering. J Biomed Mater Res 102a: 3998–4008
Paxton N, Smolan W, Böck T et al (2017) Proposal to assess printability of bioinks for extrusion-based bioprinting and evaluation of rheological properties governing bioprintability. Biofabrication 9. https://doi.org/10.1088/1758-5090/aa8dd8
Wüst S, Müller R, Hofmann S (2015) 3D Bioprinting of complex channels-effects of material, orientation, geometry, and cell embedding. J Biomed Mater Res A 103:2558–2570
Acknowledgements
The authors would like to thank the Brazilian agencies CNPq (Conselho Nacional de Desenvolvimento Científico e Tecnológico) and FAPEMIG (Fundação de Amparo à Pesquisa do Estado de Minas Gerais) for their support.
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The authors declare that they have no conflict of interest.
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Poley, I.M., Silveira, R., Dernowsek, J.A., Casas, E.B.L. (2022). Qualitative Aspects of Three-Dimensional Printing of Biomaterials Containing Devitalized Cartilage and Polycaprolactone. In: Bastos-Filho, T.F., de Oliveira Caldeira, E.M., Frizera-Neto, A. (eds) XXVII Brazilian Congress on Biomedical Engineering. CBEB 2020. IFMBE Proceedings, vol 83. Springer, Cham. https://doi.org/10.1007/978-3-030-70601-2_17
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DOI: https://doi.org/10.1007/978-3-030-70601-2_17
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