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Conductive Gels as a Tool for Electric Field Homogenization and Electroporation in Discontinuous Regions: In Vitro and In Silico Study

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XXVII Brazilian Congress on Biomedical Engineering (CBEB 2020)

Part of the book series: IFMBE Proceedings ((IFMBE,volume 83))

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Abstract

Electrochemotherapy (ECT) is a cancer treatment that combines chemotherapy and electroporation (EP) where EP is used to increase cells membrane permeability, facilitating the entrance of drugs into cancer cells. For successful treatment, the entire tumor region needs to be exposed to an adequate electric field intensity. In silico and in vitro studies are used in a pre-treatment step to analyse the electric field distribution and possible mistakes, especially in irregular and complex tissue structures such as protuberances and holes. Conductive gels can be used to fill irregular tissue structures and make the electric field distribution homogenous. In this paper, an in silico study and in vitro vegetal model were used to evaluate the effectiveness of commercial conductive gels in electric field homogenization of discontinuity areas. Both studies demonstrate that conductive gels were effective in homogenizing electric field in the discontinuity region.

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Acknowledgements

The author thanks the funding agencies CAPES and CNPq.

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Authors and Affiliations

  1. Instituto de Engenharia Biomédica (IEB-UFSC), Universidade Federal de Santa Catarina, R. Eng. Agrônomo Andrei Cristian Ferreira, s/n-Trindade, Florianópolis, Brazil

    L. B. Lopes, G. B. Pintarelli & D. O. H. Suzuki

Authors
  1. L. B. Lopes
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  2. G. B. Pintarelli
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  3. D. O. H. Suzuki
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Corresponding author

Correspondence to L. B. Lopes .

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Editors and Affiliations

  1. Department of Electrical Engineering, Universidade Federal do Espírito Santo, Vitória, Brazil

    Teodiano Freire Bastos-Filho

  2. Department of Electrical Engineering, Universidade Federal do Espírito Santo, Vitória, Brazil

    Eliete Maria de Oliveira Caldeira

  3. Department of Electrical Engineering, Universidade Federal do Espírito Santo, Vitória, Brazil

    Anselmo Frizera-Neto

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Lopes, L.B., Pintarelli, G.B., Suzuki, D.O.H. (2022). Conductive Gels as a Tool for Electric Field Homogenization and Electroporation in Discontinuous Regions: In Vitro and In Silico Study. In: Bastos-Filho, T.F., de Oliveira Caldeira, E.M., Frizera-Neto, A. (eds) XXVII Brazilian Congress on Biomedical Engineering. CBEB 2020. IFMBE Proceedings, vol 83. Springer, Cham. https://doi.org/10.1007/978-3-030-70601-2_167

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  • DOI: https://doi.org/10.1007/978-3-030-70601-2_167

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-70600-5

  • Online ISBN: 978-3-030-70601-2

  • eBook Packages: EngineeringEngineering (R0)

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