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Acute Kidney Injury During Pregnancy

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Obstetric Catastrophes
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Abstract

The term AKI almost replaces the acute renal failure terminology in all recent literature and reflecting that even a smaller decline in kidney function is of substantial clinical relevance due to associated morbidities and mortality (Van Hook , Clin Obstet Gynecol 57:851–861, 2014).

There are multiple etiological factors during pregnancy that can lead to pregnancy-related acute kidney injury (PR-AKI), and it can happen at any time throughout pregnancy and the postpartum period. This terminology (PR-AKI) reflects a critical obstetric complication that is associated with significant maternal and fetal morbidity and mortality. Although the incidence of PR-AKI declined worldwide in the last six decades, a report was showing a recent shift in the occurrence of this disease. With advanced service management in obstetric care, PR-AKI incidence has been reduced from 1/3000 to 1/20000 since the 1960s (Gammill, Jeyabalan, Crit Care Med 33:S372–S384, 2005). Addressing the physiological adaptations during pregnancy and labor of the renal system is essential for proper approaching and management of PR- AKI and can prevent further sequelae of comorbidities. With a full recovery rate ranging from 60% to 90% after an AKI episode (Odutayo, Hladunewich, Clin J Am Soc Nephrol 7(12):2073–2080, 2012).

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References

  1. Mantel GD. Care of the critically ill parturient: oliguria and renal failure. Best Pract Res Clin Obstet Gynaecol. 2001;15:563–81.

    Article  CAS  Google Scholar 

  2. Bellomo R, Ronco C, Kellum JA, et al. Acute renal failure – definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group. Crit Care. 2004;8:R204–12.

    Article  Google Scholar 

  3. Hussein W, Lafayette RA. Renal function in normal and disordered pregnancy. Curr Opin Nephrol Hypertens. 2014;23:46–53.

    Article  CAS  Google Scholar 

  4. Abosaif NY, Tolba YA, Heap M, Russell J, El Nahas AM. The outcome of acute renal failure in the intensive care unit according to RIFLE: model application, sensitivity, and predictability. Am J Kidney Dis. 2005;46:1038–48.

    Article  Google Scholar 

  5. Balofsky A, Fedarau M. Renal failure in pregnancy. Crit Care Clin. 2016;32(1):73–83.

    Article  Google Scholar 

  6. Kattah A, Milic N, White W, Garovic V. Spot urine protein measurements in normotensive pregnancies, pregnancies with isolated proteinuria and preeclampsia. Am J Physiol Regul Integr Comp Physiol. 2017;313(4):R418–24.

    Article  CAS  Google Scholar 

  7. Aluvihare VR, Kallikourdis M, Betz AG. Regulatory T cells mediate maternal tolerance to the fetus. Nat Immunol. 2004;5(3):266–71.

    Article  CAS  Google Scholar 

  8. Van Hook JW. Acute kidney injury during pregnancy. Clin Obstet Gynecol. 2014;57:851–61.

    Article  Google Scholar 

  9. Odutayo A, Hladunewich M. Obstetric nephrology: renal hemodynamic and metabolic physiology in normal pregnancy. Clin J Am Soc Nephrol. 2012;7(12):2073–80.

    Article  Google Scholar 

  10. Fakhouri F, Vercel C, Frémeaux-Bacchi V. Obstetric nephrology: AKI and thrombotic microangiopathies in pregnancy. Clin J Am Soc Nephrol. 2012;7:2100–6.

    Article  Google Scholar 

  11. Munnur U, Bandi V, Guntupalli KK. Management principles of the critically ill obstetric patient. Clin Chest Med. 2011;32:53–60.

    Article  Google Scholar 

  12. Piccoli GB, Gaglioti P, Attini R, et al. Pre-eclampsia or chronic kidney disease? The flow hypothesis. Nephrol Dial Transplant. 2013;28:1199–206.

    Article  CAS  Google Scholar 

  13. Sibai BM, Villar MA, Mabie BC. Acute renal failure in hypertensive disorders of pregnancy. Pregnancy outcome and remote prognosis in thirty-one consecutive cases. Am J Obstet Gynecol. 1990;162(3):777–83.

    Article  CAS  Google Scholar 

  14. Henderson JT, Thompson JH, Burda BU, Cantor A. Preeclampsia screening: evidence report and systematic review for the US Preventive Services Task Force. JAMA. 2017;317(16):1668–83.

    Article  Google Scholar 

  15. Gammill HS, Jeyabalan A. Acute renal failure in pregnancy. Crit Care Med. 2005;33:S372–84.

    Article  Google Scholar 

  16. Sibai BM, Ramadan MK, Usta I, Salama M, Mercer BM, Friedman SA. Maternal morbidity and mortality in 442 pregnancies with hemolysis, elevated liver enzymes, and low platelets (HELLP syndrome). Am J Obstet Gynecol. 1993;169(4):1000–6.

    Article  CAS  Google Scholar 

  17. Conrad K, Lindheimer M. Renal and cardiovascular alterations. In: Lindheimer M, editor. Chesley’s hypertensive disorders in pregnancy. Stamford: Appleton & Lange; 1999. p. 263–326.

    Google Scholar 

  18. Brown M, Child RP, O’Connor M, et al. Pregnancy-induced hypertension and renal failure: clinical importance of diuretics, plasma volume, and vasospasm. Aust N Z J Obstet Gynaecol. 1989;29:230–2.

    Article  CAS  Google Scholar 

  19. Myers DL, Scotti RJ. Acute urinary retention and the incarcerated, retroverted, gravid uterus: a case report. J Reprod Med. 1995;40(6):487–90.

    CAS  PubMed  Google Scholar 

  20. Jena M, Mitch WE. Rapidly reversible acute renal failure from ureteral obstruction in pregnancy. Am J Kidney Dis. 1996;28(3):457–60.

    Article  CAS  Google Scholar 

  21. Wei Q, Zhang L, Liu X. Clinical diagnosis and treatment of acute fatty liver of pregnancy: a literature review and 11 new cases. J Obstet Gynaecol Res. 2010;36:751–6.

    Article  Google Scholar 

  22. Prakash J. The kidney in pregnancy: a journey of three decades. Indian J Nephrol. 2012;22(3):159–67. https://doi.org/10.4103/0971-4065.98750.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. Sibai BM. Imitators of severe pre-eclampsia/eclampsia. Manag High-Risk Pregnancy. 2004;31(4):835–52.

    Google Scholar 

  24. Knight M, Nelson-Piercy C, Kurinczuk JJ, et al. A prospective national study of acute fatty liver of pregnancy in the UK. Gut. 2008;57(7):951–6.

    Article  CAS  Google Scholar 

  25. Colombo DF. Renal disease in pregnancy. In: Obstetrics: Normal and problem pregnancies. Philadelphia: Elsevier/Saunders; 2012. p. 850–61.

    Google Scholar 

  26. Nwoko R, Plecas D, Garovic VD. Acute kidney injury in the pregnant patient. Clin Nephrol. 2012;78(12):478–86.

    Article  Google Scholar 

  27. Nelson MS. Acute urinary retention secondary to an increased gravid uterus. Am J Emerg Med. 1986;4(3):231–2.

    Article  CAS  Google Scholar 

  28. Gary CF. Renal and urinary tract disorders. In: Williams obstetrics. 24th ed. New York: McGraw-Hill Education; 2014. p. 1051–68.

    Google Scholar 

  29. ACOG Committee Opinion No. 475: antenatal corticosteroid therapy for fetal maturation. Obstet Gynecol. 2011;117(2 Pt 1):422–4.

    Google Scholar 

  30. Müller-Deile J, Schiffer M. Preeclampsia from a renal point of view: insides into disease models, biomarkers and therapy. World J Nephrol. 2014;3:169–81.

    Article  Google Scholar 

  31. Galvagno SM, Camann W. Sepsis and acute renal failure in pregnancy. Anesth Analg. 2009;108:572–5.

    Article  Google Scholar 

  32. Wegrzyniak LJ, Repke JT, Ural SH. Treatment of hyperemesis gravidarum. Rev Obstet Gynecol. 2012;5:78–84.

    PubMed  PubMed Central  Google Scholar 

  33. Machado S, Figueiredo N, Borges A, et al. Acute kidney injury in pregnancy: a clinical challenge. J Nephrol. 2012;25:19–30.

    Article  Google Scholar 

  34. Ganesan C, Maynard SE. Acute kidney injury in pregnancy: the thrombotic microangiopathies. J Nephrol. 2011;24:554–63.

    Article  Google Scholar 

  35. Smith JM, Lowe RF, Fullerton J, et al. An integrative review of the side effects related to the use of magnesium sulfate for pre-eclampsia and eclampsia management. BMC Pregnancy Childbirth. 2013;13:34.

    Article  Google Scholar 

  36. KDIGO clinical practice guideline for acute kidney injury. Kidney Int. 2012;2(Suppl.):1–138.

    Google Scholar 

  37. Krane N. Peritoneal dialysis and hemodialysis in pregnancy. Hemodial Int. 2001;5:97–101.

    Article  Google Scholar 

  38. Hladunewich MA, Hou S, Odutayo A, et al. Intensive hemodialysis associates with improved pregnancy outcomes: a Canadian and United States cohort comparison. J Am Soc Nephrol. 2014;25:1103–9.

    Article  CAS  Google Scholar 

  39. Deshpande NA, James NT, Kucirka LM, et al. Pregnancy outcomes in kidney transplant recipients: a systematic review and meta-analysis. Am J Transplant. 2011;11(11):2388–404.

    Article  CAS  Google Scholar 

  40. Kidney Disease: Improving Global Outcomes Transplant Work Group. KDIGO clinical practice guideline for the care of kidney transplant recipients. Am J Transplant. 2009;9(suppl 3):S1–55.

    Google Scholar 

  41. Zheng S, Easterling TR, Umans JG, et al. Pharmacokinetics of tacrolimus during pregnancy. Ther Drug Monit. 2012;34(6):660–70.

    Article  CAS  Google Scholar 

  42. Garg AX, Nevis IF, McArthur E, et al. Gestational hypertension and preeclampsia in living kidney donors. N Engl J Med. 2015;372:124–33.

    Article  CAS  Google Scholar 

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Taha, A.R. (2021). Acute Kidney Injury During Pregnancy. In: Montufar, C., Hidalgo, J., Gei, A.F. (eds) Obstetric Catastrophes. Springer, Cham. https://doi.org/10.1007/978-3-030-70034-8_43

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  • DOI: https://doi.org/10.1007/978-3-030-70034-8_43

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