Abstract
Mycotoxins are secondary metabolites produced by moulds, mostly belonging to the three genera Aspergillus, Penicillium and Fusarium, to survive against environmental stress and attack. Mycotoxin-caused illnesses have been reported worldwide. This chapter covers the classification, transmission and mechanism of action of mycotoxins and their consequences on livestock. There is detail given for various mycotoxins and their causes of infection, transmission and prevention in pig, poultry and cattle farms. Based on studies of animal models and human epidemiological data, it is evident that mycotoxins impose health and economical hazards to human beings and their livestock. Aspergillus, Fusarium and Penicillium are major producers of these mycotoxins in all livestock. These fungi produce mycotoxins in a specific way and toxic effects in immunologically weaker organisms. Mycotoxins may be responsible for cancer, protein calorie malnutrition, weak immunity, skin problem and other metabolic problems. The observation of symptoms of acute mycotoxin poisoning through different causes is simple to characterize, but their role in cancer and other chronic conditions is yet to be proved. A review of literature clearly elucidated that mould contamination is quite different from mycotoxicoses. Besides, mere detection of mycotoxins is not sufficient enough to consider these as aetiological agents in a given veterinary or human health problem. Also, incidence of mycotoxicoses could be higher than proposed. This chapter suggests proper storage and maintaining hygienic conditions of livestock are efficient ways to protect animals from toxicity. The prevention of mycotoxins has been regulated by legal decisions and laws too. Prevention is only option at present due to lack of appropriate detection method and diagnostic test for presence of mycotoxins in food and animals.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Abdel-Wahhab MA, Kholif AM (2008) Mycotoxins in animal feeds and prevention strategies: a review. Asian J Anim Sci 2(1):7–25
Anfossi L, Giovannoli C, Baggiani C (2016) Mycotoxin detection. Curr Opin Biotech 37:120–126
APRES Meeting Report at Savannah, Georgia, from July 21–24 (1981) Proceedings American Peanut Research Education Society Inc 13(1):1–182
Bennett JW, Klich M (2003) Mycotoxins. Clin Microbiol Rev 16(3):497–516
Binder EM (2007) Managing the risk of mycotoxins in modern feed production. Anim Feed Sci Tech 133:149–166
Bottalico A, Perrone G (2002) Toxigenic Fusarium species and mycotoxins associated with head blight in small-grain cereals in Europe. Eur J Plant Pathol 108:611–624
Christensen JJ (1963) Corn smut induced by Ustilago maydis. Amer Phytopathol Soc Monogr 2: pp. 41 pp. ref. 367
Christensen CM, Nelson GH, Mirocha CJ (1965) Effect on the white rat uterus of a toxic substance isolated from Fusarium. Appl Microbiol 13(5):653–659
Dvorska JE, Pappas AC, Karadas F, Speake BK, Surai PF (2007) Protective effect of modified glucomannans and organic selenium against antioxidant depletion in the chicken liver due to T-2 toxin-contaminated feed consumption. Comp Biochem Physiol C Toxicol Pharmacol 145:582–587
Filazi A, Yurdakok B, Yurdakok B, Kuzukiran Ö, Kuzukiran Ö, Tansel U, Ufuk Ş, Şireli T (2017) Mycotoxins in poultry. In: Manafi M (ed) Poultry science. InTech, Rijeka, Croatia, pp 73–92
Foster BC, Trenholm HL, Friend DW, Thompson BK, Hartin KE (1986) Evaluation of different sources of deoxynivalenol (vomitoxin) fed to swine. Can J Anim Sci 66:1149–1154
Galvano F, Piva A, Ritieni A, Galvano G (2001) Dietary strategies to counteract the effects of mycotoxins: a review. J Food Prot 64:120–131
Glahn RP, Wideman RF, Evangelisti JW, Huff WE (1988) Effects of ochratoxin A in combination with citrinin on kidney function of Single Comb White Leghorn pullets. Poult Sci 67:1034–1042
Glahn RP, Sharpiro RS, Vena VE, Wideman RF, Huff WE (1989) Effects of chronic ochratoxin A and citrinin toxicosis on kidney function of Single Comb White Leghorn pullets. Poult Sci 68:1205–1212
Goncalves BL, Corassin CH, Oliveira CAF (2015) Mycotoxicoses in dairy cattle: a review. Asian J Anim Vet Adv 10:752–760
Ha TH (2015) Recent advances for the detection of ochratoxin A. Toxins (Basel) 7(12):5276–5300
Hesseltine CW (1976) Conditions leading to mycotoxin contamination of foods and feeds. In: Rodricks JV (ed) Mycotoxins and other fungal related food problems, Advances in chemistry series, vol 149. American Chemical Society, Washington, DC, pp 1–22
Huff WE, Wyatt RD, Hamilton PB (1975) Nephrotoxicity of dietary ochratoxin A in broiler chickens. Appl Environ Microbiol 30:48–51
Kanora A, Maes D (2009) The role of mycotoxins in pig reproduction: a review. Vet Med-Czech 54(12):565–576
Kegl T, Vanyi A (1991) T-2 fusariotoxicosis in a cattle stock. Mag Allatorvosok 46:467–471
Ledoux DR, Brown TP, Weibking TS, Rottinghaus GE (1992) Fumonisin toxicity in broiler chicks. J Vet Diagn Investig 4:330–333
Liew W-P-P, Mohd-Redzwan S (2018) Mycotoxin: its impact on gut health and microbiota. Front Cell Infect Microbiol 8:Article60:1–17
Mann DD, Buening GM, Hook B, Osweiler GD (1983) Effects of T-2 mycotoxin on bovine serum proteins. Am J Vet Res 44:1757–1759
Marasas WF (1995) Fumonisins: their implications for human and animal health. Nat Toxins 3(4):193–221. https://doi.org/10.1002/nt.2620030405
Murugesan GR, Ledoux DR, Naehrer K, Berthiller F, Applegate TJ, Grenier B, Phillips TD, Schatzmayr G (2015) Prevalence and effects of mycotoxins on poultry health and performance, and recent development in mycotoxin counteracting strategies. Poult Sci 94(6):1298–1315
Ogunade IM, Martinez-Tuppia C, Queiroz OCM, Jiang Y, Drouin P, Wu F, Vyas D, Adesogan AT (2018) Silage review: mycotoxins in silage: occurrence, effects, prevention, and mitigation. J Dairy Sci 101(5):4034–4059
Pestka JJ, Casale WL (1990) Naturally occurring fungal toxins. In: Hriaga S (ed) Food contamination from environmental sources. Wiley, New York, pp 613–638
Pettersson H (2012) Mycotoxin contamination of animal feed. In: Animal feed contamination effects on livestock and food safety, Woodhead publishing series in food science, technology and nutrition. Woodhead Publishing, Oxford, pp 233–285
Pitt JI (2013) Mycotoxins. In: Morris JG Jr, Morris P IV (eds) Foodborne infections and intoxications. Academic Press, Elsevier, New York, pp. 568
Rai M, Varma A (2010) Mycotoxins in food, feed and bioweapons. Springer-Verlag, Berlin Heidelberg, pp. 405
Raiola A, Tenore GC, Manyes L, Meca G, Ritieni A (2015) Risk analysis of main mycotoxins occurring in food for children: an overview. Food Chem Toxicol 84:169–180
Reddy L, Bhoola K (2010) Ochratoxins-food contaminants: impact on human health. Toxins 10(2):771–779
Sanders TH, Davis ND, Diener UL (1968) Effect of carbon dioxide, temperature, and relative humidity on production of aflatoxin in peanuts. J Am Oil Chemists' Soc 45(10):683–685
Scussel VM, Giordano BN, Simao V, Manfio D, Galvao S, Rodrigues MNF (2011) Effect of oxygen-reducing atmospheres on the safety of packaged shelled Brazil nuts during storage. Int J Anal Chem 2011, Article ID 813591, 9 pages
Smith LE, Stoltzfus RJ, Prendergast A (2012) Food chain mycotoxin exposure, gut health, and impaired growth: a conceptual framework. Advances in nutrition (Bethesda, Md.) 3(4):526–531
Sorenson WG, Hesseltine CW, Shotwell OL (1967) Effect of temperature on production of aflatoxin on rice by Aspergillus flavus. Mycopathol Mycol Appl 33:49–55
Speight N (2012) Mycotoxin-related illness. In: Kohlstadt I (ed) Advancing medicine with food and nutrients, 2nd edn. CRC Press; Taylor & Francis Group, Boca Raton, FL, pp 821–850
Steele JΑ, Davis ND, Diener UL (1973) Effect of zinc, copper, and Iron on ochratoxin A production. Appl Environ Microbiol 25:847–849
Streit E, Schwab C, Sulyok M, Naehrer K, Krska R, Schatzmayr G (2013) Multimycotoxin screening reveals the occurrence of 139 different secondary metabolites in feed and feed ingredients. Toxins (Basel) 5:504–523
Talcott PA (2013) Mycotoxins. In: Peterson ME, Talcott PA (eds) Small animal toxicology, 3rd edn. Elsevier, St. Louis, pp 677–682
Taniwaki MH, Hocking AD, Pitt JI, Fleet GH (2010) Growth and mycotoxin production by fungi in atmospheres containing 80% carbon dioxide and 20% oxygen. Int J Food Microbiol 143(3):218–225
Ueno Y, Sawano M, Ishii K (1975) Production of trichothecene mycotoxins by Fusarium species in shake culture. Appl Microbiol 30:4–9
Urry WH (1966) The structure of zearalenone. Tetrahedron Lett 7(27):3109–3114
Urusov AE, Zherdev AV, Petrakova AV, Sadykhov EG, Koroleva OV, Dzantiev BB (2015) Rapid multiple immunoenzyme assay of mycotoxins. Toxins (Basel) 7:238–254
van Egmond HP, Schothorst RC, Jonker MA (2007) Regulations relating to mycotoxins in food: perspectives in a global and European context. Anal Bioanal Chem 389(1):147–157
Wacoo AP, Wendiro D, Vuzi PC, Hawumba JF (2014) Methods for detection of aflatoxins in agricultural food crops. J Appl Chem 2014, Article ID 706291, 15 pages
Weaver GA, Kurtz HJ, Mirocha CJ, Bates FY, Behrens JC, Robison TS, Swanson SP (1980) The failure of purified T-2 mycotoxin to produce hemorrhaging in dairy cattle. Can Vet J 21:210–213
Weibking TS, Ledoux DR, Bermudez AJ, Rottinghaus GE (1993) Effects of fumonisin Blr present in Fusarium moniliforme culture material, in Turkey poults. Poult Sci 72(Suppl. 1):197–199
Wen J, Mu P, Deng Y (2016) Mycotoxins: cytotoxicity and biotransformation in animal cells. Toxicol Res (Camb) 5:377–387
Whitlow, LW, Hagler WM Jr (2005). Mycotoxins in dairy cattle: occurrence, toxicity, prevention and treatment. In: Proceeding of Southwest Nutrition Conference, pp 124–138
Wu F, Groopman JD, Pestka JJ (2014) Public health impacts of foodborne mycotoxins. Annu Rev Food Sci Technol 5:351–372
Yazar S, Omurtag GZ (2008) Fumonisins, trichothecenes and zearalenone in cereals. Int J Mol Sci 9:2062–2090
Web Link Reference
Acknowledgement
Authors are thankful to Dr. Rohan D’souza for due help in preparing this manuscript.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2021 Springer Nature Switzerland AG
About this chapter
Cite this chapter
Anthony, J.M., Asthana, M., Kumar, A. (2021). Mycotoxins and Their Consequences in Livestock. In: Gupta, A., Pratap Singh, N. (eds) Fungal Diseases in Animals. Fungal Biology. Springer, Cham. https://doi.org/10.1007/978-3-030-69507-1_2
Download citation
DOI: https://doi.org/10.1007/978-3-030-69507-1_2
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-69506-4
Online ISBN: 978-3-030-69507-1
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)