Abstract
Monoclonal antibodies (MABs) have proven their efficacy in treating a number of disorders, including multiple sclerosis and leukaemia. However, their use brings a certain perturbation to the immune system, increasing the risk of disorders which arise in immunosuppressed environment, such as activation of the latent John Cunningham (JC) virus causing PML (progressive multifocal leukoencephalopathy) described in this case. PML is a rare but debilitating and often fatal demyelinating disease. All patients treated with MABs should be monitored for CNS symptoms and thoroughly examined for PML if they occur.
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Vavro, H. (2021). Progressive Multifocal Leukoencephalopathy (PML) After Obinutuzumab Treatment for Chronic Lymphocytic Leukaemia (CLL). In: Neuroradiology - Images vs Symptoms. Springer, Cham. https://doi.org/10.1007/978-3-030-69213-1_24
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DOI: https://doi.org/10.1007/978-3-030-69213-1_24
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