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Protein Visualization in Leukemia Cells

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Epigenetics and Proteomics of Leukemia

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Abstract

Alterations in histone modifications have been linked to deregulation of many genes expression important for cancer development and unregulated cancer progression. Therefore, epigenetic modifiers used in cancer therapy have an impact to remodel chromatin with replacement of histone modifications and thus restore the normal state of cells. In Chap. 8 we demonstrated the comparative analysis of histones, their variants and modifications during granulocytic differentiation of leukemic cells. By using computational methods for protein localization estimation the changes in modifications of histones H3 and H4 and other proteins important for leukemia cell differentiation were determined.

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Authors and Affiliations

  1. Department of Molecular Cell Biology Institute of Biochemistry Life Sciences Center, Vilnius University, Vilnius, Lithuania

    Rūta Navakauskienė & Veronika Borutinskaitė

  2. Department of Electronic Systems Faculty of Electronics, Vilnius Gediminas Technical University, Vilnius, Lithuania

    Dalius Navakauskas & Dalius Matuzevičius

Authors
  1. Rūta Navakauskienė
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  2. Dalius Navakauskas
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  3. Veronika Borutinskaitė
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  4. Dalius Matuzevičius
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Navakauskienė, R., Navakauskas, D., Borutinskaitė, V., Matuzevičius, D. (2021). Protein Visualization in Leukemia Cells. In: Epigenetics and Proteomics of Leukemia. Springer, Cham. https://doi.org/10.1007/978-3-030-68708-3_8

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