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Protein Phosphorylation in Leukemia

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Epigenetics and Proteomics of Leukemia

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Abstract

Despite the growing volume of studies demonstrating the importance of post-translational modifications modulating protein functions we still need to reveal its impact to normal and pathogenic cell development. Protein tyrosine phosphorylation is the protein modification that plays an essential role in cellular signaling and function regulation. In Chap. 5 we present our studies designed to protein tyrosine phosphorylation impact in the pathogenesis of AML and its possible role linked to normal cell proliferation, differentiation and apoptosis. The results of the studies presented here demonstrate the changes and distribution of tyrosine phosphorylated proteins in the cytoplasm and the nucleus during differentiation of leukemic cells. Identified newly tyrosine phosphorylated proteins in differentiating leukemia cells could be important due to their role for normal cellular functions and also due to their drug-targeting potential for leukemia treatment.

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Authors and Affiliations

  1. Department of Molecular Cell Biology Institute of Biochemistry Life Sciences Center, Vilnius University, Vilnius, Lithuania

    Rūta Navakauskienė & Veronika Borutinskaitė

  2. Department of Electronic Systems Faculty of Electronics, Vilnius Gediminas Technical University, Vilnius, Lithuania

    Dalius Navakauskas & Dalius Matuzevičius

Authors
  1. Rūta Navakauskienė
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  2. Dalius Navakauskas
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  3. Veronika Borutinskaitė
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  4. Dalius Matuzevičius
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Navakauskienė, R., Navakauskas, D., Borutinskaitė, V., Matuzevičius, D. (2021). Protein Phosphorylation in Leukemia. In: Epigenetics and Proteomics of Leukemia. Springer, Cham. https://doi.org/10.1007/978-3-030-68708-3_5

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