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Diseases of the Fallopian Tube

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Practical Gynecologic Pathology

Part of the book series: Practical Anatomic Pathology ((PAP))

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Abstract

The fallopian tube, a small organ named after the Italian anatomist Gabriele Falloppio, has recently risen to center stage in the field of gynecologic pathology. This chapter provides a good discussion of commonly encountered entities in daily practice, including non-neoplastic lesions, precancerous lesions, and fallopian tube neoplasms. A wide variety of benign lesions including those related to infertility and ectopic pregnancy are discussed. Of these, acute and chronic inflammation of the fallopian tube and related complications play a key role. Pseudocarcinomatous hyperplasia can particularly pose diagnostic difficulty. Pregnancy-related tubal manifestations including the likelihood of overdiagnosis of hydatidiform mole are briefly noted. The spectrum of entities that include p53 signature, secretory cell outgrowth (SCOUT), serous tubal intraepithelial lesions (STIL), and serous tubal intraepithelial carcinoma (STIC) are emphasized and widely discussed; these concepts are at the forefront of our understanding of the initiation and development of extrauterine serous carcinoma. As a common primary fallopian tube carcinoma, high-grade serous carcinoma and endometrioid carcinoma are also discussed. Miscellaneous tumors commonly encountered in the paratubal regions are discussed and include mesothelial tumors (adenomatoid tumor, well-differentiated papillary mesothelioma, and peritoneal malignant mesothelioma) and the female adnexal tumor of probable Wolffian origin (FATWO). The final sections cover metastatic carcinomas to the fallopian tube from gynecologic and nongynecologic origins.

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Abbreviations

AGCT:

Adult granulosa cell tumor

CD10:

Cluster designation or cluster of differentiation 10; also known as CALLA (common acute lymphocytic leukemia antigen)

CIC:

cortical inclusion cysts

CK 7:

Cytokeratin 7

CK20:

Cytokeratin 20

CMV:

Cytomegalovirus

DPAM:

Disseminated peritoneal adenomucinosis

EMA:

Epithelial membrane antigen

ER:

Estrogen receptor

FATWO:

Female adnexal tumors of probable Wolffian origin

GATA3 :

GATA Binding Protein 3

GCDFP-15:

Gross cystic disease fluid protein 15

GIST:

gastrointestinal stromal tumors

HBME-1:

Hector Battifora mesothelial-1

hCG:

Human chorionic gonadotropin

HGSC:

high-grade serous carcinoma

IUD:

intrauterine device

LGSC:

low-grade serous carcinoma

MM:

malignant mesothelioma

NOS:

Not Otherwise Specified

OSE:

ovarian surface epithelium

PAX2:

Paired box gene 2

PAX8:

Paired box gene 8

PEComas:

perivascular epithelioid cell neoplasms

PR:

Progesterone receptor

PSN:

placental site nodule

PTH:

papillary tubal hyperplasia

SBT/APST:

Serous borderline tumor/atypical proliferative serous tumor

SCOUT:

secretory cell outgrowth

SCT:

Sertoli cell tumor (SCT)

SEE-FIM:

sectioning and extensively examining the fimbriated end of the fallopian tubes

SF-1:

Steroidogenic factor-1

SIN:

Salpingitis isthmica nodosa

SLCT:

Sertoli-Leydig cell tumors

STIC:

serous tubal intraepithelial carcinoma

STIL:

serous tubal intraepithelial lesions

WDPM:

Well differentiated papillary mesothelioma

WHO:

World Health Organization

WT-1:

Wilms tumor protein 1

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Author information

Authors and Affiliations

  1. Department of Pathology, Division of Gynecologic Pathology, Johns Hopkins Medical Institutions, Baltimore, MD, USA

    Deyin Xing

  2. Department of Pathology, Oregon Health & Science University School of Medicine, Portland, OR, USA

    Olivia L. Snir

  3. Department of Pathology, Yale School of Medicine, New Haven, CT, USA

    Pei Hui

Authors
  1. Deyin Xing
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  2. Olivia L. Snir
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  3. Pei Hui
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Correspondence to Deyin Xing .

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Editors and Affiliations

  1. Department of Pathology, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA

    Jian-Jun Wei

  2. Department of Pathology, Yale School of Medicine, New Haven, CT, USA

    Pei Hui

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Xing, D., Snir, O.L., Hui, P. (2021). Diseases of the Fallopian Tube. In: Wei, JJ., Hui, P. (eds) Practical Gynecologic Pathology. Practical Anatomic Pathology. Springer, Cham. https://doi.org/10.1007/978-3-030-68608-6_8

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