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Uterine Epithelial Neoplasia

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Practical Gynecologic Pathology

Part of the book series: Practical Anatomic Pathology ((PAP))

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Abstract

Nonneoplastic lesions of the endometrium encompass a broad spectrum of epithelial alternations ranging from metaplasia, hormonal related changes, inflammatory processes, reparative conditions, endometrial polyps, and gestational alterations. Many of these conditions can mimic various malignant or premalignancy lesions of the endometrium, particularly when present in a small biopsy or curettage specimen. Endometrial hyperplasia and atypical hyperplasia are preneoplastic conditions that precede the most common endometrioid adenocarcinoma. Serous and clear cell carcinomas are high-grade carcinomas by definition and account for about 10–15% of endometrial malignancy. Other histological types are rare, including high neuroendocrine carcinomas, undifferentiated carcinomas, dedifferentiated carcinoma, and mixed carcinomas. Molecular classification of endometrial cancers may provide added diagnostic and prognostic information.

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Abbreviations

CHEC:

Endometrioid adenocarcinoma with cords and hyalinized stroma

EIN:

Endometrial intraepithelial neoplasia

HPV:

Human papillomavirus

LCNEC:

Large cell neuroendocrine carcinoma

MELF:

Microcystic, elongated, and fragmented invasion

MMR:

DNA mismatch repair

MSI:

Microsatellite instability

POLE:

DNA polymerase epsilon

SCNEC:

Small cell neuroendocrine carcinoma

TCGA:

The Cancer Genome Atlas program

WHO:

World Health Organization

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Author information

Authors and Affiliations

  1. Department of Pathology, Yale School of Medicine, New Haven, CT, USA

    Pei Hui

  2. University of Wisconsin, Madison, WI, USA

    Christopher Flynn

  3. The Warren Alpert Medical School of Brown University, Women and Infants Hospital, Division of Gynecologic and Breast Pathology, Providence, RI, USA

    M. Ruhul Quddus

Authors
  1. Pei Hui
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  2. Christopher Flynn
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  3. M. Ruhul Quddus
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Corresponding author

Correspondence to Pei Hui .

Editor information

Editors and Affiliations

  1. Department of Pathology, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA

    Jian-Jun Wei

  2. Department of Pathology, Yale School of Medicine, New Haven, CT, USA

    Pei Hui

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Hui, P., Flynn, C., Quddus, M.R. (2021). Uterine Epithelial Neoplasia. In: Wei, JJ., Hui, P. (eds) Practical Gynecologic Pathology. Practical Anatomic Pathology. Springer, Cham. https://doi.org/10.1007/978-3-030-68608-6_5

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  • DOI: https://doi.org/10.1007/978-3-030-68608-6_5

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  • Online ISBN: 978-3-030-68608-6

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