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Non-HPV-Associated Cervical Neoplasia

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Practical Gynecologic Pathology

Part of the book series: Practical Anatomic Pathology ((PAP))

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Abstract

Although overwhelming majority of uterine cervical carcinomas are high-risk human papilloma virus (hrHPV)-associated tumors, growing body of literature suggests the existence of a significant percentage of non-HPV cervical adenocarcinomas. This has led to the recent proposal of categorizing cervical adenocarcinomas into hrHPV-associated and hrHPV-nonassociated tumors. Rare examples of non-HPV-associated squamous cell carcinoma are also available in the literature, although that is not the norm. In addition, one should always remember the possibility of metastatic tumors, gestational trophoblastic tumors, and the great mimicker malignant melanoma while evaluating cervical biopsies/resections. Some benign lesions of the cervix can also create diagnostic challenges for practicing pathologists as these are not too frequently encountered in daily practice. This chapter attempts to address some of the questions and scenarios that a practicing pathologist may face in their daily practice.

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Abbreviations

ASC-h:

Atypical squamous cells cannot rule out high-grade dysplasia

CEA:

Carcinoembryonic antigen

ETT:

Epithelioid trophoblastic tumors

GATA:

G-A-T-A nucleotide sequence

hCG:

Human chorionic gonagotropin

hrHPV:

High-risk human papilloma virus

MDA:

Minimally deviated adenocarcinoma

MGH:

Microglandular hyperplasia

MM:

Malignant melanoma

NOS:

Not otherwise specified

PEComa:

Perivascular epithelioid tumor

PNET:

Peripheral neuroectodermal tumor

PSN:

Placental site nodule

SCTAT:

Sex cord stromal tumor with annular tubules

TTF-1:

Thyroid transcription factor 1

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Author information

Authors and Affiliations

  1. The Warren Alpert Medical School of Brown University, Women and Infants Hospital, Division of Gynecologic and Breast Pathology, Providence, RI, USA

    M. Ruhul Quddus

  2. Department of Pathology & Laboratory Medicine, The Warren Alpert Medical School of Brown University, Providence, RI, USA

    Joyce J. Ou

  3. Department of Pathology, Yale School of Medicine, New Haven, CT, USA

    Pei Hui

Authors
  1. M. Ruhul Quddus
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  2. Joyce J. Ou
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  3. Pei Hui
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Correspondence to M. Ruhul Quddus .

Editor information

Editors and Affiliations

  1. Department of Pathology, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA

    Jian-Jun Wei

  2. Department of Pathology, Yale School of Medicine, New Haven, CT, USA

    Pei Hui

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Quddus, M.R., Ou, J.J., Hui, P. (2021). Non-HPV-Associated Cervical Neoplasia. In: Wei, JJ., Hui, P. (eds) Practical Gynecologic Pathology. Practical Anatomic Pathology. Springer, Cham. https://doi.org/10.1007/978-3-030-68608-6_4

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  • DOI: https://doi.org/10.1007/978-3-030-68608-6_4

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